Abstract:
:New series of perimidine derivatives and fused perimidines were derived from the reaction of ketene aminals 1 and 2 with diazotized anilines or hydrazonoyl chlorides. In addition, 8,10-disubstituted-[1,2,4]triazolo[4,3-a]perimidines (20a-m) were prepared through the reaction of perimidine-2-thione (15) with hydrazonoyl chlorides. The structures of the newly synthesized compounds were established on the basis of spectral data and elemental analyses. Some products were investigated for their antitumor activities against the human breast cancer cell line MCF-7 and the liver carcinoma cell line HEPG-2, and the results of some derivatives showed promising activity.
journal_name
Arch Pharm (Weinheim)journal_title
Archiv der Pharmazieauthors
Farghaly TA,Mahmoud HKdoi
10.1002/ardp.201200486subject
Has Abstractpub_date
2013-05-01 00:00:00pages
392-402issue
5eissn
0365-6233issn
1521-4184journal_volume
346pub_type
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