Abstract:
:Three new cases of low chiasma frequency in infertile men are described. In the first case, all cells showed abnormal diakineses; in the second, 20% of the diakineses were desynaptic, while the remaining 80% were normal; in the third, all diakineses were desynaptic and showed chromosome fragmentation. The possible mechanisms leading to asynapsis, desynapsis or precocious chiasma terminalization are discussed. :3 cases of low chiasma frequency associated with infertility in men are reported. Patients were 30-, 35-, and 38-years-old, respectively, and had normal secondary sex characteristics. Meiotic chromosomes were studied in testicular biopsies of 2 and in the semen of 1 patient. Semen analysis in the 1st patient revealed azoospermia with meiotic arrest at the 2nd spermatocyte level. Bivalent forming of 2 chiasmata were seen only occasionally. In the 2nd patient, oligo-astheno-teratozoospermia with piriform spermatozoa was revealed. Incomplete meiotic arrest was apparent at the spermatid level. 80% of the diakinetic cells were normal but there was an extremely low chiasma frequency in 20% of the 38 diakineses observed. The morphology was different than in the 1st case; chromosomes were more tightly coiled, bivalent frequently had 2 and 3 chiasmata and precocious separation of the small bivalents into univalents was more obvious. Semen analysis of the 3rd patient revealed poly-astheno-teratozoospermia. Meiotic preparations contained an extremely high number of metaphase 1 figures. Pairing abnormalities were present from early prophases 1. In metaphase 1 figures studied, chromosomal bodies appeared highly disorganized and fragmented. However, 1 or even 2 chiasmata were present. It is suggested that the anomalies seen result from asynapsis. Abnormal coiling may also be involved as might a defective regulatory mechanism of chiasma terminalization.
journal_name
Andrologiajournal_title
Andrologiaauthors
Templado C,Marina S,Egozcue Jdoi
10.1111/j.1439-0272.1976.tb01657.xkeywords:
subject
Has Abstractpub_date
1976-01-01 00:00:00pages
285-9issue
4eissn
0303-4569issn
1439-0272journal_volume
8pub_type
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