2")-beta-D-apiofuranosyldiphyllin, named procumbenoside B (2), along with cilinaphthalide B (3) and several" />
Abstract:
:Two new arylnaphthalide lignans, procumphthalide A (1) and 4-O-beta-D-glucopyranosyl-(1"'-->2")-beta-D-apiofuranosyldiphyllin, named procumbenoside B (2), along with cilinaphthalide B (3) and several other known compounds were isolated from the methanolic extracts of Justicia procumbens. By using NMR and other spectral methods, the structures of 1 and 2 were elucidated. Cilinaphthalide B (3), justicidin A (4), and taiwan E methyl ether (5) were shown to have an antiplatelet effect in human plateletrich plasma. In human citrated PRP, 5 showed a strong inhibitory effect on platelet aggregation induced by adrenaline in a concentration-dependent manner, with an IC(50) value of about 27.6 microM.
journal_name
Arch Pharm (Weinheim)journal_title
Archiv der Pharmazieauthors
Weng JR,Ko HH,Yeh TL,Lin HC,Lin CNdoi
10.1002/ardp.200300841keywords:
subject
Has Abstractpub_date
2004-04-01 00:00:00pages
207-12issue
4eissn
0365-6233issn
1521-4184journal_volume
337pub_type
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