Abstract:
:Several 5-alkoxy-tetrazolo[1,5-a]quinazoline derivatives have been synthesized by reacting 2,4-dichloroquinazoline with various phenols or aliphatic alcohol and then with sodium azide. The structures of these compounds have been confirmed by IR, MS,( 1)H-NMR, and elementary analysis. Anticonvulsant activities were evaluated using the maximal electroshock (MES) test. Most of the synthesized compounds displayed weak anticonvulsant activity at a dose of 300 mg/kg. Antidepressant activities were investigated by forced swimming test. Two compounds, namely 5-(hexyloxy)tetrazolo[1,5-a]quinazoline and 5-(4-methoxyphenoxy)tetrazolo[1,5-a]quinazoline, showed significant antidepressant activity, which decreased the immobility time by 62.2 and 51.7% at 100 mg/kg dose level.
journal_name
Arch Pharm (Weinheim)journal_title
Archiv der Pharmazieauthors
Wang HJ,Wei CX,Deng XQ,Li FL,Quan ZSdoi
10.1002/ardp.200900119subject
Has Abstractpub_date
2009-11-01 00:00:00pages
671-5issue
11eissn
0365-6233issn
1521-4184journal_volume
342pub_type
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