Abstract:
:Fifteen new indazole derivatives have been synthesized. In the Born test, compounds (4f) and (4g) were most active. They inhibited the blood platelet aggregation induced by collagen with an IC(50) = 85 or 90 microM, respectively. After oral administration to rats (60 mg/kg) three of the compounds significantly inhibited the formation of thrombi in arterioles and venules. The strongest effect was observed with (4j) which showed an inhibition of 15% in arterioles and 7% in venules. Further experiments showed that compound (4j) does not mediate these effects by activating soluble guanylate cyclase, but likely by inhibiting phosphodiesterase isoform PDE 5.
journal_name
Arch Pharm (Weinheim)journal_title
Archiv der Pharmazieauthors
Yildiz AK,Rehse K,Stasch JP,Bischoff Edoi
10.1002/ardp.200300832keywords:
subject
Has Abstractpub_date
2004-06-01 00:00:00pages
311-6issue
6eissn
0365-6233issn
1521-4184journal_volume
337pub_type
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