Deregulation of Aurora kinase gene expression in human testicular germ cell tumours.

Abstract:

:The Aurora kinases regulate chromosome segregation and cytokinesis, and alterations in their expression associate with cell malignant transformation. In this study, we demonstrated by qRT-PCR analysis of 14 seminomas that Aurora-A mRNA was, with respect to control tissues, augmented in five of 14 tumour tissues by 2.17 +/- 0.30 fold (P < 0.05) and reduced in 9 to 0.38 +/- 0.10 (P < 0.01). Aurora-B mRNA was increased in 11 tumour tissues by 4.33 +/- 0.82 fold (P < 0.01) and reduced in 3 to 0.41 +/- 0.11 fold. Aurora-C mRNA was reduced to 0.20 +/- 0.32 fold (P < 0.01) in 13 seminomas and up-regulated in one case. Western blot experiments, performed on protein extracts of nine seminomas and six normal testes, showed an up-regulation of Aurora-B protein by 10.14 +/- 3.51 fold (P < 0.05), while Aurora-A protein was found increased in four seminomas by 2.16 +/- 0.43 (P < 0.05), unchanged in three and reduced in two tumour tissues. Aurora-C protein was increased by 9.2 +/- 2.90 fold (P < 0.05), suggesting that post-transcriptional mechanisms modulate its expression. In conclusion, we demonstrated that expression of Aurora kinases is deregulated in seminomas, suggesting that they may play a role in the progression of testicular cancers.

journal_name

Andrologia

journal_title

Andrologia

authors

Baldini E,Arlot-Bonnemains Y,Mottolese M,Sentinelli S,Antoniani B,Sorrenti S,Salducci M,Comini E,Ulisse S,D'Armiento M

doi

10.1111/j.1439-0272.2009.00987.x

subject

Has Abstract

pub_date

2010-08-01 00:00:00

pages

260-7

issue

4

eissn

0303-4569

issn

1439-0272

pii

AND987

journal_volume

42

pub_type

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