Abstract:
:Prostate-specific membrane antigen (PSMA) is a transmembrane glycoprotein with glutamate carboxypeptidase activity. However, its precise function in the prostate, prostasomes and seminal plasma with regard to male fertility remains unknown. This study was conducted to investigate the seminal plasma PSMA levels in fertile men and patients with oligoasthenoteratozoospermia (OAT) and to analyse its association with sperm parameters. Twenty fertile men and twenty patients admitted at the urology clinic of our institution with the diagnosis of OAT were included in the study. Following semen analysis, seminal plasma was isolated from semen ejaculates. PSMA concentrations in the seminal plasma were determined by ELISA. The correlations between seminal PSMA concentrations and semen parameters were statistically analysed. Seminal plasma PSMA concentration was significantly lower in OAT patients compared to fertile controls (p < .01). In fertile men, PSMA concentration was significantly correlated with the sperm concentration (r = -.481, p < .05), whereas in the patient group no statistically significant correlation was found between the sperm parameters and seminal PSMA level. This is the first study in the literature to investigate PSMA levels in the seminal plasma from infertile men. Decreased levels of seminal plasma PSMA might suggest a role for compromised prostasome function in the pathogenesis of OAT syndrome.
journal_name
Andrologiajournal_title
Andrologiaauthors
Arslan MA,Avcı B,Tunçel ÖK,Asci Rdoi
10.1111/and.13840subject
Has Abstractpub_date
2021-02-01 00:00:00pages
e13840issue
1eissn
0303-4569issn
1439-0272journal_volume
53pub_type
杂志文章相关文献
ANDROLOGIA文献大全abstract::Previous studies showed that exposure to stress or nicotine induced reproductive impairment in male rats. Here, we assessed the effect of an antioxidant (vitamin E) on nicotine-, stress- and nicotine + stress-induced reproductive impairment in male rats. Forty-eight male albino Wistar rats were divided into eight grou...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13050
更新日期:2018-09-01 00:00:00
abstract::The aim of this study was to analyse the impact of assistance on the comprehensibility and reliability of the Turkish version of International Index of Erectile Function (IIEF). In this study, 458 patients were asked to complete the IIEF questionnaire by themselves during their first visit and then once again during t...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.2012.01312.x
更新日期:2013-04-01 00:00:00
abstract::The RNA has been located and proportioned by a spectrophotometric method which absorbs the ultra-violet light. The technique used allows us to execute punctual dosage into the spermatozoon's tail. Each of these punctual dosages makes us realise the RNA localisation; and the sum of these dosages makes us realise the to...
journal_title:Andrologia
pub_type: 杂志文章
doi:
更新日期:1975-01-01 00:00:00
abstract::An aqueous extract of Eurycoma longifolia (Tongkat Ali; TA) roots is traditionally used to enhance male sexuality. Because previous studies are limited to only few sperm parameters or testosterone concentration, this study investigated the in vivo effects of TA on body and organ weight as well as functional sperm para...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.12082
更新日期:2014-05-01 00:00:00
abstract::This study aimed to evaluate the effect of N-acetyl cysteine on the male reproductive system and consensus and classification of data found from previous studies. It is undeniable that N-acetyl cysteine as a powerful antioxidant compound can medicate many diseases such as cardiovascular, kidney, liver and reproductive...
journal_title:Andrologia
pub_type: 杂志文章,评审
doi:10.1111/and.13898
更新日期:2021-02-01 00:00:00
abstract::There is growing concern that abnormalities in male reproductive health are becoming more frequent. The most fundamental change has been the striking decline in sperm counts and semen quality. The effect of maternal exposure of rats to the oestrogenic environmental substance p-nonylphenol (p-NP) was determined in this...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1046/j.1439-0272.1999.00246.x
更新日期:1999-03-01 00:00:00
abstract::Recent studies have revealed a high prevalence of leukocytospermia (> 1 x 10(6) white blood cells ml-1 semen) in male infertility patients in the USA and certain European countries, and have implicated white blood cells as a cause of infertility. Since leukocytospermia may often be attributed to male genital-tract inf...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1994.tb00783.x
更新日期:1994-05-01 00:00:00
abstract::The prime concern of the present work was the analysis of dermatoglyphic patterns in infertile patients presenting with clinically detectable varicocele. In a controlled study conducted on 30 patients and utilizing a slight modification of the original ink method of Cummins and Midlo, the dermatoglyphics on terminal p...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1984.tb00244.x
更新日期:1984-03-01 00:00:00
abstract::The lipid composition of the sperm membrane has been shown to exert a significant effect upon the functional quality of spermatozoa. We have studied fatty acid composition of the phospholipids in spermatozoa in asthenozoospermic and normozoospermic men and determined the ratio of polyunsaturated fatty acids (PUFAs) to...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.2006.00735.x
更新日期:2006-10-01 00:00:00
abstract::The effects of incubation with caffeine at final concentration of 0.5 and 5.0 mM for 30 min at ambient temperature were examined in three normal semen samples and three from asthenozoospermic men. A 50 frames/s microcinematographic analysis of the sperm motility was performed and two characteristic parameters of the t...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1982.tb02295.x
更新日期:1982-09-01 00:00:00
abstract::Parameters were obtained from the reproductive organs of ethanol-fed, gossypol-treated Sprague Dawley rats. The experimental animals were fed either on a normal (15.17%) or low protein (8.00%) diet. Measurements included reproductive organ weights, seminal characteristics, serum concentration of testosterone and histo...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1997.tb00317.x
更新日期:1997-07-01 00:00:00
abstract::Pfaffia glomerata (Spreng.) Pedersen, popularly known as "Brazilian ginseng," is used as medicinal plant in Brazil to treat inflammatory diseases in general. Previous studies showed that its extract increases the nitric oxide (NO) levels. Knowing that NO downregulates steroidogenesis and that alterations in the action...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13328
更新日期:2019-09-01 00:00:00
abstract::The cause of Sertoli cell-only syndrome (SCOS), a condition in which only Sertoli cells line the seminiferous tubules in the testis, is unknown. Three microarray data sets were downloaded from public databases and were used to compare SCOS and control group. A total of 291 genes differentially expressed (Log2 |FC| ≥ 1...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13288
更新日期:2019-08-01 00:00:00
abstract::For the 13 abnormalities under consideration, the mean percentages were found to be the following: irregular head (15.2), microcephalic (9.8), elongated head (5.9), coiled tail (5.8), bent tail (4.7), thin head (4.6), cytoplasmic remains (3.2), macrocephalic (1.6), short tail (1.1), no tail (0.6), duplicate tail (0.5)...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1984.tb00389.x
更新日期:1984-09-01 00:00:00
abstract::Abutilon pannosum (Forst.f.) Schlecht. is used for male sexual performance. In this study, we have investigated aphrodisiac potential of A. pannosum stem bark methanol extract (APM) in rat. Male rats were administered with APM (400 mg/kg) on daily basis for 5, 10 and 15 days. Time interval for mount latency, intromiss...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13404
更新日期:2019-11-01 00:00:00
abstract::The spontaneous acrosomal reaction of mouse spermatozoa during their passage through the male and female genital tract was studied by indirect immunofluorescence staining techniques using antibodies against the outer acrosomal membrane (OAM). Low rates of spontaneously acrosome-reacted spermatozoa could be observed du...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1991.tb02592.x
更新日期:1991-11-01 00:00:00
abstract::Azoospermia factor (AZF) genes on the long arm of the human Y chromosome are involved in spermatogenesis, and microdeletions in the AZF region have been recognised to be the second major genetic cause of spermatogenetic failure resulting in male infertility. While screening for these microdeletions can avoid unnecessa...
journal_title:Andrologia
pub_type: 杂志文章,多中心研究
doi:10.1111/and.12662
更新日期:2017-06-01 00:00:00
abstract::To obtain optimal results with gonadotrophic therapy (HMG/hCG) in infertile males, strict selection of patients is of paramount importance. The use of algorithmic schemes permits the exclusion of patients with primary testicular failure, genetic and non-endocrine causes of infertility. This paper describes a retrospec...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1979.tb02216.x
更新日期:1979-09-01 00:00:00
abstract::The aim of this study was to evaluate the production of artefacts during preparation and observation of human sperm for ultrastructural morphology and analyse the possible reasons of causing these artefacts. Under the scanning electron microscopy, damaged sperm heads (crack or/and rupture), necks (head-neck or head-mi...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13043
更新日期:2018-09-01 00:00:00
abstract::Progressive Motility Sustaining Factor (PMSF) was isolated from human epididymides. PMSF could significantly improve progressive motility of oligozoospermic as well as asthenozoospermic semen. PMSF was found to increase cyclic AMP accumulation by the human spermatozoa indicating its possible mode of action. ...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1981.tb00021.x
更新日期:1981-03-01 00:00:00
abstract::We investigated whether chronic stress, applied from prepuberty to early puberty, interferes with the spermatogenic and androgenic testicular functions. Male pubertal rats (40 days old) were immobilized 6 h per day for 15 days. Plasma concentrations of corticosterone, prolactin and testosterone were significantly augm...
journal_title:Andrologia
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract::Cell-free seminal mRNA (cfs-mRNA) exists in the human ejaculate that is proposed as a potential noninvasive procedure to prognosis pathophysiological conditions. This study applied cfs-mRNA of ESX1, ZMYND15 and its target haploid genes (TNP1 and PRM1) to identify the presence of spermatozoa in men with azoospermia. Th...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13483
更新日期:2020-03-01 00:00:00
abstract::The influence of bacteria and/or leukocytes on the outcome of IVF or ICSI is influenced by three factors which have little in common with in vivo conditions: 1) The process of ejaculate preparation (swim-up, Percoll) with antibiotic buffered media; 2) The small amount of inseminated spermatozoa (100,000 per culture); ...
journal_title:Andrologia
pub_type: 杂志文章,评审
doi:10.1111/j.1439-0272.1998.tb02833.x
更新日期:1998-01-01 00:00:00
abstract::Air pollution constitutes the largest cause of environmental risks today. At present, no scientific publication linking environmental black soot and derangement in the hypothalamus and testis of rats exists. This study investigated the effect of black soot exposure on hypothalamic and testicular functions of male rats...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13866
更新日期:2020-12-01 00:00:00
abstract::The new electronic spermcounter was developed to make andrological routine work easier. The apparatus is a complete microcomputer and has three main functions: The counter function allows to determine the number of spermatozoa and round cells at the same time. The morphological function allows the detailed morphologic...
journal_title:Andrologia
pub_type: 杂志文章
doi:
更新日期:1982-03-01 00:00:00
abstract::Testicular torsion/detorsion induces oxidative/nitrosative stress, inflammation and apoptosis of testicular tissues. Baicalin exerts antioxidant and anti-inflammatory properties. This study investigated the possible protective effect of baicalin against testicular torsion-detorsion injury in rats. Surgical testicular ...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.12580
更新日期:2017-02-01 00:00:00
abstract::A procedure was designed for purification of a human seminal plasma-specific antigen (HSP-antigen) identified by a monoclonal antibody produced in this laboratory (mAb 4E6). Pooled human seminal plasma was fractionated by consecutively applied methods: affinity chromatography on Lentil lectin sepharose, gel chromatogr...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1993.tb02724.x
更新日期:1993-09-01 00:00:00
abstract::Although feeding diets containing the extract powder of Lepidium meyenii (maca), a plant growing in Peru's Central Andes, increases serum testosterone concentration associated with enhanced ability of testosterone production by Leydig cells in male rats, changes in testicular steroidogenesis-related factors by the mac...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.12792
更新日期:2017-12-01 00:00:00
abstract::Previous study conducted in our department showed that 50% ethanolic extract of the root of Ricinus communis possess reversible antifertility effect and a 62-kDa protein (Rp) from this extract is responsible for the antifertility effects. In this study, we compared the spermicidal effect of this Rp with nonoxynol-9 (N...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.2012.01291.x
更新日期:2012-12-01 00:00:00
abstract::The purpose of this study was to compare the serum Folic Acid (FA) levels in patients with Erectile Dysfunction (ED) and healthy controls and whether levels vary with its severity. The study was carried out on 77 sexually active individuals, out of which 41 complained of ED and 36 were apparently normal. Patients were...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13890
更新日期:2021-02-01 00:00:00