Abstract:
:Novel C-5 substituted 6,2'-anhydrouridines 5a-e are synthesized from the hitherto unknown monosubstituted ribofuranosylbarbituric acid derivatives 4a-e. These molecules are high-anti-fixed by a 6,2'-linkage and were assumed to show antiviral and antineoplastic effects. In cell culture test systems, however, none of these biological activities could be detected up to now.
journal_name
Arch Pharm (Weinheim)journal_title
Archiv der Pharmazieauthors
Folkers G,Junginger G,Müller CE,Schloz U,Eger Kdoi
10.1002/ardp.19893220213subject
Has Abstractpub_date
1989-02-01 00:00:00pages
119-23issue
2eissn
0365-6233issn
1521-4184journal_volume
322pub_type
杂志文章abstract::A rapid and efficient one-pot condensation reaction of long-chain alkyl and alkenyl acid hydrazides and nitriles was carried out to afford 3,5-disubstituted-1H-1,2,4-triazoles. The compounds 5a-o were screened for in-vitro antibacterial activity against the representative panel of two Gram-positive and two Gram-negati...
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journal_title:Archiv der Pharmazie
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abstract::The plant pentacyclic alkaloid camptothecin and its structural analogs were extensively studied. These compounds are interesting due to the antitumor activity associated with their ability to inhibit topoisomerase I in tumor cells. During the last decades of the 20th century, a large number of the silicon-containing c...
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abstract::Copper and zinc have been found to contribute to the burden of amyloid-β (Aβ) aggregations in neurodegenerative Alzheimer's disease (AD). Dysregulation of these metals leads to the generation of reactive oxygen species (ROS) and eventually results in oxidative damage and accumulation of the Aβ peptide, which are the k...
journal_title:Archiv der Pharmazie
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journal_title:Archiv der Pharmazie
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更新日期:1998-01-01 00:00:00
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