Germ cell apoptosis induced by experimental cryptorchidism is mediated by molecular pathways in mouse testis.


:The aim of the study was to characterise the alterations in expression of some apoptosis regulators in unilaterally and bilaterally heat-treated mouse testes at different time intervals to 42 days after surgery. Cryptorchidism was induced in immature mice by returning the testis to the abdominal cavity via a surgical procedure. Transcript levels of Bax, Bcl-2 proper, p53 and survivin mRNA and protein were determined in normal and cryptorchid testes using reverse transcription polymerase chain reaction (RT-PCR) and immunohistochemistry. RT-PCR data verified the elevation of p53 expression and decrease of Bax and Bcl-2 proper mRNA in the cryptorchid testis in a time-dependent manner. The expression of survivin 140 and 40 variants strongly decreased in the bilateral groups compared with unilateral and control groups. These changes were significantly different in the bilateral groups in comparison with the unilateral groups. Immunohistochemistry data showed that the intensity of p53 and Bax expression mainly increased in the remainder cells in the cryptorchid testis and the rates of Bcl-2 proper and survivin expression decreased mainly in the bilateral groups. These observations suggest that multiple molecular pathways participate in the germ cell apoptosis induced by cryptorchidism.






Absalan F,Movahedin M,Mowla SJ




Has Abstract


2010-02-01 00:00:00














  • Altered gene expression profiles of testicular tissues from azoospermic patients with maturation arrest.

    abstract::Maturation arrest is a common cause of male infertility which has caused worldwide concern, and its pathophysiological process remains further elucidation. Our study aimed to identify genetic characteristics of maturation arrest by comparing gene expression between maturation arrest and normal samples using microarray...


    pub_type: 杂志文章


    authors: Fang Y,Liu D,Yang Y,Zhang H,Wu H,Jiang H,Zhao L,Zhang Z

    更新日期:2020-12-01 00:00:00

  • Thyroid response to dexamethasone: a study on normal controls and patients with psychogenic sexual dysfunction.

    abstract::Pre- and postdexamethasone triiodothyronine (T3), thyroxine (T4), and TSH levels of thirteen patients with psychogenic sexual dysfunction and thirteen controls were studied. Patients showed lowered T4 levels in comparison with the control group whereas T3 and TSH levels did not differ significantly. Dexamethasone had ...


    pub_type: 杂志文章


    authors: Noder M,Rupprecht R,Rupprecht M,Rupprecht C,Hornstein OP

    更新日期:1990-01-01 00:00:00

  • Low testicular zinc level, p53 expression and impairment of Sertoli cell phagocytosis of residual bodies in rat subjected to psychological stress.

    abstract::Psychological stress is a known aetiology of infertility. However, the mechanisms translating it to reproductive dysfunction are not fully elucidated. Three experiments were performed on Wistar rats were designed to evaluate Sertoli cell function under stress. In Experiment I, rats were randomised into three groups: s...


    pub_type: 杂志文章


    authors: Medubi LJ,Akinola OB,Oyewopo AO

    更新日期:2021-01-19 00:00:00

  • [Morphologic studies of spermatozoa in disorders of motility].

    abstract::On the basis of microscopical examination and further differentiation by special stain techniques, a new classification of defects of midpieces and tails of spermatozoa will be presented: First degree disorders i.e. abnormalities of the staining behaviour and minor structural defects, second degree disorders revealing...


    pub_type: 杂志文章


    authors: Haidl G,Hartmann R,Hofmann N

    更新日期:1987-07-01 00:00:00

  • Study of sperm morphologic characteristics in a group of 833 fertile men.

    abstract::For the 13 abnormalities under consideration, the mean percentages were found to be the following: irregular head (15.2), microcephalic (9.8), elongated head (5.9), coiled tail (5.8), bent tail (4.7), thin head (4.6), cytoplasmic remains (3.2), macrocephalic (1.6), short tail (1.1), no tail (0.6), duplicate tail (0.5)...


    pub_type: 杂志文章


    authors: Schwartz D,Mayaux MJ,Guihard-Moscato ML,Spira A,Jouannet P,Czyglik F,David G

    更新日期:1984-09-01 00:00:00

  • Effect of intratesticular administration of anti-corticotropin-releasing factor antiserum (a-CRF) on testicular function in neonatal rats.

    abstract::The possible physiological role of testicular corticotropin-releasing factor (CRF) in the regulation of testicular functions was studied in neonatal rats. Two microlitres of anti-CRF-antiserum (dilution: 1:10 or 1:100) was injected intratesticularly to 5 d-old rats with two testes and to hemicastrates. Five days after...


    pub_type: 杂志文章


    authors: Gerendai I,Nemeskéri A,Csernus V

    更新日期:1993-07-01 00:00:00

  • Sitagliptin protects male albino rats with testicular ischaemia/reperfusion damage: Modulation of VCAM-1 and VEGF-A.

    abstract::Twisting of the spermatic cord is considered a popular problem in the urological field, which may lead to testicular necrosis and male infertility. Sitagliptin, a glucose-lowering agent, proved to have a vindicatory function in myocardial and renal ischaemia/reperfusion (I/R), but its role in testicular I/R has not ye...


    pub_type: 杂志文章


    authors: Abdel-Aziz AM,Naguib Abdel Hafez SM

    更新日期:2020-03-01 00:00:00

  • [Use of the ultrasonic Doppler stethoscope in the diagnosis of varicocele].

    abstract::In cases of varicocele the reverse venous blood flow can be detected by the use of the Doppler-stethoscope in a simple way. Applied to the basic examination of fertility patients this method has proved to be a valuable non-invasive screening in the evaluation of varicoceles including cases with minor clinical symptoms...


    pub_type: 杂志文章


    authors: Ebert L,Bedbur M,Hofmann N

    更新日期:1980-09-01 00:00:00

  • In vitro antioxidant effect of curcumin on human sperm quality in leucocytospermia.

    abstract::Decreased sperm quality was caused by oxidative stress in semen from patients with leucocytospermia. Curcumin is a traditional Chinese herbal monomer extracted from Zingiberaceae turmeric and zedoary turmeric and has antioxidative and anti-inflammatory effects. This study aimed to investigate the effects and specific ...


    pub_type: 杂志文章


    authors: Zhang L,Diao RY,Duan YG,Yi TH,Cai ZM

    更新日期:2017-12-01 00:00:00

  • Is there a significance of histamine in the control of the human male sexual response?

    abstract::Although histamine has been suggested to be involved in the control of male sexual function, including the induction of penile erection, its role in the human corpus cavernosum penis is still poorly understood. The aim of our study was to evaluate the course of histamine plasma levels through different stages of sexua...


    pub_type: 杂志文章


    authors: Uckert S,Wilken M,Stief C,Trottmann M,Kuczyk M,Becker A

    更新日期:2012-05-01 00:00:00

  • Does male factor infertility impact on self-esteem and sexual relationship?

    abstract::Nonsomatic factors play a significant role in erectile dysfunction. We assessed the impact on men suffering from male factor infertility by employing the validated Self-Esteem and Relationship questionnaire (SEAR) and compared the scores with controls. Men with primary infertility were asked to fill SEAR questionnaire...


    pub_type: 杂志文章


    authors: Jamil S,Shoaib M,Aziz W,Ather MH

    更新日期:2020-03-01 00:00:00

  • [Separation of motile spermatozoa by "Separon" as measured by a videomicrography computer system].

    abstract::By means of a recently developed apparatus ("Separon") motile spermatozoa were concentrated in a small volume of culture medium (0,3 ml). Sperm concentration, progressive motility and mean velocity of 60 ejaculates were determined by a computerized videomicrography system. After "Separon" sperm concentration was reduc...


    pub_type: 杂志文章


    authors: Wölbling RH,Pemper B,Möslein S,Milbradt R,Taubert HD

    更新日期:1988-01-01 00:00:00

  • The effects of vasectomy on viscosity, pH and volume of semen in man.

    abstract::The effects of vasectomy on seminal viscosity, volume and pH have been investigated in freshly emitted semen of 21 healthy men before operation and three months later. Viscosity and the pH range were decreased significantly, but the decrease of the seminal volume was not significant. Reasons of changes have been discu...


    pub_type: 杂志文章


    authors: Nikkanen V

    更新日期:1979-03-01 00:00:00

  • Role of the hypothalamic opioidergic system in the control of gonadotropin secretion in elderly men.

    abstract::The role of opioidergic system in controlling gonadotropin secretion in elderly men still remains uncertain. In the present study, we attempted to examine the opioidergic inhibitory tone imposed on GnRH release mechanism in elderly men by monitoring the plasma gonadotropin response to the opiate receptor antagonist na...


    pub_type: 杂志文章


    authors: Mikuma N,Kumamoto Y,Maruta H,Nitta T

    更新日期:1994-01-01 00:00:00

  • The treatment of male subfertility with kallikrein.

    abstract::In a controlled double blind trial the effectiveness and tolerability of Kallikrein in patients suffering from astheno-oligozoospermia was examined in comparison to placebo. 30 patients with astheno-oligozoospermia of idiopathic origin entered the study; they were subdivided into two homogeneous groups of 15 patients ...


    pub_type: 临床试验,杂志文章


    authors: Izzo PL,Canale D,Bianchi B,Meschini P,Esposito G,Menchini Fabris GF,Fasani R,Ohnmeiss H

    更新日期:1984-03-01 00:00:00

  • Semen quality in adult male survivors 5 years after the 2008 Wenchuan earthquake.

    abstract::The influence of the Wenchuan earthquake on semen quality of adult male survivors is unclear. We investigated the semen quality included 673 male survivors from the worse-affected counties in the earthquake between Aug 2008 and July 2013. Semen parameters including pH, volume, concentration, motility and morphology we...


    pub_type: 杂志文章


    authors: Chen XM,Chen SM,Yue HX,Lin L,Wu YB,Liu B,Jiang M,Ma YX

    更新日期:2016-12-01 00:00:00

  • Contribution of epididymal factors to sperm maturation and storage.

    abstract::In fertile men, the majority of epididymal spermatozoa acquire the potential to fertilize (assessed with sperm function assays) on passage into the corpus and cauda regions of the epididymis. Although secretions of the epididymal epithelium are clearly important for sperm maturation and survival, their role in this pr...


    pub_type: 杂志文章,评审


    authors: Moore HD

    更新日期:1998-08-01 00:00:00

  • A quantitative morphological study of age-related changes in the donkey testis in the period between puberty and senium.

    abstract::The testis of the donkey was used as a model to study age-related changes in the period between puberty and senium. From the age of 1.5 years to the middle of sexual maturity (5 to 6 years) a number of histophysiological features, all indicative of the spermatogenetic efficiency, increase continuously. Then without a ...


    pub_type: 杂志文章


    authors: Nipken C,Wrobel KH

    更新日期:1997-05-01 00:00:00

  • The effects of hesperidin on colistin-induced reproductive damage, autophagy, and apoptosis by reducing oxidative stress.

    abstract::This study has been conducted to investigate the effect of hesperidin on colistin-induced reproductive damage in male rats. Twenty-four adult male Sprague Dawley rats were used as animal material. They were divided into four groups: control group, received physiological saline for 7 days by oral gavage; hesperidin gro...


    pub_type: 杂志文章


    authors: Aksu EH,Kandemir FM,Küçükler S

    更新日期:2020-12-01 00:00:00

  • Medium containing different concentrations of catalase as a strategy for optimising sperm parameters and chromatin in normospermic persons.

    abstract::The aim of this study was to comprise the effect of catalase on sperm parameters and chromatin in normospermic persons. Semen samples were obtained from fertile men. A certain amount of different concentrations of catalase (0.1, 1, 10, 50, 100, 150 and 200 was added to each vial containing semen. Control group ...


    pub_type: 杂志文章


    authors: Mohammadzadeh M,Ramazani V,Khalili MA,Hamishekar H,Dehghan Marvast L,Talebi AR,Zare-Zardini H,Ghasemi S

    更新日期:2019-05-01 00:00:00

  • Rat sperm immobilisation effects of a protein from Ricinus communis (Linn.): an in vitro comparative study with nonoxynol-9.

    abstract::Previous study conducted in our department showed that 50% ethanolic extract of the root of Ricinus communis possess reversible antifertility effect and a 62-kDa protein (Rp) from this extract is responsible for the antifertility effects. In this study, we compared the spermicidal effect of this Rp with nonoxynol-9 (N...


    pub_type: 杂志文章


    authors: Nithya RS,Anuja MM,Rajamanickam C,Indira M

    更新日期:2012-12-01 00:00:00

  • Purification and characterization of angiotensin converting enzyme-II from bovine seminal plasma.

    abstract::Angiotensin converting enzyme (EC from bovine seminal plasma was shown to exist in two distinct forms. A lower molecular weight form of the enzyme having higher activity was purified to homogeneity. Final recovery of the enzyme was 18.37%. The apparent molecular weight of the enzyme was estimated to be 1.99 ...


    pub_type: 杂志文章


    authors: Sharma M,Singh US

    更新日期:1991-07-01 00:00:00

  • Testosterone replacement therapy improves health-related quality of life for patients with late-onset hypogonadism: a meta-analysis of randomized controlled trials.

    abstract::Although testosterone replacement therapy can restore serum testosterone concentrations to normal level in late-onset hypogonadism patients, whether it can improve patients' quality of life remains uncertain. Therefore, we perform a meta-analysis of randomized controlled trials on this issue. Five randomized controlle...


    pub_type: 杂志文章,meta分析


    authors: Nian Y,Ding M,Hu S,He H,Cheng S,Yi L,Li Y,Wang Y

    更新日期:2017-05-01 00:00:00

  • Recovery from azoospermia caused by a testicular injury: a case report.

    abstract::Some cases of testicular trauma cause infertility especially when the injured testes are not removed. However, only a few long-term follow-up studies investigating endocrinological and semen parameters in patients who had testicular trauma have been conducted. Herein, we report an interesting case of a patient who spo...


    pub_type: 杂志文章


    authors: Hagiuda J,Ishikawa H,Hanawa Y,Marumo K

    更新日期:2014-05-01 00:00:00

  • Prevalence of low serum cobalamin in infertile couples.

    abstract::A high prevalence of low levels of cobalamin had been found in a survey of multi-ethnic normal individuals in Israel. The purpose of this study was to investigate the incidence of cobalamin deficiency among Israeli couples suffering from infertility. All couples seen at the in vitro fertilization clinic at an urban ho...


    pub_type: 杂志文章


    authors: Pront R,Margalioth EJ,Green R,Eldar-Geva T,Maimoni Z,Zimran A,Elstein D

    更新日期:2009-02-01 00:00:00

  • Mast cells in testicular biopsies of infertile men with 'mixed atrophy' of seminiferous tubules.

    abstract::Mast cells in the bilateral testicular biopsies of 30 patients with a 'mixed atrophy' of seminiferous tubules were analysed. Seven biopsies from vasectomized patients served as controls. With regard to their characteristic location within testicular tissue, two groups of mast cells could be distinguished, in both cont...


    pub_type: 杂志文章


    authors: Jezek D,Banek L,Hittmair A,Pezerović-Panijan R,Goluza T,Schulze W

    更新日期:1999-07-01 00:00:00

  • Effects of a DNA-specific fluorochrome, Hoechst 33258, on mouse sperm motility and fertilizing capacity.

    abstract::DNA specific fluorochrome (Hoechst 33342 and 33258) as non-toxic stains, have been widely used to measure cell density and proliferation, detect sperm-egg fusion, and observe the development of pre-implantation embryos. It has been reported that Hoechst 33342 at a concentration of 10 micrograms ml-1 had significant in...


    pub_type: 杂志文章


    authors: Yelian FD,Dukelow WR

    更新日期:1992-05-01 00:00:00

  • Glutathione S-transferase Mu-1 gene polymorphism in Egyptian patients with idiopathic male infertility.

    abstract::The aim of this study was to examine whether an association exists between glutathione S-transferase Mu-1 (GSTM1) gene polymorphism and idiopathic male infertility. Sixty men with primary idiopathic infertility and 60 fertile men, serving as controls, were recruited for the study. The polymorphism was analysed using p...


    pub_type: 杂志文章


    authors: Roshdy OH,Hussein TM,Zakaria NH,Sabry AA

    更新日期:2015-06-01 00:00:00

  • Microvasculature of the human testis in correlation to Leydig cells and seminiferous tubules.

    abstract::The microvasculature of the human testis is closely related to the Leydig cells and the seminiferous tubules. Semi-thin sections of testicular tissue serve as a basis for the computer-aided 3-D reconstruction of the microvasculature, the seminiferous tubules and the Leydig cells. After vascular perfusion with glutaral...


    pub_type: 杂志文章


    authors: Ergün S,Stingl J,Holstein AF

    更新日期:1994-09-01 00:00:00

  • [Fertility of workers exposed to herbicides and pesticides].

    abstract::Twenty-one workmen exposed to herbicide as organic mercury compounds and to pesticide as halogenic hydrocarbon has been investigated concerning their fertility. If the concentrations of organic mercury compounds increase in the air of the place of employment then the levels of this heavy metal are also higher in the u...


    pub_type: 杂志文章


    authors: Donat H,Matthies J,Schwarz I

    更新日期:1990-09-01 00:00:00