Abstract:
:The effects of incubation with caffeine at final concentration of 0.5 and 5.0 mM for 30 min at ambient temperature were examined in three normal semen samples and three from asthenozoospermic men. A 50 frames/s microcinematographic analysis of the sperm motility was performed and two characteristic parameters of the trajectories, the progression velocity (Vp) and the amplitude of lateral head displacement (Ah), were measured. At the lower concentration (0.5 mM) no significant effects on the overall mean values (i.e. for all spermatozoa analyzed over the 6 samples) of Vp Ah were found. However, at 5.0 mM a significant reduction in the overall mean Vp was noted. The individual responses were variable between the 6 samples, but only in two of the asthenozoospermic samples and one normal ejaculate were the slow-swimming (less than 20 micrometer/s) spermatozoa accelerated by caffeine treatment. In other samples a reduction in the velocity of faster-swimming spermatozoa was observed. It would seem preferable to reserve caffeine treatment only for severe cases of asthenozoospermia where the distribution of sperm velocities of skewed towards low values.
journal_name
Andrologiajournal_title
Andrologiaauthors
Serres C,Feneux D,David Gdoi
10.1111/j.1439-0272.1982.tb02295.xsubject
Has Abstractpub_date
1982-09-01 00:00:00pages
454-60issue
5eissn
0303-4569issn
1439-0272journal_volume
14pub_type
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