Abstract:
:The effect of gossypol--a polycyclic compound isolated from cotton seeds--on the plasminogen activator activity of man and ram acrosomal extracts was explored in vitro. The action of gossypol on the plasminogen activator activity was investigated by a spectrophotometric method using the chromogenic substrate S-2251. Gossypol, a known antispermatogenic agent, was found to effectively inhibit human and ovine acrosomal plasminogen activator activity. The inhibition was dose-dependent. Plasminogen activator activity from man and ram extracts was completely inhibited by 350 mumol l-1 and 300 mumol l-1 of gossypol, respectively. In additional experiments, low, non-spermicidal concentrations of gossypol (2.5-40 mumol l-1) were found to significantly inhibit plasmin activity in a dose-dependent manner. The results suggest that inhibition of both acrosomal plasminogen activator and plasmin activity is a possible mechanism by which gossypol exerts its antifertility effect, since the plasminogen activator/plasmin system plays a role in the whole process of ovum fertilization.
journal_name
Andrologiajournal_title
Andrologiaauthors
Taitzoglou IA,Tsantarliotou M,Kouretas D,Kokolis NAdoi
10.1046/j.1439-0272.1999.00294.xkeywords:
subject
Has Abstractpub_date
1999-12-01 00:00:00pages
355-9issue
6eissn
0303-4569issn
1439-0272journal_volume
31pub_type
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