Abstract:
:A number of phenylamides of 5-benzamidopyrazole-4-carboxylic acid were prepared in 50-80% yields from 1-phenyl (or methyl)-6-phenylpyrazolo[3,4-d]1,3-oxazin-4(1H)-ones and aniline derivatives. All the compounds were tested for their analgesic and antiinflammatory activities, as well as for their ulcerogenic potential and acute toxicity. Some derivatives, when compared to phenylbutazone, proved more active in the tests for analgesic and antiexudative activities, but less active in the carrageenin paw oedema test. The compounds proved to posses marginal or no ulcerogenic effect, as well as low systemic toxicity.
journal_name
Arch Pharm (Weinheim)journal_title
Archiv der Pharmazieauthors
Daidone G,Plescia F,Maggio B,Raffa D,Cutuli VM,Mangano NG,Caruso Adoi
10.1002/1521-4184(200105)334:5<153::aid-ardp153>3.keywords:
subject
Has Abstractpub_date
2001-05-01 00:00:00pages
153-6issue
5eissn
0365-6233issn
1521-4184pii
10.1002/1521-4184(200105)334:5<153::AID-ARDP153>3.journal_volume
334pub_type
杂志文章abstract::A new class of acetamidomethylsulfonyl bis heterocycles-oxazolyl-1,3,4-oxadiazoles, -thiazolyl-1,3,4-oxadiazoles, and -imidazolyl-1,3,4-oxadiazoles were synthesized from the synthetic intermediates, methyl 2-((4-aryloxazol-2-ylcarbamoyl)methylsulfonyl)acetate, methyl 2-((4-arylthiazol-2-ylcarbamoyl)methylsulfonyl)acet...
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pub_type: 杂志文章
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