Abstract:
:A series of 5-amino-3-methylisoxazole-4-carboxylic acid amides has been prepared by condensation of 5-amino-3-methylisoxazole-4-carboxylic acid with ethyl chloroformate. The resulting mixed anhydride undergoes condensation with appropriate phenylamides to form the corresponding amides 6-16. The compounds obtained were evaluated for their immunological activities in cultures of human peripheral blood mononuclear cells (PMBC). We found that the activities of the compounds in the proliferation test and in the lipopolysaccharide (LPS)-induced cytokine production in PBMC cultures were differential. The stimulatory or inhibitory effects depended strongly on the origin and location of substituents in the phenyl ring which is described in the discussion and was supported by QSAR studies.
journal_name
Arch Pharm (Weinheim)journal_title
Archiv der Pharmazieauthors
Ryng S,Zimecki M,Sonnenberg Z,Mokrosz MJdoi
10.1002/(sici)1521-4184(19995)332:5<158::aid-ardp1keywords:
subject
Has Abstractpub_date
1999-05-01 00:00:00pages
158-62issue
5eissn
0365-6233issn
1521-4184pii
10.1002/(SICI)1521-4184(19995)332:5<158::AID-ARDP1journal_volume
332pub_type
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