A modern approach to the gonadotropin treatment in oligozoospermia.

Abstract:

:A critical review of the gonadotropin therapy in male infertility or hypofertility is presented. In the author's opinion, the poor and conflicting results so far obtained wih this kind of treatment are mainly due to inadequate selection of the patients admitted to the treatment itself. The author stresses some points concerning the modern knowledge on the physiology of gonadotropin secretion in males; points that must be borne in mind in approaching this type of treatment, and which in some way revolutionize the old concept of "low" or "high" plasma gonadotropin levels. In this concern, the gonadotropin therapy can be applied not only to the hypogonadotropic hypogonadism, as for the past, but also to the spermatogenic arrests and to the idiopathic oligospermiogenesis wtih "normal" gonadotropin levels. The author then exposes the rigid criteria adopted in the Andrologic Center of the 5th Medical Clinic of the University of Rome for the selection of the patients to be admitted to the treatment; criteria which are based on hormonal, morphological and seminal parameters. In the final part the results are reported obtained in the selected patients with a treatment schedule with associated HMG + MCG (150--300 I.U. as FSH per week and 2000--6000 I.U. as LH per week for 12--16 weeks). The results seem very encouraging: in 85% of the patients a quantitative and qualitative amelioration of the spermatogenesis was obtained; in 30% of these cases an outcome of pregnancies in the partner has been documented so far.

journal_name

Andrologia

journal_title

Andrologia

authors

Isidori A

doi

10.1111/j.1439-0272.1981.tb00030.x

subject

Has Abstract

pub_date

1981-05-01 00:00:00

pages

187-97

issue

3

eissn

0303-4569

issn

1439-0272

journal_volume

13

pub_type

杂志文章,评审
  • Three cases of low chiasma frequency associated with infertility in man.

    abstract::Three new cases of low chiasma frequency in infertile men are described. In the first case, all cells showed abnormal diakineses; in the second, 20% of the diakineses were desynaptic, while the remaining 80% were normal; in the third, all diakineses were desynaptic and showed chromosome fragmentation. The possible mec...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1976.tb01657.x

    authors: Templado C,Marina S,Egozcue J

    更新日期:1976-01-01 00:00:00

  • Response of the testis to gonadotrophin replacement in young hypophysectomized vs. gonadotrophin-releasing hormone antagonist-treated rats.

    abstract::We have studied the response of atrophic Leydig cells to gonadotrophin replacement in young hypophysectomized (HX) and GnRH antagonist (GnRH-ANT)-treated rats. Hypophysectomy was performed at 28 days of age. Age-matched rats were treated with GnRH-ANT from 28 to 51 days of age. From 45 to 51 days of age, animals were ...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1997.tb00468.x

    authors: Gaytan F,Bellido C,Morales C,Aguilar E

    更新日期:1997-03-01 00:00:00

  • Effect of Lepidium meyenii (MACA) on sexual desire and its absent relationship with serum testosterone levels in adult healthy men.

    abstract::This study was a 12-week double blind placebo-controlled, randomized, parallel trial in which active treatment with different doses of Maca Gelatinizada was compared with placebo. The study aimed to demonstrate if effect of Maca on subjective report of sexual desire was because of effect on mood or serum testosterone ...

    journal_title:Andrologia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1439-0272.2002.00519.x

    authors: Gonzales GF,Córdova A,Vega K,Chung A,Villena A,Góñez C,Castillo S

    更新日期:2002-12-01 00:00:00

  • Robotic-assisted laparoscopic artery-sparing varicocelectomy using indocyanine green fluorescence angiography: Initial experience.

    abstract::We reported our initial experience of robotic-assisted laparoscopic artery-sparing varicocelectomy using indocyanine green (ICG) fluorescence angiography in treatment of varicocele. A total of 45 varicocelectomies in 27 patients were performed. The mean operation time was 49.1 ± 8.5 min for unilateral and 65.6 ± 8.3 m...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13774

    authors: Teng J,Jia Z,Ai X,Luo X,Guan Y,Hao X,Fei W

    更新日期:2020-12-01 00:00:00

  • Testosterone-induced changes in testicular antioxidant system.

    abstract::In order to investigate the role of testosterone propionate (TP) on the antioxidant system of the rat testis, lipid peroxidation (LPX) and activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) of the testis of testosterone-treated and control rats were compared. The results indicate...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1997.tb00328.x

    authors: Chainy GB,Samantaray S,Samanta L

    更新日期:1997-11-01 00:00:00

  • Physiological action of oestradiol on the acrosome reaction in human spermatozoa.

    abstract::The acrosome is a secretory vesicle located in the sperm head. The acrosome reaction consists in the fusion of the sperm plasma membrane with the external acrosomal membrane. It has been observed that this reaction does not take place in spermatozoa incubated in cervical mucus, hydrogel that contains high concentratio...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.2007.00814.x

    authors: Vigil P,Toro A,Godoy A

    更新日期:2008-06-01 00:00:00

  • Effect of chronic chloroquine treatment on prostaglandin and human chorionic gonadotropin (hCG) stimulation of testosterone secretion by the rat testis.

    abstract::The effect of chronic chloroquine administration on prostaglandin E1 (PGE1) and human chorionic gonadotropin (hCG) stimulation of testosterone secretion by the rat Leydig cells was studied. Adult albino (Wistar strain) rats were injected with 4 mg/kg body weight of chloroquine phosphate every other day for 30 days. At...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1987.tb01900.x

    authors: Nduka EU,Dada OA

    更新日期:1987-09-01 00:00:00

  • CAG Repeats in the androgen receptor gene is associated with oligozoospermia and teratozoospermia in infertile men in Jordan.

    abstract::CAG trinucleotide repeats are coded for the polyglutamine tract in the N-terminal of the androgen receptor (AR) gene which varies in normal individuals from 6 to 36 residues. In this study, we inspected the impact of the CAG repeats on the spermatogenic defects by measuring the size of AR-CAG repeats length in a cohor...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13728

    authors: Al Zoubi MS,Bataineh H,Rashed M,Al-Trad B,Aljabali AAA,Al-Zoubi RM,Al Hamad M,Issam AbuAlArjah M,Batiha O,Al-Batayneh KM

    更新日期:2020-10-01 00:00:00

  • Association of IgA secretory component sialylation with leucocytospermia of infertile men - a pilot study.

    abstract::The aim of our pilot study was to check whether the differences in IgA secretory component (SC) sialylation are associated with leucocytospermia. In normozoospermic and leucocytospermic seminal plasmas, 78-kDa and 63-kDa SC immunoreactive bands were observed. The SC sialylation was analysed by lectin blotting, using s...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.12213

    authors: Kratz EM,Ferens-Sieczkowska M

    更新日期:2014-12-01 00:00:00

  • Effect of lycopene on testicular androgenic and anti-oxidative enzymes in cyproterone acetate-induced male infertile Wistar strain albino rats: An in vitro study.

    abstract::Incidents of male infertility are mushrooming worldwide. Oxidative stress plays a prime role for its onset. Considering this background, the study was designed to focus the direct role of lycopene on cyproterone acetate (CPA) induced testicular hypofunction in rat. Four groups have been considered including the vehicl...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13494

    authors: Tripathy A,Ara F,Ghosh P,Ghosh D

    更新日期:2020-04-01 00:00:00

  • HAART and anti-Koch's impair sexual competence, sperm quality and offspring quality when used singly and in combination in male Wistar rats.

    abstract::This study investigated the impact of the administration of HAART and anti-Koch's, singly and in combination, on sexual competence and birth statistics. Adult male Wistar rats were randomised into distilled water-treated control, HAART-treated, anti-Koch's-treated and HAART + anti-Koch's-treated groups. The 56-day ora...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13951

    authors: Akhigbe RE,Hamed MA,Odetayo AF

    更新日期:2021-01-05 00:00:00

  • The synthetic androgen mibolerone induces transient suppression of the transformed phenotype in an androgen responsive human prostatic carcinoma cell line.

    abstract::The synthetic androgen mibolerone elicits a set of distinct changes in the behaviour of an androgen responsive human prostatic carcinoma cell line (LNCaP). Inhibition of cell proliferation, induction of morphological change and of a prostate specific mRNA, and inhibition of colony formation in soft agar are induced by...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1990.tb02071.x

    authors: Schulz P,Wolf D,Arbusow V,Bojar H,Klobeck HG,Fittler F

    更新日期:1990-01-01 00:00:00

  • Berberine inhibits experimental varicocele-induced cell cycle arrest via regulating cyclin D1, cdk4 and p21 proteins expression in rat testicles.

    abstract::The aim of this study was to uncover the protective effect of berberine (BBR), an antioxidant chemical, on experimental varicocele (VCL)-induced adverse effects on cell cycle machinery during early germ cells mitosis. To follow-up this study, 30 mature male Wistar rats were divided into control-sham, nontreated VCL, 5...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.12984

    authors: Amin M,Razi M,Sarrafzadeh-Rezaei F,Shalizar Jalali A,Najafi G

    更新日期:2018-02-14 00:00:00

  • Association between lower urinary tract symptoms and sexual dysfunction in Taiwanese men.

    abstract::The study investigated the association between lower urinary tract symptoms (LUTS) and sexual dysfunction in ageing men. It was a cross-sectional study in an unselected consecutive sample of 398 men aged >40 years attending a urology clinic. LUTS and sexual function were assessed by validated symptom scales, including...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.2008.00876.x

    authors: Tsao CW,Cha TL,Lee SS,Tang SH,Wu ST,Tsui KH,Sun GH

    更新日期:2008-12-01 00:00:00

  • Lack of immunization after intraperitoneal insemination of spermatozoa.

    abstract::Twenty infertile patients with normal tubal patency were inseminated intraperitoneally (11 once, seven twice, and two three times) with spermatozoa (mean 14 x 10(6), range 0.6-48 x 10(6)) prepared by the standard swim-up technique. The occurrence of immunization to spermatozoa was looked for by the Gelatin Agglutinati...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1993.tb02673.x

    authors: Ragni G,Lenzi A,Gandini L,Cristiani C,Lombroso GC,Olivares MD,Wyssling H,Dondero F,Crosignani PG

    更新日期:1993-01-01 00:00:00

  • Is it safe to use a thermocautery device for circumcision? Examination of the histopathological changes emerging after thermocautery-assisted circumcisions.

    abstract::Multiple number of techniques and devices have been described concerning circumcision method so far. One of them is thermocautery device, and it has been widely used. Although there is controversy that the penis may be damaged due to the heat generated during the use of the device, not enough histopathological studies...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13968

    authors: Akyüz O,Tatar Z

    更新日期:2021-01-09 00:00:00

  • Dose-dependent protective effect of baicalin against testicular torsion-detorsion in rats.

    abstract::Testicular torsion/detorsion induces oxidative/nitrosative stress, inflammation and apoptosis of testicular tissues. Baicalin exerts antioxidant and anti-inflammatory properties. This study investigated the possible protective effect of baicalin against testicular torsion-detorsion injury in rats. Surgical testicular ...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.12580

    authors: Fouad AA,Qutub HO,Jresat I

    更新日期:2017-02-01 00:00:00

  • Retracted: Aetiology and clinical profile of children with 46, XY differences of sex development at an Indian referral centre.

    abstract::Retraction: 'Aetiology and clinical profile of children with 46, XY differences of sex development at an Indian referral centre' by Vasundhera Chauhan, Rima Dada, Vandana Jain The above article, published online on 8 August 2016 in Wiley Online Library (http://wileyonlinelibrary.com), has been retracted by agreement b...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.12663

    authors: Chauhan V,Dada R,Jain V

    更新日期:2017-11-01 00:00:00

  • Antiapoptotic effects of dehydroepiandrosterone on testicular torsion/detorsion in rats.

    abstract::In the present study, we aimed to evaluate the effects of dehydroepiandrosterone (DHEA) on apoptosis of testicular germ cells after repair of testicular torsion in rats. Twenty-four adult male Sprague-Dawley rats were randomly divided into four groups, with six rats in each group: sham operation, torsion/detorsion (T/...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.2008.00806.x

    authors: Yapanoglu T,Aksoy Y,Gursan N,Ozbey I,Ziypak T,Calik M

    更新日期:2008-02-01 00:00:00

  • Transition protein 1 mRNA expression is not related to pregnancy rate in azoospermic men undergoing TESE-ICSI.

    abstract::Our laboratory has previously reported significantly low levels of protamine (PRM) gene expression in infertile men. This drop was correlated with a low pregnancy rate, suggesting that PRMs may be useful as predictive factors for the outcome of testicular sperm extraction and intracytoplasmic sperm injection (TESE-ICS...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.2007.00775.x

    authors: Mitchell V,Lefebvre-Khalil V,Thomas P,Rigot JM,Steger K

    更新日期:2007-08-01 00:00:00

  • Acid-extracted glycoproteins in human seminal coagulum.

    abstract::Protein in intact coagulum of fresh human ejaculate was extracted by 0.25 N HCl, the condition used for extraction of sperm basic proteins. About 75% of the total coagulum protein was found to be acid-extractable and therefore so-called coagulum basic proteins (CBP). The CBP were glycosylated and entirely distinguisha...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1983.tb00158.x

    authors: Kusamran T,Surakarnkul R

    更新日期:1983-07-01 00:00:00

  • The physiology of male reproduction: Impact of drugs and their abuse on male fertility.

    abstract::Male factor accounts for about 30-50% of infertility. A common cause of male infertility is drug abuse; either illicit or prolonged use of prescribed drugs. This study provides a review of the physiology of the hypothalamic-pituitary-gonadal axis and recent literature on drugs that have been linked to male infertility...

    journal_title:Andrologia

    pub_type: 杂志文章,评审

    doi:10.1111/and.13672

    authors: Ajayi AF,Akhigbe RE

    更新日期:2020-10-01 00:00:00

  • [Sperm centrifugation in azoospermia?].

    abstract::In cases of azoospermia especially after vasectomy the investigation of the seminal sediment investigation is necessary. Exclusive on this way it is possible to find some side dispersed spermatozoa. The described case deals with a pregnancy about 48 days following vasectomy. Postoperative the sperm sediment investigat...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:

    authors: Schirren C

    更新日期:1984-07-01 00:00:00

  • Kisspeptin and RF9 prevent paroxetine-induced changes in some parameters of seminal vesicle fluid in the male rats.

    abstract::The aim of the study was to examine possible impacts of paroxetine and agomelatine on the levels of some components that constitute the seminal vesicle fluid. As a second purpose, it was also aimed to examine how possible negative effects induced by paroxetine on seminal vesicle fluid components were affected by kissp...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13538

    authors: Gulcu Bulmus F,Canpolat S,Sahin Z,Bulmus O,Serhatlioglu I,Kelestimur H

    更新日期:2020-05-01 00:00:00

  • Preparation and observation methods can produce misleading artefacts in human sperm ultrastructural morphology.

    abstract::The aim of this study was to evaluate the production of artefacts during preparation and observation of human sperm for ultrastructural morphology and analyse the possible reasons of causing these artefacts. Under the scanning electron microscopy, damaged sperm heads (crack or/and rupture), necks (head-neck or head-mi...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13043

    authors: Zhu WJ

    更新日期:2018-09-01 00:00:00

  • Causes of infertility in men with Down syndrome.

    abstract::Men with Down syndrome are considered as infertile although the causes of infertility are not known in detail yet. Although this constitutes a general rule there are three confirmed cases of parenting by fathers with Down syndrome. Many investigators have addressed the causes of infertility and their studies indicate ...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.2010.01043.x

    authors: Stefanidis K,Belitsos P,Fotinos A,Makris N,Loutradis D,Antsaklis A

    更新日期:2011-10-01 00:00:00

  • mTOR expression in human testicular seminoma.

    abstract::The mammalian target of rapamycin (TOR) has been implicated in the control of different stressors, growth factors, nutrients and hormones, participating in the control of key cellular functions. Controlling this many pathways poses mTOR signalling as a potential new target in new treatment strategies for multiple canc...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.12504

    authors: Yaba A,Bozkurt ER,Demir N

    更新日期:2016-08-01 00:00:00

  • Purification and characterization of angiotensin converting enzyme-II from bovine seminal plasma.

    abstract::Angiotensin converting enzyme (EC 3.4.15.1) from bovine seminal plasma was shown to exist in two distinct forms. A lower molecular weight form of the enzyme having higher activity was purified to homogeneity. Final recovery of the enzyme was 18.37%. The apparent molecular weight of the enzyme was estimated to be 1.99 ...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1991.tb02569.x

    authors: Sharma M,Singh US

    更新日期:1991-07-01 00:00:00

  • Progressively motile human spermatozoa are well protected against in vitro lipid peroxidation imposed by induced oxidative stress.

    abstract::Semen samples of 24 patients were analysed. Volumes were measured and the numbers of progressively motile (PMS), motile (MS) and nonmotile spermatozoa (NMS) were determined. These 24 samples appeared to show a large variation in motility percentages and numbers. Spermatozoa of these semen samples were isolated from th...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1046/j.1439-0272.2001.00430.x

    authors: Rhemrev JP,Vermeiden JP,Haenen GR,De Bruijne JJ,Rekers-Mombarg LT,Bast A

    更新日期:2001-05-01 00:00:00

  • Primary anastomosis of the traumatically amputated penis.

    abstract::Penile amputation is an uncommon condition for which immediate surgical replantation is warranted. This work aimed to represent intervention and management for an amputated penis by replantation and reconstruction. A 23-year-old man presented with traumatic penile amputation for 2 h where the penile proximal part was ...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.2009.00925.x

    authors: Salem HK,Mostafa T

    更新日期:2009-08-01 00:00:00