Synthesis and antitumour activity of new derivatives of flavone-8-acetic acid (FAA). Part 4: Variation of the basic structure.

Abstract:

:A range of 11 derivatives of flavone-8-acetic acid (FAA) in which the structure has been substantially altered in different ways have been prepared and their anti-tumour activity evaluated in vitro against a panel of human and murine tumour cell lines and in vivo against MAC 15A. The generally poor activity observed shows that the basic structure cannot be altered much without destroying the activity.

journal_name

Arch Pharm (Weinheim)

journal_title

Archiv der Pharmazie

authors

Aitken RA,Bibby MC,Cooper PA,Double JA,Laws AL,Ritchie RB,Wilson DW

doi

10.1002/1521-4184(20006)333:6<181::aid-ardp181>3.0

keywords:

subject

Has Abstract

pub_date

2000-06-01 00:00:00

pages

181-8

issue

6

eissn

0365-6233

issn

1521-4184

pii

10.1002/1521-4184(20006)333:6<181::AID-ARDP181>3.0

journal_volume

333

pub_type

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