Abstract:
:Three novel series of quinoline derivatives have been prepared by cyclization of the intermediate 3-(1,3-dioxolan-2-yl)-2-substituted thiocarbamoyl-hydrazinoquinolines with different alpha-halocarbonyl compounds. These series are: 3-(1,3-dioxolan-2-yl)-2-(3-substituted-4-phenylthiazolin-2-y lidene) hydrazinoquinolines; 3-(1,3-dioxolan-2-yl)-2-(3-substituted-5-ethoxycarbonyl- 4-methylthiazoline-2-ylidene)hydrazinoquinolines and 3-(1,3-dioxolan-2-yl)-2- (3-substituted-4-thiazolidinon-2-yl)hydrazinoquinolines. The active methylene group of the latter series was used for the preparation of their arylidene derivatives. The antimicrobial as well as inotropic and chronotropic activities of the prepared compounds were studied.
journal_name
Arch Pharm (Weinheim)journal_title
Archiv der Pharmazieauthors
Farghaly AM,Habib NS,Khalil MA,el-Sayed OA,Bistawroos AEdoi
10.1002/ardp.19903230414subject
Has Abstractpub_date
1990-04-01 00:00:00pages
247-51issue
4eissn
0365-6233issn
1521-4184journal_volume
323pub_type
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