Abstract:
:The synthetic androgen mibolerone elicits a set of distinct changes in the behaviour of an androgen responsive human prostatic carcinoma cell line (LNCaP). Inhibition of cell proliferation, induction of morphological change and of a prostate specific mRNA, and inhibition of colony formation in soft agar are induced by very low concentrations of mibolerone. The natural androgen dihydrotestosterone is much less effective. The changes in growth characteristics and morphology are reverted by excess antiandrogen, i.e. cyproterone acetate or hydroxyflutamide. Cell lines lacking androgen receptors (PC-3, DU 145 and MRC-5) are completely unresponsive to mibolerone. Taken together, our results indicate androgen receptor mediated suppression of the transformed phenotype in LNCaP cells.
journal_name
Andrologiajournal_title
Andrologiaauthors
Schulz P,Wolf D,Arbusow V,Bojar H,Klobeck HG,Fittler Fdoi
10.1111/j.1439-0272.1990.tb02071.xsubject
Has Abstractpub_date
1990-01-01 00:00:00pages
56-66eissn
0303-4569issn
1439-0272journal_volume
22 Suppl 1pub_type
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