Glutathione S-transferase Mu-1 gene polymorphism in Egyptian patients with idiopathic male infertility.

Abstract:

:The aim of this study was to examine whether an association exists between glutathione S-transferase Mu-1 (GSTM1) gene polymorphism and idiopathic male infertility. Sixty men with primary idiopathic infertility and 60 fertile men, serving as controls, were recruited for the study. The polymorphism was analysed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. The frequency of GSTM1 null genotype was observed to be higher in infertile men 40% in comparison with 33.3% in the fertile men, but this difference was not statistically significant. There was statistically significant difference between cases and controls as regards GSTM1 genotype distribution ((MC) P = 0.006*) in GSTM1-positive men. Patients with the GSTM1 null genotype had significantly lower sperm concentrations and total sperm count when compared with patients with GSTM1-positive genotype. In the control group, men with GSTM1 null genotype had significantly lower sperm concentrations but not total sperm count when compared with men with GSTM1-positive genotype. The results of this study suggest a possible negative effect of GSTM1 null genotype on the spermatogenic potential of the testis.

journal_name

Andrologia

journal_title

Andrologia

authors

Roshdy OH,Hussein TM,Zakaria NH,Sabry AA

doi

10.1111/and.12306

subject

Has Abstract

pub_date

2015-06-01 00:00:00

pages

587-93

issue

5

eissn

0303-4569

issn

1439-0272

journal_volume

47

pub_type

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