Novel predictive risk factor for Erectile Dysfunction: Serum folic acid.

Abstract:

:The purpose of this study was to compare the serum Folic Acid (FA) levels in patients with Erectile Dysfunction (ED) and healthy controls and whether levels vary with its severity. The study was carried out on 77 sexually active individuals, out of which 41 complained of ED and 36 were apparently normal. Patients were excluded if they had any diseases known to cause ED. The severity was further categorised based on IIEF-5 scores. Blood serum levels of testosterone, lipid profile, random blood sugar, liver function test, renal function test and FA levels were obtained in each patient. Independent-samples t test of significance was used when comparing between two means. Pearson's correlation coefficient (r) test was used for correlating data. All clinical and biochemical parameters except FA were comparable in both the groups. FA levels were significantly decreased in ED group (5.29 vs. 10.8; p value = .004). Smoking habits were comparable between the groups, and FA levels did not vary among smokers and nonsmokers (p value = .46). Serum FA levels significantly declined with increasing severity of ED (8.28 vs. 5.56 vs. 4.37 vs. 3.5; p value < .001). Thus, decreased FA might possibly be one of the novel risk factors for ED.

journal_name

Andrologia

journal_title

Andrologia

authors

Gupta A,Priyadarshi S,Vyas N,Sharma G,Swain PK

doi

10.1111/and.13890

subject

Has Abstract

pub_date

2021-02-01 00:00:00

pages

e13890

issue

1

eissn

0303-4569

issn

1439-0272

journal_volume

53

pub_type

杂志文章
  • Microvasculature of the human testis in correlation to Leydig cells and seminiferous tubules.

    abstract::The microvasculature of the human testis is closely related to the Leydig cells and the seminiferous tubules. Semi-thin sections of testicular tissue serve as a basis for the computer-aided 3-D reconstruction of the microvasculature, the seminiferous tubules and the Leydig cells. After vascular perfusion with glutaral...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1994.tb00799.x

    authors: Ergün S,Stingl J,Holstein AF

    更新日期:1994-09-01 00:00:00

  • Tramadol (opioid) abuse is associated with a dose- and time-dependent poor sperm quality and hyperprolactinaemia in young men.

    abstract::Tramadol, one of the most commonly abused drugs in Middle East, impacts spermatogenesis and disturbs reproductive hormones in animal studies. We aimed to investigate tramadol impact on sperm quality and on levels of testosterone, prolactin and gonadotropins, in tramadol abusers (n = 30) to age-matched control (n = 30)...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13026

    authors: Farag AGA,Basha MA,Amin SA,Elnaidany NF,Elhelbawy NG,Mostafa MMT,Khodier SA,Ibrahem RA,Mahfouz RZ

    更新日期:2018-08-01 00:00:00

  • Paternal lifestyle factors in relation to semen quality and in vitro reproductive outcomes.

    abstract::This prospective-cohort study aimed at investigating the influence of paternal lifestyle factors on semen parameters and intracytoplasmic sperm injection (ICSI) outcomes. The influence of paternal lifestyle factors on seminal quality and ICSI outcomes was investigated in male patients undergoing conventional semen ana...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13090

    authors: Borges E Jr,Braga DPAF,Provenza RR,Figueira RCS,Iaconelli A Jr,Setti AS

    更新日期:2018-11-01 00:00:00

  • Serum sperm agglutinating antibody formation in vasectomized men treated with dexamethasone.

    abstract::The effect of immunosuppression with dexamethasone on sperm antibody formation following vasectomy in men was determined. Vasectomized men were treated with dexamethasone (4 mg) tablets starting two days prior to vasectomy and each day thereafter for a total of eight days for a total dose of 30 mg. There was no signif...

    journal_title:Andrologia

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1439-0272.1987.tb01907.x

    authors: Curtis GL,Kahl VA,Ryan WL

    更新日期:1987-11-01 00:00:00

  • Genetic analysis of HOXA11 gene in Chinese patients with cryptorchidism.

    abstract::Cryptorchidism is the most common congenital anomaly in male children. Its aetiology remains unknown in the majority of cases. Because HOXA11 plays a vital role in regulating testicular descent, genetic variants in HOXA11 genes may contribute to the risk of cryptorchidism. In this study, mutation analysis was performe...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.12790

    authors: Lu P,Wang Y,Wang F,Huang J,Zeng Y,He D,Huang H,Cheng Z

    更新日期:2018-02-01 00:00:00

  • Genetic analysis of the human Insulin-like 3 gene: absence of mutations in a Greek paediatric cohort with testicular maldescent.

    abstract::This study investigated the hypothesis that genetic alterations of the human insulin-like 3 (INSL3) gene are associated with testicular maldescent (TMD). Genomic DNA was extracted and amplified from peripheral blood samples of 170 unrelated children with all possible phenotypical expressions of TMD and 50 volunteers w...

    journal_title:Andrologia

    pub_type: 杂志文章,评审

    doi:10.1111/and.12184

    authors: Mamoulakis C,Georgiou I,Dimitriadis F,Tsounapi P,Giannakis I,Chatzikyriakidou A,Antypas S,Sofras F,Takenaka A,Sofikitis N

    更新日期:2014-01-01 00:00:00

  • Profertility effects of Shilajit on cadmium-induced infertility in male mice.

    abstract::Shilajit is claimed as a Vajikarak (aphrodisiac) and used for the treatment of male infertility by traditional healers of the Indian subcontinent. Therefore, the present investigation was designed to assess the effectiveness of Shilajit for treatment of male infertility resulting from exposure to perilous chemicals. E...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13064

    authors: Mishra RK,Jain A,Singh SK

    更新日期:2018-10-01 00:00:00

  • Three cases of low chiasma frequency associated with infertility in man.

    abstract::Three new cases of low chiasma frequency in infertile men are described. In the first case, all cells showed abnormal diakineses; in the second, 20% of the diakineses were desynaptic, while the remaining 80% were normal; in the third, all diakineses were desynaptic and showed chromosome fragmentation. The possible mec...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1976.tb01657.x

    authors: Templado C,Marina S,Egozcue J

    更新日期:1976-01-01 00:00:00

  • Relationship of thyroid to estramustine binding protein (EMBP) concentration in rat prostate.

    abstract::Alternations of estramustine binding protein (EMBP) concentration in rat prostate in relation to androgen status under hypo- and hyperthyroid conditions was estimated by means of radioimmunoassay (RIA). In hyperthyroid rats, EMBP concentration in dorsal as well as in lateral prostate was not significantly changed, but...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1991.tb02518.x

    authors: Shiina H,Sumi H,Ishibe T,Usui T

    更新日期:1991-03-01 00:00:00

  • Aqueous and ethanol extracts of Dracaena arborea (Wild) Link (Dracaenaceae) alleviate reproductive complications of diabetes mellitus in rats.

    abstract::Reproductive dysfunction is one of the most prevalent diabetes complications. Draceana arborea is known to enhance sexual function in diabetic rats, but the underlying mechanisms have not been thoroughly elucidated. This study examined the effects of D. arborea on some reproductive complications of diabetes in rats. A...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13381

    authors: Wankeu-Nya M,Watcho P,Deeh Defo PB,Ngadjui E,Nguelefack TB,Kamtchouing P,Kamanyi A

    更新日期:2019-11-01 00:00:00

  • Personality, coping and sperm count.

    abstract::Previous research has suggested an association between personality traits and coping, as well as between coping and sperm concentration. In the present study, both domains of research were combined, leading to the formulation of specific hypotheses. A total of 54 healthy volunteers were given questionnaires twice to a...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.2004.00647.x

    authors: Pook M,Tuschen-Caffier B,Kubek J,Schill WB,Krause W

    更新日期:2005-02-01 00:00:00

  • [Evaluation of semen by electronic spermcounter].

    abstract::The new electronic spermcounter was developed to make andrological routine work easier. The apparatus is a complete microcomputer and has three main functions: The counter function allows to determine the number of spermatozoa and round cells at the same time. The morphological function allows the detailed morphologic...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:

    authors: Pusch H,Wiesspeiner G,Hausl A

    更新日期:1982-03-01 00:00:00

  • Development of primordial germ cells in the mouse.

    abstract::Primordial germ cells in the mouse are known to be derived from the epiblast. They can be identified histochemically, by their high alkaline phosphatase activity. At 8 d post coitum they have been observed within the embryonic part of the egg cylinder, at the posterior end of the primitive streak. Earlier, at 7.25 day...

    journal_title:Andrologia

    pub_type: 杂志文章,评审

    doi:10.1111/j.1439-0272.1992.tb02647.x

    authors: McLaren A

    更新日期:1992-09-01 00:00:00

  • Ethanol-induced mitophagy in rat Sertoli cells: Implications for male fertility.

    abstract::Autophagy is a pro-survival mechanism involving lysosomal degradation of damaged cellular components following multiple forms of cellular stress. There is currently a lack of literature on the mechanism, and specifically on mitophagy (selective autophagy of damaged pro-apoptotic mitochondria) in Sertoli cells (SCs). A...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.12820

    authors: Eid N,Kondo Y

    更新日期:2018-02-01 00:00:00

  • A rare case report: Penile lipoma after hypospadias repair.

    abstract::Lipomas are the most common benign tumours that originate from adipose tissue and can develop in any anatomical location where the adipose tissue layer is present in the body. Penile lipoma cases are very rare in the literature. Our case is a 21-year-old male patient who underwent TIPU operation 8 years ago due to dis...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13289

    authors: Ogras MS,Oguz E,Yildirim K

    更新日期:2019-07-01 00:00:00

  • [Determination of the frequency of Y-chromatin positive spermatozoa in relation to the parameters of spermiograms].

    abstract::The percentage of y chromatin positive spermatozoa had been determined using the fluorescence microsopce technique. After staining procedure with Atebrin we counted 44.1 (+/- 3.9)% y poistive sperms, after staining with Quinacrine mustard the amount was 48,4 (+/- 4,3)%. With statistical methods we examined the correla...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:

    authors: Kaiser R,Herrmann WP,Broer KH,Fischer W

    更新日期:1977-01-01 00:00:00

  • Significance of CFTR gene mutations in patients with congenital aplasia of vas deferens with special regard to renal aplasia.

    abstract::Between 1994 and 2010, a total of 123 patients with obstructive azoospermia due to aplasia of vas deferens (CAVD) were surgically treated. In 110 patients, the condition was bilateral (CBAVD), 13 men had unilateral aplasia (CUAVD), and 10 patients additionally had aplasia of one kidney. All patients underwent CFTR gen...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.2012.01281.x

    authors: Schwarzer JU,Schwarz M

    更新日期:2012-10-01 00:00:00

  • A human morphologically normal spermatozoon may have noncondensed chromatin.

    abstract::According to numerous assisted reproductive medicine practitioners, semen with normal characteristics might not require further investigation. However, on the scale of the individual spermatozoon, it is well known that normal morphology does not guarantee optimal nuclear quality. Here, for 20 patients with normal sper...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.12341

    authors: Boitrelle F,Pagnier M,Athiel Y,Swierkowski-Blanchard N,Torre A,Alter L,Muratorio C,Vialard F,Albert M,Selva J

    更新日期:2015-10-01 00:00:00

  • Chloroquine excretion in semen following antimalarial-drug administration.

    abstract::The study described here was carried out to establish whether or not chloroquine was excreted in semen. Chloroquine was assayed in the semen of eight male volunteers (aged between 19 and 45 years) by a fluorimetric method before and after taking a total dose of 1.500 mg chloroquine base corresponding to the accepted d...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1994.tb00782.x

    authors: Adeeko AO,Dada OA

    更新日期:1994-05-01 00:00:00

  • [Attempts at localisation and evaluation of the RNA amounts in the tail and the cytoplasmic droplet of bull spermatozoa].

    abstract::The RNA has been located and proportioned by a spectrophotometric method which absorbs the ultra-violet light. The technique used allows us to execute punctual dosage into the spermatozoon's tail. Each of these punctual dosages makes us realise the RNA localisation; and the sum of these dosages makes us realise the to...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:

    authors: Henriet L

    更新日期:1975-01-01 00:00:00

  • Correlation between gamma seminoprotein in seminal plasma and ejaculate parameters.

    abstract::Gamma seminoprotein (G-SM) levels in seminal plasma were determinated in 62 ejaculates using an enzymimmunoassay. There was no statistical significant difference in G-SM between men with normozoospermia (n = 14), asthenozoospermia (n = 17), OAT-syndrome (n = 18) and azoospermia (n = 13). Also there was no correlation ...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1991.tb02502.x

    authors: Maier U,Simak R

    更新日期:1991-01-01 00:00:00

  • Increased plasminogen activator activity and plasminogen activator inhibition in spermatozoa and seminal plasma of the ram after serum gonadotrophin (PMSG) administration. Correlation with the increased level of testosterone in the blood.

    abstract::After a single injection of serum gonadotrophin (PMSG) at the dose of 15 IU/kg, i.m. into rams testosterone in the plasma of blood showed a significant rise between 4th and 7th day post-injection. At the same time (4th-7th day) the plasminogen activator activity (PAA) in seminal plasma was found to be increased, but t...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1991.tb02559.x

    authors: Rekkas C,Belibasaki S,Taitzoglou I,Kokolis N,Smokovitis A

    更新日期:1991-07-01 00:00:00

  • Rat sperm immobilisation effects of a protein from Ricinus communis (Linn.): an in vitro comparative study with nonoxynol-9.

    abstract::Previous study conducted in our department showed that 50% ethanolic extract of the root of Ricinus communis possess reversible antifertility effect and a 62-kDa protein (Rp) from this extract is responsible for the antifertility effects. In this study, we compared the spermicidal effect of this Rp with nonoxynol-9 (N...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.2012.01291.x

    authors: Nithya RS,Anuja MM,Rajamanickam C,Indira M

    更新日期:2012-12-01 00:00:00

  • Disorder of hypothalamic-pituitary-gonadal axis induced by abusing of anabolic-androgenic steroids for short time: A case report.

    abstract::The aim of this study was to evaluate the hypothalamic-pituitary-gonadal axis functionality on a bodybuilding competitioner before, during and after the use of anabolic-androgenic steroids. A young healthy man was followed up for 4 months. The subject reported his drug administration protocol through periodic intervie...

    journal_title:Andrologia

    pub_type:

    doi:10.1111/and.13107

    authors: Vilar Neto JO,da Silva CA,Lima AB,Caminha JSR,Pinto DV,Alves FR,Araújo JS,Daher EF

    更新日期:2018-11-01 00:00:00

  • Embryonic exposure to dimethoate and/or deltamethrin impairs sexual development and programs reproductive success in adult male offspring mice.

    abstract::Pesticides can be toxic to desirable plants and animals, including humans. The aim of this study was to investigate the reproductive effects of low doses of pesticides on male offspring of exposed pregnant mice. Three groups of five female mice were treated daily by oral gavage with dimethoate (5 mg kg(-1) per day), d...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.2011.01246.x

    authors: Ben Slima A,Ben Abdallah F,Keskes-Ammar L,Mallek Z,El Feki A,Gdoura R

    更新日期:2012-05-01 00:00:00

  • Seminal parameters of chronic male genital inflammation are associated with disturbed sperm DNA integrity.

    abstract::Definition of chronic male genital tract inflammation and its impact on male infertility is still a matter of debate. In particular, DNA integrity has been reported to be disturbed in subfertile men. Thus, the aim of this study was to investigate an association of DNA integrity to altered standard semen parameters as ...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.12408

    authors: Haidl F,Haidl G,Oltermann I,Allam JP

    更新日期:2015-05-01 00:00:00

  • Kruger strict morphology and post-thaw progressive motility in cryopreserved human spermatozoa.

    abstract::The purpose of this prospective study was to evaluate Kruger strict morphology and conventional semen analysis in predicting cryosurvival and the progressive motility recovery rate of frozen spermatozoa. Our study included 56 semen samples with >10 million spermatozoa per ejaculate. The main outcome measures were conv...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.2010.01141.x

    authors: Lee CY,Lee CT,Wu CH,Hsu CS,Hsu MI

    更新日期:2012-05-01 00:00:00

  • Effects of continuous long-term testosterone therapy (TTh) on anthropometric, endocrine and metabolic parameters for up to 10 years in 115 hypogonadal elderly men: real-life experience from an observational registry study.

    abstract::Subnormal levels of testosterone are associated with significant negative health consequences, with higher risks of all-cause and cardiovascular mortality. The numbers of studies reporting on the benefits of normalisation of testosterone is increasing but longer-term data on (elderly) men receiving testosterone treatm...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.12514

    authors: Yassin AA,Nettleship J,Almehmadi Y,Salman M,Saad F

    更新日期:2016-09-01 00:00:00

  • Parameters predicting sperm retrieval rates during microscopic testicular sperm extraction in nonobstructive azoospermia.

    abstract::The aim of this study was to investigate the predictive value of the parameters that might have an effect on the success of microscopic testicular sperm extraction (micro-TESE) in infertile patients with nonobstructive azoospermia (NOA). Between 2003 and 2014, 860 patients with NOA were retrospectively analysed. The e...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13441

    authors: Kizilkan Y,Toksoz S,Turunc T,Ozkardes H

    更新日期:2019-12-01 00:00:00

  • Quercetin mitigates fenitrothion-induced testicular toxicity in rats.

    abstract::Fenitrothion (FNT) is a widely used organophosphorus pesticide in agriculture. Quercetin (QR), a plant-derived flavonoid, has a free radical scavenging property. This study investigated the protective effect of QR on FNT-induced testicular toxicity in rats. Twenty-four male rats were divided into four groups. Group I ...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.12467

    authors: Saber TM,Abd El-Aziz RM,Ali HA

    更新日期:2016-06-01 00:00:00