Nonarteritic ischaemic optic neuropathy (NAION) after 36 h of intake of sildenafil citrate: first Egyptian case.

Abstract:

:Sildenafil citrate is a selective phosphodiesterase 5 (PDE-5) inhibitor and partial phosphodiesterase 6 inhibitor prescribed for erectile dysfunction. Post-marketing case reports of nonarteritic anterior ischaemic optic neuropathy (NAION) over the past few years suggest a potential link with PDE-5 inhibitors. We report a case of a 48-year-old male patient who had acute vision loss 36 h after the intake of 50 mg sildenafil citrate. NAION occurred at a period of minimal blood level of sildenafil citrate. So, erectile dysfunction drugs must be strongly considered with NAION even though their users may have neither predisposing nor precipitating factors for NAION and even if occurring at a time of minimal blood level of these drugs.

journal_name

Andrologia

journal_title

Andrologia

authors

El-Domyati MM,El-Fakahany HM,Morad KE

doi

10.1111/j.1439-0272.2009.00933.x

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

319-21

issue

5

eissn

0303-4569

issn

1439-0272

pii

AND933

journal_volume

41

pub_type

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