The effect of p-nonylphenol on the fertility potential of male rats after gestational, lactational and direct exposure.

Abstract:

:There is growing concern that abnormalities in male reproductive health are becoming more frequent. The most fundamental change has been the striking decline in sperm counts and semen quality. The effect of maternal exposure of rats to the oestrogenic environmental substance p-nonylphenol (p-NP) was determined in this study. Exposure to p-NP for the experimental period impaired general growth. The lower testicular mass indicated a direct toxic effect on the testis in animals exposed to p-NP during foetal life, the postnatal period and after weaning until termination at 10 weeks of age. The epididymal mass was also negatively affected by p-NP; this was supported by the decrease in the epididymal ratio. The total cauda epididymal sperm count was significantly lower in the 250 mg kg-1 p-NP dosage group compared to the control and 100 mg kg-1 p-NP groups. The overall lower sperm count with increased p-NP concentrations corresponded with the decreased testicular and epididymal masses. This emphasized the toxicity of p-NP on both testis and epididymis. Seminiferous tubule diameter, lumen diameter and seminiferous epithelium thickness were smaller in the exposed groups, even at the low dose level. These histological measurements further supported the finding of a low testicular mass. In spite of the measurements being smaller, p-NP had no effect on the stages of spermatogenesis except for one animal with disrupted spermatogenesis in some tubules, while others were normal.

journal_name

Andrologia

journal_title

Andrologia

authors

de Jager C,Bornman MS,Oosthuizen JM

doi

10.1046/j.1439-0272.1999.00246.x

keywords:

subject

Has Abstract

pub_date

1999-03-01 00:00:00

pages

107-13

issue

2

eissn

0303-4569

issn

1439-0272

journal_volume

31

pub_type

杂志文章
  • Decreased prostate-specific membrane antigen levels in the seminal plasma of oligoasthenoteratozoospermic men.

    abstract::Prostate-specific membrane antigen (PSMA) is a transmembrane glycoprotein with glutamate carboxypeptidase activity. However, its precise function in the prostate, prostasomes and seminal plasma with regard to male fertility remains unknown. This study was conducted to investigate the seminal plasma PSMA levels in fert...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13840

    authors: Arslan MA,Avcı B,Tunçel ÖK,Asci R

    更新日期:2021-02-01 00:00:00

  • Spermagglutinating antibodies: a comparison of three different techniques.

    abstract::In 136 patients tests were performed to demonstrate circulating spermagglutinating antibodies. In patients with "unexplained" infertility (15 cases) antibodies were demonstrated in six (40%) whereas in patients where another cause for infertility was present (101 cases) additional positive spermagglutinating antibodie...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1980.tb00570.x

    authors: Franken DR,Slabber CF

    更新日期:1980-01-01 00:00:00

  • Some properties of acid and alkaline phosphomonoesterases of chicken spermatozoa.

    abstract::Alkaline (ALP) and acid (ACP) phosphomonoesterases present in the cell-free extracts of the Triton x-100 treated freshly ejaculated chicken spermatozoa were studied of some of their physico-chemical properties. Alkaline phosphomonoesterase was found to have the optimal specific activity at pH 7.6 in 100 mM Tris-HCl bu...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:

    authors: Mohan J,Panda JN,Singh US

    更新日期:1989-01-01 00:00:00

  • New aspects in the treatment of priapism.

    abstract::Recent advances in the understanding of erectile physiology have improved the prompt diagnosis and treatment of priapism. During initial assessment, the physician must distinguish between veno-occlusive low flow (ischemic) and arterial high flow (nonischemic) in order to choose the correct treatment option for each ty...

    journal_title:Andrologia

    pub_type: 杂志文章,评审

    doi:10.1111/j.1439-0272.1999.tb01451.x

    authors: Martínez Portillo FJ,Jünemann KP

    更新日期:1999-01-01 00:00:00

  • The apparent inhibitor of the protein kinase in the human seminal plasma: an explanation.

    abstract::The protein kinase in the human seminal plasma, as assayed by its ability to catalyze the transfer of phosphate from [gama-32P]ATP to the protamine, was found to linearly increase with dilution of the seminal plasma. Extrapolation of the enzyme activity to the undiluted seminal plasma indicated that te protein kinase ...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1981.tb00055.x

    authors: Panyim S

    更新日期:1981-07-01 00:00:00

  • Relationships between personality traits, seminal parameters and hormones in male infertility.

    abstract::In this study we investigated the relationship between personality attitudes, psychopathological symptoms and biological parameters in male infertility. Eighty-four infertile men underwent a psychological and medical examination at our clinic. The psychological tests comprised the Symptom Checklist 90-R, the Toronto A...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:

    authors: Conrad R,Schilling G,Haidl G,Geiser F,Imbierowicz K,Liedtke R

    更新日期:2002-10-01 00:00:00

  • [Determination of the frequency of Y-chromatin positive spermatozoa in relation to the parameters of spermiograms].

    abstract::The percentage of y chromatin positive spermatozoa had been determined using the fluorescence microsopce technique. After staining procedure with Atebrin we counted 44.1 (+/- 3.9)% y poistive sperms, after staining with Quinacrine mustard the amount was 48,4 (+/- 4,3)%. With statistical methods we examined the correla...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:

    authors: Kaiser R,Herrmann WP,Broer KH,Fischer W

    更新日期:1977-01-01 00:00:00

  • Further studies on the effects of pentoxifylline on sperm count and sperm motility in patients with idiopathic oligo-asthenozoospermia.

    abstract::To further investigate the effectiveness of pentoxifylline (trental) treatment in male infertility, we studied 22 young men (mean age 28.4 years) with "idiopathic" oligo-asthenozoospermia treated for 6 months with the drug (1200 mg daily orally). Sperm concentration and sperm motility were determined before therapy, a...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1985.tb01728.x

    authors: Marrama P,Baraghini GF,Carani C,Celani MF,Giovenco P,Grandi F,Montanini V

    更新日期:1985-11-01 00:00:00

  • [Evaluation of semen by electronic spermcounter].

    abstract::The new electronic spermcounter was developed to make andrological routine work easier. The apparatus is a complete microcomputer and has three main functions: The counter function allows to determine the number of spermatozoa and round cells at the same time. The morphological function allows the detailed morphologic...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:

    authors: Pusch H,Wiesspeiner G,Hausl A

    更新日期:1982-03-01 00:00:00

  • Azoospermia and maturation arrest: malfunction of valves in erect poster of humans leads to hypoxia in sperm production site.

    abstract::Maturation arrest (MA) of spermatogenesis is diagnosed on histology as interruption of spermatogenesis before the final stage without impairment of Sertoli or Leydig cells. It is considered a condition of irreversible or absolute infertility. Varicocele, which represents impairment in the testicular venous drainage sy...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.2010.01083.x

    authors: Gat Y,Gornish M,Chakraborty J,Perlow A,Levinger U,Pasqualotto F

    更新日期:2010-12-01 00:00:00

  • Male fertility preservation-Methods, indications and challenges.

    abstract::Male fertility preservation has been steadily increasing over the past two decades. Significant improvements have been achieved in the treatment modalities of cancer and other severe chronic medical conditions, leading to an increase in patient survivorship and the resulting demand for future parenthood. Recognition a...

    journal_title:Andrologia

    pub_type: 杂志文章,评审

    doi:10.1111/and.13635

    authors: Grin L,Girsh E,Harlev A

    更新日期:2020-05-11 00:00:00

  • The treatment of male subfertility with kallikrein.

    abstract::In a controlled double blind trial the effectiveness and tolerability of Kallikrein in patients suffering from astheno-oligozoospermia was examined in comparison to placebo. 30 patients with astheno-oligozoospermia of idiopathic origin entered the study; they were subdivided into two homogeneous groups of 15 patients ...

    journal_title:Andrologia

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1439-0272.1984.tb00256.x

    authors: Izzo PL,Canale D,Bianchi B,Meschini P,Esposito G,Menchini Fabris GF,Fasani R,Ohnmeiss H

    更新日期:1984-03-01 00:00:00

  • Progressively motile human spermatozoa are well protected against in vitro lipid peroxidation imposed by induced oxidative stress.

    abstract::Semen samples of 24 patients were analysed. Volumes were measured and the numbers of progressively motile (PMS), motile (MS) and nonmotile spermatozoa (NMS) were determined. These 24 samples appeared to show a large variation in motility percentages and numbers. Spermatozoa of these semen samples were isolated from th...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1046/j.1439-0272.2001.00430.x

    authors: Rhemrev JP,Vermeiden JP,Haenen GR,De Bruijne JJ,Rekers-Mombarg LT,Bast A

    更新日期:2001-05-01 00:00:00

  • Carnitine in seminal fluid as parameter for the epididymal function.

    abstract::Carnitine represents the secretion which is added to human seminal fluid by the epididymis. More than 94% of the free carnitine originates from the epididymis. The frequency distribution of carnitine concentration is investigated with patients showing a normal spermiogram and with those suffering from azoospermia. Cor...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1978.tb03017.x

    authors: Wetterauer U,Heite HJ

    更新日期:1978-05-01 00:00:00

  • Relationship of thyroid to estramustine binding protein (EMBP) concentration in rat prostate.

    abstract::Alternations of estramustine binding protein (EMBP) concentration in rat prostate in relation to androgen status under hypo- and hyperthyroid conditions was estimated by means of radioimmunoassay (RIA). In hyperthyroid rats, EMBP concentration in dorsal as well as in lateral prostate was not significantly changed, but...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1991.tb02518.x

    authors: Shiina H,Sumi H,Ishibe T,Usui T

    更新日期:1991-03-01 00:00:00

  • Ultrastructural localization of lectin binding sites of the acrosomal membrane system of boar spermatozoa.

    abstract::The distribution of the main lectin receptors of boar spermatozoa were analyzed by concanavalin A and Ricinus communis agglutinin-120 visualized for light microscopy by enzymatic amplification with 3-amino-9-ethylcarbazole. The lectin binding sites of the acrosomal membranes in addition to the plasma membrane were dis...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:

    authors: Töpfer-Petersen E,Januschke E,Schmoeckel C,Schill WB

    更新日期:1984-11-01 00:00:00

  • Secretory proteins of human seminal vesicles and their relationship to lipids and sugars.

    abstract::Proteins secreted by human seminal vesicles are strongly positively charged. Cellulose acetate electrophoresis show how the presence of two protein bands of vesicular origin (N3 and N4). When studied on SDS-PAGE there are three main bands of molecular weight 67, 45 and 40 kDa, respectively. These proteins may be separ...

    journal_title:Andrologia

    pub_type: 杂志文章,评审

    doi:10.1111/j.1439-0272.1990.tb02085.x

    authors: Montagnon D,Valtat B,Vignon F,Koll-Back MH

    更新日期:1990-01-01 00:00:00

  • An experimental study: quantitatively evaluating the change of the content of collagen fibres in penis with two-dimensional ShearWave™ Elastography.

    abstract::The purpose of this study was to explore the value of two-dimensional ShearWave™ Elastography (2D-SWE) on quantitatively evaluating the change of the content of collagen fibres in penis. Twenty male Sprague Dawley rats were divided into the pre-sexual maturity group (Group 1) and the sexual decline group (Group 2) acc...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.12653

    authors: Qiao XH,Zhang JJ,Gao F,Li F,Bai M,Du LF,Xing JF

    更新日期:2017-06-01 00:00:00

  • Sperm motile efficiency (SME) of fresh spermatozoa in a hypotonic medium correlates with their cryosurvival in fertile men and infertility patients (predicting test).

    abstract::The sperm motile efficiency (SME) of fresh spermatozoa in a hypotonic medium was investigated concerning the prediction of post thaw motility and the differentiation between fertile men and infertility patients. A total of 95 semen samples were collected for this study. Twenty of these samples were obtained from semen...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1989.tb02425.x

    authors: Glander HJ,Bock H,Winiecki P

    更新日期:1989-07-01 00:00:00

  • Reliable single sperm cryopreservation in Cell Sleepers for azoospermia management.

    abstract::Conventional sperm freezing methods perform best when freezing sperm samples containing at least hundreds of spermatozoa. In this severe male factor infertility case series, we examined the reproductive outcomes in 12 intracytoplasmic sperm injection cases where spermatozoa used were frozen in Cell Sleepers. Cell Slee...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.12434

    authors: Coetzee K,Ozgur K,Berkkanoglu M,Bulut H,Isikli A

    更新日期:2016-03-01 00:00:00

  • Epidemiology and demographics of prostatitis.

    abstract::Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a multifactorial problem affecting men of all ages and demographics. Currently, there is a relative dearth of epidemiological information on CPPS. It is clear that patients with CPPS have a dismal quality of life and many have benefited only minimally from ...

    journal_title:Andrologia

    pub_type: 杂志文章,评审

    doi:10.1046/j.1439-0272.2003.00584.x

    authors: Schaeffer AJ

    更新日期:2003-10-01 00:00:00

  • Effects of two-year testosterone replacement therapy on cognition, emotions and quality of life in young and middle-aged hypogonadal men.

    abstract::The aim of the study was to examine the effects of two-year testosterone replacement therapy on cognitive functioning, emotional state and quality of life in young and middle-aged men with hypogonadotropic hypogonadism. Nineteen males diagnosed with hypogonadotropic hypogonadism participated in the study. Cognitive fu...

    journal_title:Andrologia

    pub_type: 临床试验,杂志文章

    doi:10.1111/and.12633

    authors: Lašaitė L,Čeponis J,Preikša RT,Žilaitienė B

    更新日期:2017-04-01 00:00:00

  • Mitochondria-targeted antioxidant SkQ1 improves spermatogenesis in Immp2l mutant mice.

    abstract::Previous studies have confirmed that spermatogenesis in homozygous Immp2l mutant male mice was normal at the age of 6 months, but was significantly abnormal at the age of 13 months. Meanwhile, oxidative stress is reported to be involved in spermatogenic impairment in old mutant mice. However, it is unclear whether ant...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.12848

    authors: Jiang Y,Liu C,Lei B,Xu X,Lu B

    更新日期:2018-03-01 00:00:00

  • Chloroquine excretion in semen following antimalarial-drug administration.

    abstract::The study described here was carried out to establish whether or not chloroquine was excreted in semen. Chloroquine was assayed in the semen of eight male volunteers (aged between 19 and 45 years) by a fluorimetric method before and after taking a total dose of 1.500 mg chloroquine base corresponding to the accepted d...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1994.tb00782.x

    authors: Adeeko AO,Dada OA

    更新日期:1994-05-01 00:00:00

  • Metabolic evaluation of cooled equine spermatozoa.

    abstract::Microscopy has been used in the routine evaluation of sperm metabolism. Nevertheless, it has limited capacity to preview male fertility. As calorimetry may be used to evaluate directly the metabolic activity of a biological system, the aim of this study was to use microcalorimetry as an additive method for sperm metab...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.2009.00963.x

    authors: Vasconcelos AB,Santana MA,Santos AM,Santoro MM,Lagares MA

    更新日期:2010-04-01 00:00:00

  • The antiapoptotic and antioxidant effects of eugenol against cisplatin-induced testicular damage in the experimental model.

    abstract::Testicular dysfunction or damage is among the critical side effects of chemotherapeutic drugs like cisplatin. This study was mapped out to assess the possible therapeutic effect of eugenol on cisplatin-induced testicular damage. In this experimental study, a single dose of cisplatin (15 mg/kg) was given intraperitonea...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13353

    authors: Ekinci Akdemir FN,Yildirim S,Kandemir FM,Aksu EH,Guler MC,Kiziltunc Ozmen H,Kucukler S,Eser G

    更新日期:2019-10-01 00:00:00

  • The current perspective on genetic and epigenetic factors in sperm maturation in the epididymis.

    abstract::Male infertility affects approximately 30% of infertile couples. As spermatozoa mature in the epididymal lumen, their potential for mobility increases, and their protein, lipid and small RNA (sRNA) content changes, whereas capacitation and fertilisation take place in the female reproductive tract. Both of the latter p...

    journal_title:Andrologia

    pub_type: 杂志文章,评审

    doi:10.1111/and.13989

    authors: Ozkocer SE,Konac E

    更新日期:2021-01-25 00:00:00

  • The effects of bacterial infection on human sperm nuclear protamine P1/P2 ratio and DNA integrity.

    abstract::The purpose of this study was to detect the effects of bacterial infection on human sperm nuclear protamines and DNA fragmentation. In this study, 120 semen samples were collected from unselected male partners of couples consulting for infertility in infertility and obstetrics clinic. All the samples were screened bac...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.12841

    authors: Zeyad A,Hamad MF,Hammadeh ME

    更新日期:2018-03-01 00:00:00

  • Erectile dysfunction in patients with first-episode psychosis.

    abstract::Sexual dysfunction is more prevalent in psychotic patients than in the nonpsychotic population. The objective of this study was to identify correlations between serum prolactin levels, testosterone levels and erectile dysfunction in patients with first-episode psychosis (n = 40) compared to age-matched healthy control...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13793

    authors: Gaber HD,El-Beeh KAM,Abd Al-Naser FAW,Hosny A

    更新日期:2020-12-01 00:00:00

  • Gossypol-induced inhibition of plasminogen activator activity in human and ovine acrosomal extract.

    abstract::The effect of gossypol--a polycyclic compound isolated from cotton seeds--on the plasminogen activator activity of man and ram acrosomal extracts was explored in vitro. The action of gossypol on the plasminogen activator activity was investigated by a spectrophotometric method using the chromogenic substrate S-2251. G...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1046/j.1439-0272.1999.00294.x

    authors: Taitzoglou IA,Tsantarliotou M,Kouretas D,Kokolis NA

    更新日期:1999-12-01 00:00:00