Endocrine and spermatological characteristics of 135 patients with bilateral megalotestis.

Abstract:

:Little is known about the biological and clinical significance of bilaterally enlarged testes (bilateral megalotestes or macroorchidism). We have investigated clinical, endocrine and spermatological characteristics of 135 andrological patients with a testicular volume of more than 25 ml bilaterally. 135 patients with normal testicular volumes served as controls. Subjects with bilateral megalotestis had higher sperm counts and better sperm morphology and motility than the controls. Levels of LH, FSH, prolactin, testosterone and estradiol were lower in the megalotestis group. This was statistically significant for LH and FSH. No testicular tumours were diagnosed in either group. We conclude that in most andrological patients with bilateral megalotestes fertility parameters are excellent despite the unusually low hormone levels found in a significant minority. No specific pathology underlying the large gonadal volume could be identified.

journal_name

Andrologia

journal_title

Andrologia

authors

Meschede D,Behre HM,Nieschlag E

doi

10.1111/j.1439-0272.1995.tb01094.x

subject

Has Abstract

pub_date

1995-07-01 00:00:00

pages

207-12

issue

4

eissn

0303-4569

issn

1439-0272

journal_volume

27

pub_type

杂志文章
  • Clinical and cytogenomic studies in a case of infertility associated with a nonmosaic dicentric Y chromosome.

    abstract::In this study, a short stature male with infertility is reported. Semen analysis and serum concentrations of FSH, LH, T and PRL were estimated. Chromosome analysis was performed on lymphocytes obtained from both the male and his parents. Cytogenomic studies were performed by fluorescent in situ hybridisation and the C...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.12278

    authors: Cui YX,Wang WP,Li TF,Li WW,Wu QY,Li N,Zhang C,Yao Q,Hu YA,Xia XY

    更新日期:2015-05-01 00:00:00

  • Tubular hyalinization in human testis.

    abstract::Tubular hyalinization was studied both light and electron microscopically in 22 cases. 8 of them were found in undescended testes and 5 cases represented possible intermediary forms with only partial hyalinization of the tubules. In these testes spermatogenic arrest, hypospermatogenesis, only Sertoli cells and areas w...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1986.tb01746.x

    authors: Söderström KO

    更新日期:1986-01-01 00:00:00

  • Relationship of interleukin-6 with semen characteristics and oxidative stress in vasectomy reversal patients.

    abstract::This prospective study was performed to evaluate the relationship between interleukin-6 (IL-6), oxidative stress and sperm function following vasectomy reversal. We included 22 patients who underwent vasectomy reversal and 15 healthy sperm donors (controls) with normal sperm morphology criteria. Levels of IL-6 in the ...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.2005.00668.x

    authors: Nandipati KC,Pasqualotto FF,Thomas AJ Jr,Agarwal A

    更新日期:2005-08-01 00:00:00

  • Men born in the region of Leipzig (Saxony, Germany) between 1960 and 1970 showed a significantly decreased sperm count (examination of 3432 individuals).

    abstract::The routine spermiogram parameters of 3432 patients born between 1952 and 1971 in the region of Leipzig were determined between January 1975 and March 2000. The patient group aged 24-35 years was characterized by low mobility and relocation living in the main centre of chemical industry with enormous environmental pol...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1046/j.0303-4569.2003.00590.x

    authors: Paasch U,Thieme C,Glander HJ

    更新日期:2003-12-01 00:00:00

  • Infertility and HLA antigen - male infertility and infertile couples. - Correlation between HLA antigen and infertility.

    abstract::On the basis of the concept that immunogenetic factors play a role in the incidence of unexplained male infertility, the so-called idiopathic infertility, HLA antigen analyses were performed for (1) azoospermia cases among the infertile males diagnosed by testicular biopsies as having germ cell aplasia and (2) unexpla...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1980.tb00638.x

    authors: Kamidono S,Matsumoto O,Ishigami J,Nakao Y,Tsuji K

    更新日期:1980-07-01 00:00:00

  • Decreased polyunsaturated and increased saturated fatty acid concentration in spermatozoa from asthenozoospermic males as compared with normozoospermic males.

    abstract::The lipid composition of the sperm membrane has been shown to exert a significant effect upon the functional quality of spermatozoa. We have studied fatty acid composition of the phospholipids in spermatozoa in asthenozoospermic and normozoospermic men and determined the ratio of polyunsaturated fatty acids (PUFAs) to...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.2006.00735.x

    authors: Tavilani H,Doosti M,Abdi K,Vaisiraygani A,Joshaghani HR

    更新日期:2006-10-01 00:00:00

  • Glutathione S-transferase Mu-1 gene polymorphism in Egyptian patients with idiopathic male infertility.

    abstract::The aim of this study was to examine whether an association exists between glutathione S-transferase Mu-1 (GSTM1) gene polymorphism and idiopathic male infertility. Sixty men with primary idiopathic infertility and 60 fertile men, serving as controls, were recruited for the study. The polymorphism was analysed using p...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.12306

    authors: Roshdy OH,Hussein TM,Zakaria NH,Sabry AA

    更新日期:2015-06-01 00:00:00

  • Anatomical endoscopic enucleation of the prostate: The next gold standard? Yes!

    abstract::Anatomical endoscopic enucleation of the prostate (AEEP) differs from other surgical techniques for benign prostatic obstruction (BPO) in that it removes the entire benign prostatic hyperplasia (BPH) component of the prostate. We summarise the main advantages of AEEP compared to other surgical techniques for BPO. Thes...

    journal_title:Andrologia

    pub_type: 杂志文章,评审

    doi:10.1111/and.13643

    authors: Aho T,Armitage J,Kastner C

    更新日期:2020-09-01 00:00:00

  • In vivo effects of Eurycoma longifolia Jack (Tongkat Ali) extract on reproductive functions in the rat.

    abstract::An aqueous extract of Eurycoma longifolia (Tongkat Ali; TA) roots is traditionally used to enhance male sexuality. Because previous studies are limited to only few sperm parameters or testosterone concentration, this study investigated the in vivo effects of TA on body and organ weight as well as functional sperm para...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.12082

    authors: Solomon MC,Erasmus N,Henkel RR

    更新日期:2014-05-01 00:00:00

  • Spermagglutinating antibodies: a comparison of three different techniques.

    abstract::In 136 patients tests were performed to demonstrate circulating spermagglutinating antibodies. In patients with "unexplained" infertility (15 cases) antibodies were demonstrated in six (40%) whereas in patients where another cause for infertility was present (101 cases) additional positive spermagglutinating antibodie...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1980.tb00570.x

    authors: Franken DR,Slabber CF

    更新日期:1980-01-01 00:00:00

  • Reliable single sperm cryopreservation in Cell Sleepers for azoospermia management.

    abstract::Conventional sperm freezing methods perform best when freezing sperm samples containing at least hundreds of spermatozoa. In this severe male factor infertility case series, we examined the reproductive outcomes in 12 intracytoplasmic sperm injection cases where spermatozoa used were frozen in Cell Sleepers. Cell Slee...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.12434

    authors: Coetzee K,Ozgur K,Berkkanoglu M,Bulut H,Isikli A

    更新日期:2016-03-01 00:00:00

  • Testosterone, FSH and LH in human spermatic and cubital venous plasma in varicocele patients.

    abstract::The plasma level of testosterone, FSH and LH were determined simultaneously in spermatic and cubital veins in 12 patients with varicocele. The testosterone levels in spermatic veins were 13.4 +/- 5.3 times higher than in cubital veins. FSH and LH levels were higher in cubital than in spermatic vein. No correlation was...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1985.tb01018.x

    authors: Bablok L,Janczewski Z,Czaplicki M

    更新日期:1985-07-01 00:00:00

  • Studies on the male antifertility agent gossypol acetic acid. VII. Effect of motility stimulated factors on the revival of human spermatozoal motility after gossypol treatment in vitro.

    abstract::Human spermatozoa were incubated with gossypol acetic acid (100 micrograms/1 X 10(6) spermatozoa/ml) at 37 degrees C for 30 min. The drug treatment inhibited the spermatozoal motility significantly. Washing of the spermatozoa, after gossypol treatment, did not effect their motility. A partial revival in the motility o...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1986.tb01797.x

    authors: Kalla NR,Gadru N,Foo TW

    更新日期:1986-07-01 00:00:00

  • Recovery from azoospermia caused by a testicular injury: a case report.

    abstract::Some cases of testicular trauma cause infertility especially when the injured testes are not removed. However, only a few long-term follow-up studies investigating endocrinological and semen parameters in patients who had testicular trauma have been conducted. Herein, we report an interesting case of a patient who spo...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.12089

    authors: Hagiuda J,Ishikawa H,Hanawa Y,Marumo K

    更新日期:2014-05-01 00:00:00

  • Black soot exposure induced hypothalamic and testicular oxidative stress and apoptosis in male rats.

    abstract::Air pollution constitutes the largest cause of environmental risks today. At present, no scientific publication linking environmental black soot and derangement in the hypothalamus and testis of rats exists. This study investigated the effect of black soot exposure on hypothalamic and testicular functions of male rats...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13866

    authors: Onyeso G,Bohr EL,Nkpaa KW,Amadi PN,Ugwu AC

    更新日期:2020-12-01 00:00:00

  • Chronic immobilization-induced stress increases plasma testosterone and delays testicular maturation in pubertal rats.

    abstract::We investigated whether chronic stress, applied from prepuberty to early puberty, interferes with the spermatogenic and androgenic testicular functions. Male pubertal rats (40 days old) were immobilized 6 h per day for 15 days. Plasma concentrations of corticosterone, prolactin and testosterone were significantly augm...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:

    authors: Almeida SA,Petenusci SO,Franci JA,Rosa e Silva AA,Carvalho TL

    更新日期:2000-01-01 00:00:00

  • Retracted: Aetiology and clinical profile of children with 46, XY differences of sex development at an Indian referral centre.

    abstract::Retraction: 'Aetiology and clinical profile of children with 46, XY differences of sex development at an Indian referral centre' by Vasundhera Chauhan, Rima Dada, Vandana Jain The above article, published online on 8 August 2016 in Wiley Online Library (http://wileyonlinelibrary.com), has been retracted by agreement b...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.12663

    authors: Chauhan V,Dada R,Jain V

    更新日期:2017-11-01 00:00:00

  • Contribution of epididymal factors to sperm maturation and storage.

    abstract::In fertile men, the majority of epididymal spermatozoa acquire the potential to fertilize (assessed with sperm function assays) on passage into the corpus and cauda regions of the epididymis. Although secretions of the epididymal epithelium are clearly important for sperm maturation and survival, their role in this pr...

    journal_title:Andrologia

    pub_type: 杂志文章,评审

    doi:10.1111/j.1439-0272.1998.tb01165.x

    authors: Moore HD

    更新日期:1998-08-01 00:00:00

  • The synthetic androgen mibolerone induces transient suppression of the transformed phenotype in an androgen responsive human prostatic carcinoma cell line.

    abstract::The synthetic androgen mibolerone elicits a set of distinct changes in the behaviour of an androgen responsive human prostatic carcinoma cell line (LNCaP). Inhibition of cell proliferation, induction of morphological change and of a prostate specific mRNA, and inhibition of colony formation in soft agar are induced by...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1990.tb02071.x

    authors: Schulz P,Wolf D,Arbusow V,Bojar H,Klobeck HG,Fittler F

    更新日期:1990-01-01 00:00:00

  • Functional characterisation of a natural androgen receptor missense mutation (N771H) causing human androgen insensitivity syndrome.

    abstract::Androgen insensitivity syndrome (AIS) is an X-linked disorder due to mutations of androgen receptor (AR) gene. Various AR mutations have been identified, and the characterisation of these mutations greatly facilitates our understanding of AR structure-function. In this study, we have analysed an AR missense mutation (...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.2011.01219.x

    authors: Cai J,Cai LQ,Hong Y,Zhu YS

    更新日期:2012-05-01 00:00:00

  • Association between seminal plasma zinc level and asthenozoospermia: a meta-analysis study.

    abstract::Zinc is proposed to have an important role in the morphology, viability and motility of spermatozoa. There are inconsistent reports on the association between seminal plasma zinc concentration and male infertility. For this purpose, papers reporting the level of seminal zinc among asthenozoospermic groups were selecte...

    journal_title:Andrologia

    pub_type: 杂志文章,meta分析

    doi:10.1111/and.12494

    authors: Taravati A,Tohidi F

    更新日期:2016-08-01 00:00:00

  • The relationship between methylenetetrahydrofolate reductase c.677TT genotype and oligozoospermia in infertile male patients living in the Trakya region of Turkey.

    abstract::Methylenetetrahydrofolate reductase (MTHFR), the key enzyme of the folate metabolic pathway, has been reported to be five times more active in the testicles compared to other organs in adult mice. The aim of this study was to investigate the relationship between MTHFR c.677C>T and c.1298A>C polymorphisms and infertili...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.12380

    authors: Gurkan H,Tozkır H,Göncü E,Ulusal S,Yazar M

    更新日期:2015-11-01 00:00:00

  • Role of the hypothalamic opioidergic system in the control of gonadotropin secretion in elderly men.

    abstract::The role of opioidergic system in controlling gonadotropin secretion in elderly men still remains uncertain. In the present study, we attempted to examine the opioidergic inhibitory tone imposed on GnRH release mechanism in elderly men by monitoring the plasma gonadotropin response to the opiate receptor antagonist na...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1994.tb00752.x

    authors: Mikuma N,Kumamoto Y,Maruta H,Nitta T

    更新日期:1994-01-01 00:00:00

  • Efficacy and safety of testosterone replacement gel for treating hypogonadism in men: Phase III open-label studies.

    abstract::Efficacy and safety of testosterone gel 2% (TG) were evaluated in two phase 3, open-labelled, single-arm, multicentre studies (000023 and extension study 000077). Hypogonadal men having serum testosterone levels <300 ng/dl at two consecutive measurements were included. Study duration was 9 months (000023: 3 months; 00...

    journal_title:Andrologia

    pub_type: 杂志文章,多中心研究

    doi:10.1111/and.12801

    authors: Belkoff L,Brock G,Carrara D,Neijber A,Ando M,Mitchel J

    更新日期:2018-02-01 00:00:00

  • Update on the impact of Chlamydia trachomatis infection on male fertility.

    abstract::With approximately 90 million cases annually, infection with Chlamydia trachomatis is the most prevalent sexually transmitted bacterial disease in the world. Considering that these infections are often asymptomatic and cause major complications like acute pelvic inflammatory disease, ectopic pregnancy, infertility or ...

    journal_title:Andrologia

    pub_type: 杂志文章,评审

    doi:10.1046/j.0303-4569.2003.00594.x

    authors: Gonzales GF,Muñoz G,Sánchez R,Henkel R,Gallegos-Avila G,Díaz-Gutierrez O,Vigil P,Vásquez F,Kortebani G,Mazzolli A,Bustos-Obregón E

    更新日期:2004-02-01 00:00:00

  • Feeding hydroalcoholic extract powder of Lepidium meyenii (maca) enhances testicular gene expression of 3β-hydroxysteroid dehydrogenase in rats.

    abstract::Although feeding diets containing the extract powder of Lepidium meyenii (maca), a plant growing in Peru's Central Andes, increases serum testosterone concentration associated with enhanced ability of testosterone production by Leydig cells in male rats, changes in testicular steroidogenesis-related factors by the mac...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.12792

    authors: Ohta Y,Kawate N,Inaba T,Morii H,Takahashi K,Tamada H

    更新日期:2017-12-01 00:00:00

  • Leptin exists in tubuli seminiferi and in seminal plasma.

    abstract::Leptin is a 167-amino acid protein that stimulates gonadotrophin-releasing hormone secretion and exerts indirect effects on the gonads via neuropeptide Y, NPY. Recent research has suggested that leptin may also have an effect on testosterone secretion. To investigate the role of leptin in reproduction, leptin in testi...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1046/j.1439-0272.2002.00501.x

    authors: Glander HJ,Lammert A,Paasch U,Glasow A,Kratzsch J

    更新日期:2002-09-01 00:00:00

  • Semen analysis in alcohol dependence syndrome.

    abstract::Analysis of seminal fluid samples from 20 ADS cases is reported for the first time. A significant decrease in the total volume of complete semen sample and sperm concentration was observed. Percentage of morphologically abnormal sperms was higher in samples from ADS cases than controls, though no linear correlation wa...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1985.tb01714.x

    authors: Kucheria K,Saxena R,Mohan D

    更新日期:1985-11-01 00:00:00

  • Purification and properties of gamma-glutamyl transpeptidase from human testis.

    abstract::Gamma-glutamyl transpeptidase was purified to apparent homogeneity from human testis by DEAE cellulose, acetone, precipitation, fractionation by ammonium sulphate, Sephacryl S-200 chromatography, Q-Sepharose chromatography and S-Sepharose chromatography following solubilization of the enzyme by Triton X-100. The purif...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1990.tb01973.x

    authors: Yoshida K,Arai K,Kobayashi N,Saitoh H

    更新日期:1990-05-01 00:00:00

  • Significance of CFTR gene mutations in patients with congenital aplasia of vas deferens with special regard to renal aplasia.

    abstract::Between 1994 and 2010, a total of 123 patients with obstructive azoospermia due to aplasia of vas deferens (CAVD) were surgically treated. In 110 patients, the condition was bilateral (CBAVD), 13 men had unilateral aplasia (CUAVD), and 10 patients additionally had aplasia of one kidney. All patients underwent CFTR gen...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.2012.01281.x

    authors: Schwarzer JU,Schwarz M

    更新日期:2012-10-01 00:00:00