Abstract:
:N-Methoxyquinolinium salts 3 are prepared as potential cardiotonic agents by alkylation of the corresponding N-oxides 2 synthesized by two different methods. 1. Oxidation of some quinoline derivatives 1 using 30% H2O2 or 3-chloroperbenzoic acid. 2. Nitration of the quinoline-N-oxides 2a, 2c, and 2m. Preparation of 2h and 2k requires subsequent nucleophilic ipso-substitution of the nitro group. The compounds 3 are tested for positive inotropic activity on isolated left atria and papillary muscles from guinea-pig. Structure activity relationships indicate that the effect depends on the N-methoxy group of the target compounds as well as on the presence of an electron-withdrawing substituent.
journal_name
Arch Pharm (Weinheim)journal_title
Archiv der Pharmazieauthors
Bünz C,Heber D,Ravens Udoi
10.1002/ardp.19933260410subject
Has Abstractpub_date
1993-04-01 00:00:00pages
229-36issue
4eissn
0365-6233issn
1521-4184journal_volume
326pub_type
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