Abstract:
:According to numerous assisted reproductive medicine practitioners, semen with normal characteristics might not require further investigation. However, on the scale of the individual spermatozoon, it is well known that normal morphology does not guarantee optimal nuclear quality. Here, for 20 patients with normal sperm characteristics and a high proportion of spermatozoa with noncondensed chromatin, we subsequently assessed chromatin condensation status (aniline blue staining) and morphology (Papanicolaou staining) of the same 3749 spermatozoa. Although the overall proportion of morphologically normal spermatozoa was not correlated with the overall proportion of spermatozoa with noncondensed chromatin, an individual spermatozoon's morphology appeared to be closely related to its chromatin condensation status. Morphologically normal spermatozoa with noncondensed chromatin were seen in all patients; the proportion averaged 23.3% [min 10.9%-max 44.4%]. Morphologically abnormal spermatozoa were more likely to have noncondensed chromatin than morphologically normal ones (P < 0.0001). Small-, large- or multiple-headed spermatozoa presented the highest degree of noncondensation (>80% for each type), and more than half the vacuolated spermatozoa also presented noncondensed chromatin. However, a morphologically normal spermatozoon may also have a noncondensed chromatin.
journal_name
Andrologiajournal_title
Andrologiaauthors
Boitrelle F,Pagnier M,Athiel Y,Swierkowski-Blanchard N,Torre A,Alter L,Muratorio C,Vialard F,Albert M,Selva Jdoi
10.1111/and.12341subject
Has Abstractpub_date
2015-10-01 00:00:00pages
879-86issue
8eissn
0303-4569issn
1439-0272journal_volume
47pub_type
杂志文章相关文献
ANDROLOGIA文献大全abstract::The application of assisted reproductive technologies (ART) has revolutionised the treatment of human infertility, giving hope to the patients previously considered incapable of establishing pregnancy. While semen analysis is performed to access whether a sample has an adequate number of viable, motile and morphologic...
journal_title:Andrologia
pub_type: 杂志文章,评审
doi:10.1111/and.13725
更新日期:2020-06-28 00:00:00
abstract::In 20 autoptically obtained testes from men of various ages, 250-290 testicular lobules per testicle could be recognized by preparation with a stereomicroscope. The most appropriate technique was the fixation of the testes in 10% formol for at least 14 days and a following dehydration in a series of increasing concent...
journal_title:Andrologia
pub_type: 杂志文章
doi:
更新日期:1985-11-01 00:00:00
abstract::This study was conducted to evaluate the effects of ivermectin (IVM) with therapeutic dose (injected with 0.56 mg/kg b.wt.) either alone or combined with alpha lipoic acid (ALA) (50 mg/kg b.wt daily) on expression of testicular insulin-like growth factor binding protein-3 (IGFBP-3) and heat-shock protein A1 (HSPA1)) g...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.12891
更新日期:2018-04-01 00:00:00
abstract::The total amount of humoral sperm antibody protein is determined following its isolation by affinity-chromatography on spermatozoa. Serum proteins are eluted by Sorensen phosphate buffer. Antibodies attached to spermatozoa suspended in Sephadex G 75 columns resist elution by Sorensen buffer. They can be quantitatively...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1975.tb01236.x
更新日期:1975-01-01 00:00:00
abstract::The aim of this study was to determine the effect(s) of dietary omega-3 polyunsaturated fatty acids (ω-3 PUFA) on rabbit semen. Adult rabbit bucks were assigned to two groups that were given two diets, a standard diet (control) and a diet supplemented with ω-3 PUFA. Sperm samples were collected from all bucks with the...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.12776
更新日期:2017-12-01 00:00:00
abstract::The RNA has been located and proportioned by a spectrophotometric method which absorbs the ultra-violet light. The technique used allows us to execute punctual dosage into the spermatozoon's tail. Each of these punctual dosages makes us realise the RNA localisation; and the sum of these dosages makes us realise the to...
journal_title:Andrologia
pub_type: 杂志文章
doi:
更新日期:1975-01-01 00:00:00
abstract::The spontaneous contractility of the rat epididymis was recorded in vivo and the effects of cyproterone acetate were studied. At 7 days after cyproterone acetate daily administration the records of the epididymal contractility did not show significant differences from the records obtained in control animals. On the co...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1977.tb01682.x
更新日期:1977-10-01 00:00:00
abstract::Reproductive dysfunction is one of the most prevalent diabetes complications. Draceana arborea is known to enhance sexual function in diabetic rats, but the underlying mechanisms have not been thoroughly elucidated. This study examined the effects of D. arborea on some reproductive complications of diabetes in rats. A...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13381
更新日期:2019-11-01 00:00:00
abstract::Twenty infertile patients with normal tubal patency were inseminated intraperitoneally (11 once, seven twice, and two three times) with spermatozoa (mean 14 x 10(6), range 0.6-48 x 10(6)) prepared by the standard swim-up technique. The occurrence of immunization to spermatozoa was looked for by the Gelatin Agglutinati...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1993.tb02673.x
更新日期:1993-01-01 00:00:00
abstract::The hypothalamic-pituitary-testicular axis and the regulation of prolactin secretion were investigated in eleven male renal transplant recipients. Mean serum levels of testosterone and estrone were normal, whereas those of androstenedione and estradiol were low. Mean basal luteinizing hormone (LH) levels were slightly...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1988.tb00670.x
更新日期:1988-03-01 00:00:00
abstract::To obtain optimal results with gonadotrophic therapy (HMG/hCG) in infertile males, strict selection of patients is of paramount importance. The use of algorithmic schemes permits the exclusion of patients with primary testicular failure, genetic and non-endocrine causes of infertility. This paper describes a retrospec...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1979.tb02216.x
更新日期:1979-09-01 00:00:00
abstract::Liquid nitrogen preservation in remote farms is a limitation. The goal of this study was to determine optimum temperature above freezing point for bovine spermatozoa preservation using bovine serum albumin (BSA) as a supplementation. Pooled semen sample from three ejaculates was subjected to various BSA concentration ...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.2011.01203.x
更新日期:2012-05-01 00:00:00
abstract::Our aim was to compare peripheral blood and seminal fluid serum amyloid A (SAA) protein levels in men classified on the basis of sperm concentration and investigate whether SAA protein is an important marker of male infertility. A total of 74 first-attempt IVF male partners of infertile couples classified as azoosperm...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.12491
更新日期:2016-08-01 00:00:00
abstract::A substantial body of evidence has accumulated in recent years that human semen quality may be deteriorating. This has been associated with evidence of other changes in male reproductive health, including increases in congenital malformations and testicular cancer in humans, and similar problems in wildlife. Unfortuna...
journal_title:Andrologia
pub_type: 杂志文章,评审
doi:10.1046/j.1439-0272.2000.00388.x
更新日期:2000-09-01 00:00:00
abstract::Previous studies have shown that alpha1-adrenergic receptor antagonists may alter seminal vesicle contractility and impair fertility in male rats. This study was designed to investigate the effects of terazosin on the catalase expression in the seminal vesicles and the lipid peroxidation of the seminal fluid in normal...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.2012.01324.x
更新日期:2013-04-01 00:00:00
abstract::The purpose of our analysis is to identify the effect of l-carnitine (LC) and l-acetyl carnitine (LAC) on the semen parameters of men with idiopathic oligoasthenoteratozoospermia (iOAT). We performed a comprehensive search to ascertain all the trials about LC and LAC in the treatment of iOAT and compared the results, ...
journal_title:Andrologia
pub_type: 杂志文章,meta分析
doi:10.1111/and.13470
更新日期:2020-03-01 00:00:00
abstract::Cryptorchidism is the most common congenital anomaly in male children. Its aetiology remains unknown in the majority of cases. Because HOXA11 plays a vital role in regulating testicular descent, genetic variants in HOXA11 genes may contribute to the risk of cryptorchidism. In this study, mutation analysis was performe...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.12790
更新日期:2018-02-01 00:00:00
abstract::Previous study conducted in our department showed that 50% ethanolic extract of the root of Ricinus communis possess reversible antifertility effect and a 62-kDa protein (Rp) from this extract is responsible for the antifertility effects. In this study, we compared the spermicidal effect of this Rp with nonoxynol-9 (N...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.2012.01291.x
更新日期:2012-12-01 00:00:00
abstract::The sex chromosome-discordant chimerism 46,XX/46,XY is rarely found in humans with a phenotypically normal appearance, and this lack of phenotypic changes and the rarity of chimerism make it difficult to identify its exact incidence. Here, we report a case of this sex chromosome-discordant chimerism diagnosed by cytog...
journal_title:Andrologia
pub_type:
doi:10.1111/and.13215
更新日期:2019-04-01 00:00:00
abstract::Flutamide is a steroid used to treat androgen-dependent disorders and as antiepileptic, but it induces a number of non-desirable side effects. This work was aimed at assaying the effect of flutamide and two novel synthetic steroids on the levels of GABA, glutamine and oxidative stress markers. Male Wistar rats (weight...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.2010.01051.x
更新日期:2011-08-01 00:00:00
abstract::On the basis of microscopical examination and further differentiation by special stain techniques, a new classification of defects of midpieces and tails of spermatozoa will be presented: First degree disorders i.e. abnormalities of the staining behaviour and minor structural defects, second degree disorders revealing...
journal_title:Andrologia
pub_type: 杂志文章
doi:
更新日期:1987-07-01 00:00:00
abstract::The study investigated the association between lower urinary tract symptoms (LUTS) and sexual dysfunction in ageing men. It was a cross-sectional study in an unselected consecutive sample of 398 men aged >40 years attending a urology clinic. LUTS and sexual function were assessed by validated symptom scales, including...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.2008.00876.x
更新日期:2008-12-01 00:00:00
abstract::Analysis of seminal fluid samples from 20 ADS cases is reported for the first time. A significant decrease in the total volume of complete semen sample and sperm concentration was observed. Percentage of morphologically abnormal sperms was higher in samples from ADS cases than controls, though no linear correlation wa...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1985.tb01714.x
更新日期:1985-11-01 00:00:00
abstract::The results of a study of 373 cases of male sterility in Tunisia are presented. Factors with negative effects on fertility are listed according to their incidence: hypogonadism, gonococci infection, following varicocele and excessive smoking. Important is; early diagnosis of venereal disease and its effective treatmen...
journal_title:Andrologia
pub_type: 杂志文章
doi:
更新日期:1987-06-01 00:00:00
abstract::Pesticides can be toxic to desirable plants and animals, including humans. The aim of this study was to investigate the reproductive effects of low doses of pesticides on male offspring of exposed pregnant mice. Three groups of five female mice were treated daily by oral gavage with dimethoate (5 mg kg(-1) per day), d...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.2011.01246.x
更新日期:2012-05-01 00:00:00
abstract::The synthetic androgen mibolerone elicits a set of distinct changes in the behaviour of an androgen responsive human prostatic carcinoma cell line (LNCaP). Inhibition of cell proliferation, induction of morphological change and of a prostate specific mRNA, and inhibition of colony formation in soft agar are induced by...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1990.tb02071.x
更新日期:1990-01-01 00:00:00
abstract::A careful history and evaluation of men with chronic orchialgia elucidates the aetiology in some men to be a hyperactive cremaster muscle reflex with testicular retraction as the cause. The objective is to evaluate outcomes in men who underwent microsurgical subinguinal cremaster muscle release (MSCMR) with a retrospe...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13493
更新日期:2020-02-01 00:00:00
abstract::The aim of this study was to access whether microsurgical subinguinal varicocelectomy (MSV) with testicular delivery has a better therapeutic effect than MSV without testicular delivery, including semen quality, serum testosterone (T) level and International Index of Erectile Function (IIEF)-5 score in infertility mal...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13605
更新日期:2020-07-01 00:00:00
abstract::Primary seminal vesicle adenocarcinoma is a rare malignancy of the male genito-urinary system with only a few confirmed reported cases. Initial tissue diagnostic modality is often a core biopsy specimen. Here, we report this rare entity in a 50-year-old male, highlighting the histomorphological and immunohistochemical...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13512
更新日期:2020-04-01 00:00:00
abstract::Two groups of 5 rabbits were actively immunized with porcine relaxin or sham immunized. Serial analysis of sperm motion characteristics using the computer assisted Hamilton-Thorn Motility Analyzer over a period of 22 weeks did not reveal any significant antibody titers in serum and seminal plasma. In consideration of ...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1990.tb01961.x
更新日期:1990-03-01 00:00:00