Assessment of preclinical effect of (+)-catechin hydrate on sexual function: An in silico and in vivo study.

Abstract:

:Considering dopamine-enhancing effect of (+)-catechin, the present study was designed to evaluate dopamine-2 (D2) receptor agonistic and phosphodiesterase-5 (PDE5) enzyme inhibitory effects in in silico and effect on male sexual function of Sprague Dawley rats in vivo. (+)-Catechin and standard (sildenafil and bromocriptine) were docked using Autodock Vina 1.1.2 and visualised by UCSF Chimera 1.14. Significant interactions in terms of binding energies were observed for catechin with both proteins. In in vivo study, the rats were dosed orally for 54 days with (+)-catechin hydrate (50 mg/kg), sildenafil citrate (standard, 4 mg/kg) and carboxymethylcellulose (vehicle, 0.25% w/v). The aphrodisiac effects were evaluated on the day 14, 28, 42 and 54 using the behavioural parameters of mounting and intromission. After the study, animals were sacrificed and testes and spermatozoa were assessed for safety profile. Results showed a significant increase in mount and intromission frequencies and a significant reduction in mount and intromission latencies in the catechin group on all tested days when compared to vehicle control. (+)-Catechin was found to be safe on histology of testes, sperm count, sperm motility and sperm morphology parameters. In conclusion, catechin demonstrated an enhancement in sexual behaviour without eliciting toxicity on the male reproductive system in rats.

journal_name

Andrologia

journal_title

Andrologia

authors

Rai A,Gill M,Kinra M,Dsouza LA,Sumalatha S,Raj S,Shetty R,Nandakumar K,Chamallamudi MR,Kumar N

doi

10.1111/and.13737

subject

Has Abstract

pub_date

2020-07-02 00:00:00

pages

e13737

eissn

0303-4569

issn

1439-0272

pub_type

杂志文章
  • Upregulation of TRPV1 in spinal dorsal root ganglion by activating NGF-TrkA pathway contributes to pelvic organ cross-sensitisation in rats with experimental autoimmune prostatitis.

    abstract::Chronic prostatitis/chronic pelvic pain syndrome (CP⁄CPPS) is the prostate gland inflammation characterised as genitourinary pain in the pelvic region. The rat experimental autoimmune prostatitis (EAP) was achieved to mimic CP⁄CPPS. The expressions of transient receptor potential vanilloid 1 (TRPV1) in the prostate, b...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13302

    authors: Zhang J,Yi QT,Gong M,Zhang YQ,Liu D,Zhu RJ

    更新日期:2019-09-01 00:00:00

  • Effect of Lepidium meyenii (MACA) on sexual desire and its absent relationship with serum testosterone levels in adult healthy men.

    abstract::This study was a 12-week double blind placebo-controlled, randomized, parallel trial in which active treatment with different doses of Maca Gelatinizada was compared with placebo. The study aimed to demonstrate if effect of Maca on subjective report of sexual desire was because of effect on mood or serum testosterone ...

    journal_title:Andrologia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1439-0272.2002.00519.x

    authors: Gonzales GF,Córdova A,Vega K,Chung A,Villena A,Góñez C,Castillo S

    更新日期:2002-12-01 00:00:00

  • Decreased prostate-specific membrane antigen levels in the seminal plasma of oligoasthenoteratozoospermic men.

    abstract::Prostate-specific membrane antigen (PSMA) is a transmembrane glycoprotein with glutamate carboxypeptidase activity. However, its precise function in the prostate, prostasomes and seminal plasma with regard to male fertility remains unknown. This study was conducted to investigate the seminal plasma PSMA levels in fert...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13840

    authors: Arslan MA,Avcı B,Tunçel ÖK,Asci R

    更新日期:2021-02-01 00:00:00

  • Rat sperm immobilisation effects of a protein from Ricinus communis (Linn.): an in vitro comparative study with nonoxynol-9.

    abstract::Previous study conducted in our department showed that 50% ethanolic extract of the root of Ricinus communis possess reversible antifertility effect and a 62-kDa protein (Rp) from this extract is responsible for the antifertility effects. In this study, we compared the spermicidal effect of this Rp with nonoxynol-9 (N...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.2012.01291.x

    authors: Nithya RS,Anuja MM,Rajamanickam C,Indira M

    更新日期:2012-12-01 00:00:00

  • New aspects in the treatment of priapism.

    abstract::Recent advances in the understanding of erectile physiology have improved the prompt diagnosis and treatment of priapism. During initial assessment, the physician must distinguish between veno-occlusive low flow (ischemic) and arterial high flow (nonischemic) in order to choose the correct treatment option for each ty...

    journal_title:Andrologia

    pub_type: 杂志文章,评审

    doi:10.1111/j.1439-0272.1999.tb01451.x

    authors: Martínez Portillo FJ,Jünemann KP

    更新日期:1999-01-01 00:00:00

  • Further studies on the effects of pentoxifylline on sperm count and sperm motility in patients with idiopathic oligo-asthenozoospermia.

    abstract::To further investigate the effectiveness of pentoxifylline (trental) treatment in male infertility, we studied 22 young men (mean age 28.4 years) with "idiopathic" oligo-asthenozoospermia treated for 6 months with the drug (1200 mg daily orally). Sperm concentration and sperm motility were determined before therapy, a...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1985.tb01728.x

    authors: Marrama P,Baraghini GF,Carani C,Celani MF,Giovenco P,Grandi F,Montanini V

    更新日期:1985-11-01 00:00:00

  • Azoospermia and Sertoli-cell-only syndrome: hypoxia in the sperm production site due to impairment in venous drainage of male reproductive system.

    abstract::Sertoli-cell-only (SCO) syndrome, or germ cell aplasia, is diagnosed on testicular biopsy when germ cells are seen to be absent without histological impairment of Sertoli or Leydig cells. It is considered a situation of irreversible infertility. Recent studies have shown that varicocele, a bilateral disease, causes hy...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.2010.01047.x

    authors: Gat Y,Gornish M,Perlow A,Chakraborty J,Levinger U,Ben-Shlomo I,Pasqualotto F

    更新日期:2010-10-01 00:00:00

  • Testosterone in peripheral plasma, spermatic vein and in testicular tissue under basal conditions and after HCG-stimulation in patients with varicocele.

    abstract::The incretory testicular function was tested in 21 patient with varicocele aged 19 to 39 years. In one group baseline testosterone was measured, while a second group received a single injection of 5000 IU HCG. Testosterone was studied in peripheral plasma in the spermatic vein and in testicular tissue. Baseline values...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1983.tb00179.x

    authors: Pirke KM,Vogt HJ,Sintermann R,Spyra B

    更新日期:1983-11-01 00:00:00

  • Melatonin appears to protect against steroidogenic collapse in both mice fed with high-fat diet and H2 O2 -treated TM3 cells.

    abstract::High-fat diets (HFDs) are detrimental to steroidogenesis and male fertility. This study aimed to investigate the protective effects of melatonin (MT) treatment on testicular dysfunction in mice fed with HFD. C57BL/6J male mice were randomly divided into three groups: CTRL, HFD and HFD + MT. MT treatment mitigated the ...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13323

    authors: Chen C,Ling MY,Lin FH,Xu L,Lv ZM

    更新日期:2019-09-01 00:00:00

  • NGF promotes mitochondrial function by activating PGC-1α in TM4 Sertoli cells.

    abstract::Nerve growth factor (NGF), which is required for the survival and differentiation of the nervous system, has been proved to play important roles in male reproductive physiology. Several studies have focused on the roles of NGF in the testes. However, no study has reported on the mechanism of paracrine and autocrine ac...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.12837

    authors: Jiang YW,Zhao Y,Chen SX,Chen L,Li CJ,Zhou X

    更新日期:2018-02-01 00:00:00

  • Meningiomas in three male-to-female transgender subjects using oestrogens/progestogens and review of the literature.

    abstract::Sex hormones have been proposed as a possible risk factor for the development and growth of meningiomas. Hormonal therapy plays a fundamental role in the treatment of male-to-female transgenders and needs to be continued after sex reassignment surgery. Usually, this treatment leads to no adverse events; however, its i...

    journal_title:Andrologia

    pub_type: 杂志文章,评审

    doi:10.1111/and.12550

    authors: Ter Wengel PV,Martin E,Gooren L,Den Heijer M,Peerdeman SM

    更新日期:2016-12-01 00:00:00

  • [Use of the ultrasonic Doppler stethoscope in the diagnosis of varicocele].

    abstract::In cases of varicocele the reverse venous blood flow can be detected by the use of the Doppler-stethoscope in a simple way. Applied to the basic examination of fertility patients this method has proved to be a valuable non-invasive screening in the evaluation of varicoceles including cases with minor clinical symptoms...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:

    authors: Ebert L,Bedbur M,Hofmann N

    更新日期:1980-09-01 00:00:00

  • Determination of sperm-antibodies in sera of sterile women by affinity-chromatography (affinity-chromatography of sperm-antibodies).

    abstract::The total amount of humoral sperm antibody protein is determined following its isolation by affinity-chromatography on spermatozoa. Serum proteins are eluted by Sorensen phosphate buffer. Antibodies attached to spermatozoa suspended in Sephadex G 75 columns resist elution by Sorensen buffer. They can be quantitatively...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1975.tb01236.x

    authors: Gradl T,Mettler L,Schirren C

    更新日期:1975-01-01 00:00:00

  • Effect of nonylphenol on spermatogenesis: A systematic review.

    abstract::Nonylphenol (NP) is known as an environmental pollutant that has adverse effects on the spermatogenesis process. In this review, we focus on (1999-2020) studies on the effect of this pollutant on the sperm parameters and the male reproductive system. Spermatogenesis is a process in which male spermatogonia (primary ge...

    journal_title:Andrologia

    pub_type: 杂志文章,评审

    doi:10.1111/and.13748

    authors: Malmir M,Faraji T,Ghafarizadeh AA,Khodabandelo H

    更新日期:2020-07-14 00:00:00

  • An experimental study: quantitatively evaluating the change of the content of collagen fibres in penis with two-dimensional ShearWave™ Elastography.

    abstract::The purpose of this study was to explore the value of two-dimensional ShearWave™ Elastography (2D-SWE) on quantitatively evaluating the change of the content of collagen fibres in penis. Twenty male Sprague Dawley rats were divided into the pre-sexual maturity group (Group 1) and the sexual decline group (Group 2) acc...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.12653

    authors: Qiao XH,Zhang JJ,Gao F,Li F,Bai M,Du LF,Xing JF

    更新日期:2017-06-01 00:00:00

  • Treatment of male infertility with human gonadotrophins: selection of cases, management and results.

    abstract::To obtain optimal results with gonadotrophic therapy (HMG/hCG) in infertile males, strict selection of patients is of paramount importance. The use of algorithmic schemes permits the exclusion of patients with primary testicular failure, genetic and non-endocrine causes of infertility. This paper describes a retrospec...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1979.tb02216.x

    authors: Lunenfeld B,Olchovsky D,Tadir Y,Glezerman M

    更新日期:1979-09-01 00:00:00

  • Studies on the phytomodulatory potential of fenugreek (Trigonella foenum-graecum) on bisphenol-A induced testicular damage in mice.

    abstract::Bisphenol A (BPA), an organic synthetic compound and endocrine disruptor, which majorly cause deleterious effects on male reproductory system. Fenugreek (Trigonella foenum-graecum), associated with Leguminosae family is used as a herbal medicine with potent antioxidant properties. The present study was aimed to scruti...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13492

    authors: Kaur S,Sadwal S

    更新日期:2020-03-01 00:00:00

  • Metabolic evaluation of cooled equine spermatozoa.

    abstract::Microscopy has been used in the routine evaluation of sperm metabolism. Nevertheless, it has limited capacity to preview male fertility. As calorimetry may be used to evaluate directly the metabolic activity of a biological system, the aim of this study was to use microcalorimetry as an additive method for sperm metab...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.2009.00963.x

    authors: Vasconcelos AB,Santana MA,Santos AM,Santoro MM,Lagares MA

    更新日期:2010-04-01 00:00:00

  • Microvasculature of the human testis in correlation to Leydig cells and seminiferous tubules.

    abstract::The microvasculature of the human testis is closely related to the Leydig cells and the seminiferous tubules. Semi-thin sections of testicular tissue serve as a basis for the computer-aided 3-D reconstruction of the microvasculature, the seminiferous tubules and the Leydig cells. After vascular perfusion with glutaral...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1994.tb00799.x

    authors: Ergün S,Stingl J,Holstein AF

    更新日期:1994-09-01 00:00:00

  • Control of gonadotropin secretion in prepubertal male rats by excitatory amino acids.

    abstract::The role of N-methyl-D-aspartate (NMDA) and non-NMDA receptors in the control of FSH and LH secretion was analysed in prepubertal male rats. In the first experiment 4, 8, 12, 16, 20 and 30-day-old males were decapitated 15 min after vehicle, NMDA or kainic acid (KA) administration. In the second experiment, 23-day-old...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1996.tb02776.x

    authors: Aguilar E,Tena-Sempere M,Gonzalez D,Pinilla L

    更新日期:1996-05-01 00:00:00

  • The effects of pirfenidone on ischaemia-reperfusion injury in testicular torsion-induced rat model.

    abstract::The aim of this study was to analyse the effect of pirfenidone against ischaemia-reperfusion injury occurring after detorsion in rats with induced testicular torsion model. Group 1 was assigned as the control group. Group 2 first had testis torsion performed, and then, testicular detorsion was performed. Group 3 had s...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13922

    authors: Kölükçü E,Firat F,Deresoy FA,Katar M,Atılgan D

    更新日期:2020-11-26 00:00:00

  • Spatiotemporal expression patterns of natriuretic peptides in rat testis and epididymis during postnatal development.

    abstract::Natriuretic peptide (NP) family is composed of atrial, brain and C-type NP (NPPA, NPPB and NPPC). Here, we aimed to investigate NP expression in testis and epididymis during postnatal development. NPPA expression was observed in gonocytes at prepubertal period but in only spermatocytes in pachytene and leptotene/zygot...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13387

    authors: Özbek M,Hitit M,Öztop M,Beyaz F,Ergün E,Ergün L

    更新日期:2019-11-01 00:00:00

  • Correlation of biochemical constituents of seminal plasma with semen quality in Teddy goat (Capra hircus) bucks.

    abstract::This study was planned to determine the relationship between semen quality parameters and the levels of biochemical constituents of seminal plasma of Teddy (Capra hircus) buck semen. For this purpose, semen ejaculates were collected from five mature healthy Teddy bucks. All the experimental bucks were kept under natur...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.12940

    authors: Umar S,Ahmad M,Ahmad I,Zubair M,Umar Z,Qureshi AS,Manzoor A,Murtaza A,Shaukat A

    更新日期:2018-04-01 00:00:00

  • Retracted: Aetiology and clinical profile of children with 46, XY differences of sex development at an Indian referral centre.

    abstract::Retraction: 'Aetiology and clinical profile of children with 46, XY differences of sex development at an Indian referral centre' by Vasundhera Chauhan, Rima Dada, Vandana Jain The above article, published online on 8 August 2016 in Wiley Online Library (http://wileyonlinelibrary.com), has been retracted by agreement b...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.12663

    authors: Chauhan V,Dada R,Jain V

    更新日期:2017-11-01 00:00:00

  • Nutrient patterns and asthenozoospermia: a case-control study.

    abstract::The association of dietary nutrient patterns and sperm motility is not yet well elucidated, and previous studies have just focused on the isolated nutrients. This case-control study examined the association of nutrient patterns with asthenozoospermia among Iranian men. In total, 107 incident asthenozoospermic men and ...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.12624

    authors: Eslamian G,Amirjannati N,Rashidkhani B,Sadeghi MR,Hekmatdoost A

    更新日期:2017-04-01 00:00:00

  • The effects of hesperidin on colistin-induced reproductive damage, autophagy, and apoptosis by reducing oxidative stress.

    abstract::This study has been conducted to investigate the effect of hesperidin on colistin-induced reproductive damage in male rats. Twenty-four adult male Sprague Dawley rats were used as animal material. They were divided into four groups: control group, received physiological saline for 7 days by oral gavage; hesperidin gro...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13900

    authors: Aksu EH,Kandemir FM,Küçükler S

    更新日期:2020-12-01 00:00:00

  • Dietary omega-3 polyunsaturated fatty acids induce plasminogen activator activity and DNA damage in rabbit spermatozoa.

    abstract::The aim of this study was to determine the effect(s) of dietary omega-3 polyunsaturated fatty acids (ω-3 PUFA) on rabbit semen. Adult rabbit bucks were assigned to two groups that were given two diets, a standard diet (control) and a diet supplemented with ω-3 PUFA. Sperm samples were collected from all bucks with the...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.12776

    authors: Kokoli AN,Lavrentiadou SN,Zervos IA,Tsantarliotou MP,Georgiadis MP,Nikolaidis EA,Botsoglou N,Boscos CM,Taitzoglou IA

    更新日期:2017-12-01 00:00:00

  • Personality, coping and sperm count.

    abstract::Previous research has suggested an association between personality traits and coping, as well as between coping and sperm concentration. In the present study, both domains of research were combined, leading to the formulation of specific hypotheses. A total of 54 healthy volunteers were given questionnaires twice to a...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.2004.00647.x

    authors: Pook M,Tuschen-Caffier B,Kubek J,Schill WB,Krause W

    更新日期:2005-02-01 00:00:00

  • Anatomical endoscopic enucleation of the prostate: The next gold standard? Yes!

    abstract::Anatomical endoscopic enucleation of the prostate (AEEP) differs from other surgical techniques for benign prostatic obstruction (BPO) in that it removes the entire benign prostatic hyperplasia (BPH) component of the prostate. We summarise the main advantages of AEEP compared to other surgical techniques for BPO. Thes...

    journal_title:Andrologia

    pub_type: 杂志文章,评审

    doi:10.1111/and.13643

    authors: Aho T,Armitage J,Kastner C

    更新日期:2020-09-01 00:00:00

  • Two esterases common to seminal plasma, other external secretions and leucocytes in man.

    abstract::Two esterases previously identified in seminal plasma, on the basis of their electrophoretic mobility, immunogenicity and sensitivity to organophosphorus esters were detected in various human external secretions and leucocyte extracts. alpha-Esterase was found to be abundant in urine and milk whereas this enzyme occur...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1976.tb01650.x

    authors: Roberts TK,Masson PL,Lauwerys R,Heremans JF

    更新日期:1976-01-01 00:00:00