Abstract:
:The 5-HT1A and 5-HT2 receptor affinity of a set of 44 N-alkylated 1-aryl-piperazines and their analogs has been analyzed: the n-hexyl derivatives were the most potent and the most selective 5-HT1A ligands of all the investigated N-alkyl homologues. The alkyl chain may stabilize the 5-HT1A receptor-ligand complex by hydrophobic forces. A set of the alkyl substituent contributions (CHT1A) for prediction of the 5-HT1A affinity of N-alkyl derivatives of 1-arylpiperazines and related compounds have been defined on the basis of the Free-Wilson analysis.
journal_name
Arch Pharm (Weinheim)journal_title
Archiv der Pharmazieauthors
Mokrosz JL,Mokrosz MJ,Charakchieva-Minol S,Paluchowska MH,Bojarski AJ,Duszyńska Bdoi
10.1002/ardp.19953280210subject
Has Abstractpub_date
1995-02-01 00:00:00pages
143-8issue
2eissn
0365-6233issn
1521-4184journal_volume
328pub_type
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