The synthetic androgen mibolerone induces transient suppression of the transformed phenotype in an androgen responsive human prostatic carcinoma cell line.

Abstract:

:The synthetic androgen mibolerone elicits a set of distinct changes in the behaviour of an androgen responsive human prostatic carcinoma cell line (LNCaP). Inhibition of cell proliferation, induction of morphological change and of a prostate specific mRNA, and inhibition of colony formation in soft agar are induced by very low concentrations of mibolerone. The natural androgen dihydrotestosterone is much less effective. The changes in growth characteristics and morphology are reverted by excess antiandrogen, i.e. cyproterone acetate or hydroxyflutamide. Cell lines lacking androgen receptors (PC-3, DU 145 and MRC-5) are completely unresponsive to mibolerone. Taken together, our results indicate androgen receptor mediated suppression of the transformed phenotype in LNCaP cells.

journal_name

Andrologia

journal_title

Andrologia

authors

Schulz P,Wolf D,Arbusow V,Bojar H,Klobeck HG,Fittler F

doi

10.1111/j.1439-0272.1990.tb02071.x

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

56-66

eissn

0303-4569

issn

1439-0272

journal_volume

22 Suppl 1

pub_type

杂志文章
  • Correlation of biochemical constituents of seminal plasma with semen quality in Teddy goat (Capra hircus) bucks.

    abstract::This study was planned to determine the relationship between semen quality parameters and the levels of biochemical constituents of seminal plasma of Teddy (Capra hircus) buck semen. For this purpose, semen ejaculates were collected from five mature healthy Teddy bucks. All the experimental bucks were kept under natur...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.12940

    authors: Umar S,Ahmad M,Ahmad I,Zubair M,Umar Z,Qureshi AS,Manzoor A,Murtaza A,Shaukat A

    更新日期:2018-04-01 00:00:00

  • Association of XRCC1 and ERCC2 promoters' methylation with chromatin condensation and sperm DNA fragmentation in idiopathic oligoasthenoteratozoospermic men.

    abstract::The aim of the study was to investigate whether the promoter methylation of XRCC1 and ERCC2 genes is associated with sperm DNA fragmentation and chromatin condensation in idiopathic oligoasthenoteratozoospermic men. This study involved 77 infertile men with idiopathic oligoasthenoteratozoospermia and 51 normozoospermi...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13925

    authors: Metin Mahmutoglu A,Gunes S,Asci R,Henkel R,Aydin O

    更新日期:2020-12-23 00:00:00

  • [Male infertility in Tunisia: apropos of 373 cases].

    abstract::The results of a study of 373 cases of male sterility in Tunisia are presented. Factors with negative effects on fertility are listed according to their incidence: hypogonadism, gonococci infection, following varicocele and excessive smoking. Important is; early diagnosis of venereal disease and its effective treatmen...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:

    authors: Jaballah N

    更新日期:1987-06-01 00:00:00

  • Effects of ivermectin and its combination with alpha lipoic acid on expression of IGFBP-3 and HSPA1 genes and male rat fertility.

    abstract::This study was conducted to evaluate the effects of ivermectin (IVM) with therapeutic dose (injected with 0.56 mg/kg b.wt.) either alone or combined with alpha lipoic acid (ALA) (50 mg/kg b.wt daily) on expression of testicular insulin-like growth factor binding protein-3 (IGFBP-3) and heat-shock protein A1 (HSPA1)) g...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.12891

    authors: El-Maddawy ZK,Abd El Naby WSH

    更新日期:2018-04-01 00:00:00

  • Deregulation of Aurora kinase gene expression in human testicular germ cell tumours.

    abstract::The Aurora kinases regulate chromosome segregation and cytokinesis, and alterations in their expression associate with cell malignant transformation. In this study, we demonstrated by qRT-PCR analysis of 14 seminomas that Aurora-A mRNA was, with respect to control tissues, augmented in five of 14 tumour tissues by 2.1...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.2009.00987.x

    authors: Baldini E,Arlot-Bonnemains Y,Mottolese M,Sentinelli S,Antoniani B,Sorrenti S,Salducci M,Comini E,Ulisse S,D'Armiento M

    更新日期:2010-08-01 00:00:00

  • Effect of ghrelin on total antioxidant capacity, lipid peroxidation, sperm parameters and fertility in mice against oxidative damage caused by cyclophosphamide.

    abstract::Cyclophosphamide is a drug used for chemotherapy and as an immune-suppressive in the organ transplantation. Despite its many clinical implications in the treatment of cancers, this drug has toxic effects on the reproductive system. This study aimed to evaluate the effect of ghrelin against the damages caused by cyclop...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.12883

    authors: Salimnejad R,Soleimani Rad J,Mohammad Nejad D,Roshangar L

    更新日期:2018-03-01 00:00:00

  • Reproductive immunology: 4. The effect of seminal plasma from immunologic infertile men on in vitro lymphocyte cultures.

    abstract::The seminal plasma of 31 patients were examined for the presence of sperm antibodies and for inhibitory properties on the transformation rates of donor lymphocytes cultured in vitro. Twenty five (80%) of the men revealed apart from fertile semen, no sperm antibody activities while six (20%) patients showed high sperma...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1982.tb03105.x

    authors: Franken DR,Slabber CF

    更新日期:1982-03-01 00:00:00

  • [Morphologic studies of spermatozoa in disorders of motility].

    abstract::On the basis of microscopical examination and further differentiation by special stain techniques, a new classification of defects of midpieces and tails of spermatozoa will be presented: First degree disorders i.e. abnormalities of the staining behaviour and minor structural defects, second degree disorders revealing...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:

    authors: Haidl G,Hartmann R,Hofmann N

    更新日期:1987-07-01 00:00:00

  • Enzyme levels in semen of men with different types of azoospermia.

    abstract::The levels of eight enzymes have been measured in the semen of 15 azoospermic subjects. The results indicate that the values of the enzymes Creatine kinase, and Alanine aminotransferase, just as the Aspartate aminotransferase/Alanine aminotransferase ratio are significantly different between excretory and secretory az...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1982.tb03099.x

    authors: Gonzalez Buitrago JM,Garcia Diez LC

    更新日期:1982-01-01 00:00:00

  • Prevalence of low serum cobalamin in infertile couples.

    abstract::A high prevalence of low levels of cobalamin had been found in a survey of multi-ethnic normal individuals in Israel. The purpose of this study was to investigate the incidence of cobalamin deficiency among Israeli couples suffering from infertility. All couples seen at the in vitro fertilization clinic at an urban ho...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.2008.00895.x

    authors: Pront R,Margalioth EJ,Green R,Eldar-Geva T,Maimoni Z,Zimran A,Elstein D

    更新日期:2009-02-01 00:00:00

  • Embryonic exposure to dimethoate and/or deltamethrin impairs sexual development and programs reproductive success in adult male offspring mice.

    abstract::Pesticides can be toxic to desirable plants and animals, including humans. The aim of this study was to investigate the reproductive effects of low doses of pesticides on male offspring of exposed pregnant mice. Three groups of five female mice were treated daily by oral gavage with dimethoate (5 mg kg(-1) per day), d...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.2011.01246.x

    authors: Ben Slima A,Ben Abdallah F,Keskes-Ammar L,Mallek Z,El Feki A,Gdoura R

    更新日期:2012-05-01 00:00:00

  • The relationship between ejaculated ram sperm mitochondrial protein synthesis and motility.

    abstract::D-chloramphenicol, at concentrations of 20 and 40 micrograms/ml, inhibited over 80% of the newly synthesized mitochondrial proteins expressed by incorporation of 3H-amino acid mixture. At concentrations of 20 and 40 micrograms ml-1, D-chloramphenicol enhanced the collective motility of washed ram spermatozoa. The coll...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1994.tb00815.x

    authors: Twaina-Bechor E,Bartoov B

    更新日期:1994-11-01 00:00:00

  • Genetic analysis of the human Insulin-like 3 gene: absence of mutations in a Greek paediatric cohort with testicular maldescent.

    abstract::This study investigated the hypothesis that genetic alterations of the human insulin-like 3 (INSL3) gene are associated with testicular maldescent (TMD). Genomic DNA was extracted and amplified from peripheral blood samples of 170 unrelated children with all possible phenotypical expressions of TMD and 50 volunteers w...

    journal_title:Andrologia

    pub_type: 杂志文章,评审

    doi:10.1111/and.12184

    authors: Mamoulakis C,Georgiou I,Dimitriadis F,Tsounapi P,Giannakis I,Chatzikyriakidou A,Antypas S,Sofras F,Takenaka A,Sofikitis N

    更新日期:2014-01-01 00:00:00

  • Evaluation of effectiveness of antiandrogen treatments on cavernosal tissues in rats.

    abstract::In this study, we aimed to compare changes in cavernosal tissues in rats with antiandrogen treatment and orchiectomy. A total of 42 Wistar albino rats were divided into four groups. Group I, control group, Group II, LH-RH was given for 1 month, Group III-LH-RH + Bicalutamide was given for 1 month, and Group IV was def...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13567

    authors: Firat F,Erdemir F,Günaydın B,Parlaktas BS,Markoç F,Yaşar A

    更新日期:2020-06-01 00:00:00

  • Ameliorative effects of curcumin against acute cadmium toxicity on male reproductive system in rats.

    abstract::The aim of the present study was to investigate the ameliorative effect of curcumin (CMN) against acute cadmium chloride (CdCl(2)) toxicity on male reproductive system in rats. CdCl(2) is known to be a heavy metal and potential environmental pollutant. For this purpose, 28 rats were equally divided into four groups; t...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.2012.01273.x

    authors: Oguzturk H,Ciftci O,Aydin M,Timurkaan N,Beytur A,Yilmaz F

    更新日期:2012-08-01 00:00:00

  • Androgen deficiency impairs erectile function in rats through promotion of corporal fibrosis.

    abstract::The aim of this study was to investigate the underlying mechanism of androgen deficiency inducing corporal fibrosis, thereby causing erectile dysfunction (ED). Forty 12-week-old healthy male rats were divided randomly into four groups: normal control group (Control); castration group (Castration); the other 20 rats we...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.12797

    authors: Cui K,Li R,Chen R,Li M,Wang T,Yang J,Chen Z,Wang S,Liu J,Rao K

    更新日期:2018-02-01 00:00:00

  • Adverse effects of leptin on histone-to-protamine transition during spermatogenesis are prevented by melatonin in Sprague-Dawley rats.

    abstract::This study examines the effect of melatonin on leptin-induced changes in transition of histone to protamine in adult rats during spermatogenesis. Twelve-week-old Sprague-Dawley rats were randomised into control, leptin-, leptin-melatonin-10-, leptin-melatonin-20- and melatonin-10-treated groups with six rats per group...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.12814

    authors: Almabhouh FA,Singh HJ

    更新日期:2018-02-01 00:00:00

  • The value of epididymal protease inhibitor in differential diagnosis between obstructive azoospermia and non-obstructive azoospermia.

    abstract::There are no efficient and noninvasive clinical tests to distinguish between obstructive azoospermia (OA) and non-obstructive azoospermia (NOA). Epididymal protease inhibitor (Eppin) protein is secreted specifically by testes and epididymides in male reproductive system. It does not exist in seminal plasma of patients...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.2011.01085.x

    authors: Liu B,Su S,Wang P,Niu X,Yang X,Zhang W,Wang Z,Wang X

    更新日期:2011-10-01 00:00:00

  • Association between seminal plasma zinc level and asthenozoospermia: a meta-analysis study.

    abstract::Zinc is proposed to have an important role in the morphology, viability and motility of spermatozoa. There are inconsistent reports on the association between seminal plasma zinc concentration and male infertility. For this purpose, papers reporting the level of seminal zinc among asthenozoospermic groups were selecte...

    journal_title:Andrologia

    pub_type: 杂志文章,meta分析

    doi:10.1111/and.12494

    authors: Taravati A,Tohidi F

    更新日期:2016-08-01 00:00:00

  • Assessment of the effect of prolonged forced swimming on CD-1 mice sperm morphology with and without antioxidant supplementation.

    abstract::As physical exercise has been shown to negatively affect sperm morphology, this study was undertaken to assess the effect of a 3-min forced swimming protocol during 50 days, with and without administration of antioxidants [N-acetylcysteine (NAC) and trans-resveratrol], on sperm morphology in CD-1 mice. Forty-four 13-w...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.12443

    authors: Rodriguez I,Diaz A,Vaamonde D

    更新日期:2016-04-01 00:00:00

  • Germ cell apoptosis induced by experimental cryptorchidism is mediated by molecular pathways in mouse testis.

    abstract::The aim of the study was to characterise the alterations in expression of some apoptosis regulators in unilaterally and bilaterally heat-treated mouse testes at different time intervals to 42 days after surgery. Cryptorchidism was induced in immature mice by returning the testis to the abdominal cavity via a surgical ...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.2009.00947.x

    authors: Absalan F,Movahedin M,Mowla SJ

    更新日期:2010-02-01 00:00:00

  • Changes in sexual performance and biochemical characterisation of functional neural regions: A study in serotonin transporter knockout male rats.

    abstract::To explore the correlation between SERT expression and sexual activities and seek the possible mechanism of SERT in regulating ejaculations, we analysed the sexual activities and biochemical characteristics of five measured neural regions in three rat genotypes (SERT-/- , SERT+/- and SERT+/+ ). The results showed the ...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13291

    authors: Geng H,Peng D,Huang Y,Tang D,Gao J,Zhang Y,Zhang X

    更新日期:2019-08-01 00:00:00

  • Studies on the phytomodulatory potential of fenugreek (Trigonella foenum-graecum) on bisphenol-A induced testicular damage in mice.

    abstract::Bisphenol A (BPA), an organic synthetic compound and endocrine disruptor, which majorly cause deleterious effects on male reproductory system. Fenugreek (Trigonella foenum-graecum), associated with Leguminosae family is used as a herbal medicine with potent antioxidant properties. The present study was aimed to scruti...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13492

    authors: Kaur S,Sadwal S

    更新日期:2020-03-01 00:00:00

  • Recurrent painful unilateral gynaecomastia-interactions between hyperthyroidism and hypogonadism.

    abstract::We report an unusual case of recurrent, painful, unilateral gynaecomastia (GM) in an elderly male with relapsing Graves' hyperthyroidism and co-existing primary hypogonadism. This patient presented to the Breast Clinic with a 4-month history of painful, right GM. Malignancy was excluded but T3 was noted to be raised a...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.2006.00681.x

    authors: Jayapaul M,Williams MR,Davies DP,Large DM

    更新日期:2006-02-01 00:00:00

  • CAG repeat length in androgen receptor gene and male infertility in Egyptian patients.

    abstract::The CAG repeat and its association with infertility has been debatable. Therefore, this study was planned to assess the distribution of CAG repeat expansion in Egyptian patients and to investigate its association with male infertility. Forty-five infertile men were eligible for the study in addition to 20 aged-matched...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.2010.01100.x

    authors: Mosaad YM,Shahin D,Elkholy AA,Mosbah A,Badawy W

    更新日期:2012-02-01 00:00:00

  • Expression of RXFP2 receptor on human spermatozoa and the anti-apoptotic and antioxidant effects of insulin-like factor 3.

    abstract::Insulin-like factor 3 (INSL3) has an important role in the human reproductive system; however, its detailed function is still mysterious. We aimed to investigate the possibility of expression of RXFP2 receptor on human spermatozoa and to determine the anti-apoptotic and antioxidant mechanism derived the binding of INS...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13715

    authors: Shokri S,Tavalaee M,Ebrahimi SM,Ziaeipour S,Nasr-Esfahani MH,Nejatbakhsh R

    更新日期:2020-10-01 00:00:00

  • Relationship between penile erection and the ratio of estradiol to testosterone: A retrospective study.

    abstract::Previous studies have found that the ratio of estradiol to testosterone (E2/T ratio) has a negative effect on sexual function, but the relationship between the E2/T ratio and erection of the penis is not clarified. We conducted a retrospective study of 183 patients with erectile dysfunction and 52 healthy men to inves...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13701

    authors: Pan D,Xu ZH,Gao Q,Li M,Guan Y,Zhao ST

    更新日期:2020-10-01 00:00:00

  • Low testicular zinc level, p53 expression and impairment of Sertoli cell phagocytosis of residual bodies in rat subjected to psychological stress.

    abstract::Psychological stress is a known aetiology of infertility. However, the mechanisms translating it to reproductive dysfunction are not fully elucidated. Three experiments were performed on Wistar rats were designed to evaluate Sertoli cell function under stress. In Experiment I, rats were randomised into three groups: s...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13958

    authors: Medubi LJ,Akinola OB,Oyewopo AO

    更新日期:2021-01-19 00:00:00

  • Intra-uterine insemination with prepared sperm vs. unprepared first split ejaculates. A randomized study.

    abstract::In this randomized prospective study, we determined the conception rate following intra-uterine insemination with washed and prepared sperm, or with the first portion of a split ejaculate, in couples with longstanding male (n = 27, 70 treatment cycles) or cervical infertility (n = 14, 29 treatment cycles). Folliculoge...

    journal_title:Andrologia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1439-0272.1992.tb02626.x

    authors: Goldenberg M,Rabinovici J,Bider D,Lunenfeld B,Blankstein J,Weissenberg R

    更新日期:1992-05-01 00:00:00

  • Role of the hypothalamic opioidergic system in the control of gonadotropin secretion in elderly men.

    abstract::The role of opioidergic system in controlling gonadotropin secretion in elderly men still remains uncertain. In the present study, we attempted to examine the opioidergic inhibitory tone imposed on GnRH release mechanism in elderly men by monitoring the plasma gonadotropin response to the opiate receptor antagonist na...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1994.tb00752.x

    authors: Mikuma N,Kumamoto Y,Maruta H,Nitta T

    更新日期:1994-01-01 00:00:00