Treatment of male infertility with human gonadotrophins: selection of cases, management and results.

Abstract:

:To obtain optimal results with gonadotrophic therapy (HMG/hCG) in infertile males, strict selection of patients is of paramount importance. The use of algorithmic schemes permits the exclusion of patients with primary testicular failure, genetic and non-endocrine causes of infertility. This paper describes a retrospective study on the results of gonadotrophic therapy in 25 severe oligozoospermic males, preselected according to the above scheme and in whom levels of FSH, LH and Testosterone before and during GnRH stimulation were assessed. This study indicates that low basal levels of FSH, concomitant with low or lack of FSH response to GnRH stimulation may be useful in selection of patients with a fair chance of success for gonadotrophic therapy.

journal_name

Andrologia

journal_title

Andrologia

authors

Lunenfeld B,Olchovsky D,Tadir Y,Glezerman M

doi

10.1111/j.1439-0272.1979.tb02216.x

subject

Has Abstract

pub_date

1979-09-01 00:00:00

pages

331-6

issue

5

eissn

0303-4569

issn

1439-0272

journal_volume

11

pub_type

杂志文章
  • Finasteride-related Leydig cell tumour: report of a case and literature review.

    abstract::Leydig cell tumours (LCTs) of the testis are rare. Their origin is still unknown. This case report describes a potential relationship between LCT and prolonged exposure to Finasteride. ...

    journal_title:Andrologia

    pub_type: 杂志文章,评审

    doi:10.1111/j.1439-0272.2011.01214.x

    authors: Berthold D,Lhermitte B,Uffer M,Doerfler A

    更新日期:2012-05-01 00:00:00

  • A new perspective on penis length measurement in children: How healthy are the results obtained with the current techniques?

    abstract::In order to detect abnormalities in the size of the penis, firstly, the penis length must be measured correctly. Controversies about the best technique on to be used to measure the length of the penis still persist. The hypothesis of this study is to show that penile length in children is longer than measured under no...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13864

    authors: Akyüz O

    更新日期:2020-12-01 00:00:00

  • The treatment of male subfertility with kallikrein.

    abstract::In a controlled double blind trial the effectiveness and tolerability of Kallikrein in patients suffering from astheno-oligozoospermia was examined in comparison to placebo. 30 patients with astheno-oligozoospermia of idiopathic origin entered the study; they were subdivided into two homogeneous groups of 15 patients ...

    journal_title:Andrologia

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1439-0272.1984.tb00256.x

    authors: Izzo PL,Canale D,Bianchi B,Meschini P,Esposito G,Menchini Fabris GF,Fasani R,Ohnmeiss H

    更新日期:1984-03-01 00:00:00

  • The current perspective on genetic and epigenetic factors in sperm maturation in the epididymis.

    abstract::Male infertility affects approximately 30% of infertile couples. As spermatozoa mature in the epididymal lumen, their potential for mobility increases, and their protein, lipid and small RNA (sRNA) content changes, whereas capacitation and fertilisation take place in the female reproductive tract. Both of the latter p...

    journal_title:Andrologia

    pub_type: 杂志文章,评审

    doi:10.1111/and.13989

    authors: Ozkocer SE,Konac E

    更新日期:2021-01-25 00:00:00

  • The ameliorative effects of methylene blue on testicular damage induced by cisplatin in rats.

    abstract::Cisplatin, a common chemotherapeutic drug, can induce testicular toxicity. Methylene blue, a potent antioxidant, can inhibit the generation of free radicals. This research aimed to study the protective effect of methylene blue against the cisplatin-induced toxicity of the reproductive system in rats. 35 male Wistar ra...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13850

    authors: Gholami Jourabi F,Yari S,Amiri P,Heidarianpour A,Hashemi H

    更新日期:2021-02-01 00:00:00

  • Microsurgical subinguinal cremaster muscle release for chronic orchialgia secondary to hyperactive cremaster muscle reflex in adults.

    abstract::A careful history and evaluation of men with chronic orchialgia elucidates the aetiology in some men to be a hyperactive cremaster muscle reflex with testicular retraction as the cause. The objective is to evaluate outcomes in men who underwent microsurgical subinguinal cremaster muscle release (MSCMR) with a retrospe...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13493

    authors: Kavoussi PK

    更新日期:2020-02-01 00:00:00

  • Pulmonary embolism complicating human chorionic gonadotropin treatment in a patient with type IV hyperlipoproteinemia.

    abstract::Human chorionic Gonadotropin (HCG) therapy has been used beneficially in men with subfertility especially after varicocele surgery. Very few side effects have been observed in male patients. Herein, we report a case of pulmonary embolism in a male patient following the use of HCG. The patient was subsequently found to...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1987.tb01861.x

    authors: Dhabuwala CB,Kumar A,Pierce JM

    更新日期:1987-01-01 00:00:00

  • A study on the association between serum amyloid A and sperm concentration.

    abstract::Our aim was to compare peripheral blood and seminal fluid serum amyloid A (SAA) protein levels in men classified on the basis of sperm concentration and investigate whether SAA protein is an important marker of male infertility. A total of 74 first-attempt IVF male partners of infertile couples classified as azoosperm...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.12491

    authors: Timur H,Kokanali MK,Inal HA,Tuzluoglu D,Yilmaz N

    更新日期:2016-08-01 00:00:00

  • Metabolic evaluation of cooled equine spermatozoa.

    abstract::Microscopy has been used in the routine evaluation of sperm metabolism. Nevertheless, it has limited capacity to preview male fertility. As calorimetry may be used to evaluate directly the metabolic activity of a biological system, the aim of this study was to use microcalorimetry as an additive method for sperm metab...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.2009.00963.x

    authors: Vasconcelos AB,Santana MA,Santos AM,Santoro MM,Lagares MA

    更新日期:2010-04-01 00:00:00

  • Embryonic exposure to dimethoate and/or deltamethrin impairs sexual development and programs reproductive success in adult male offspring mice.

    abstract::Pesticides can be toxic to desirable plants and animals, including humans. The aim of this study was to investigate the reproductive effects of low doses of pesticides on male offspring of exposed pregnant mice. Three groups of five female mice were treated daily by oral gavage with dimethoate (5 mg kg(-1) per day), d...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.2011.01246.x

    authors: Ben Slima A,Ben Abdallah F,Keskes-Ammar L,Mallek Z,El Feki A,Gdoura R

    更新日期:2012-05-01 00:00:00

  • Changes in sexual performance and biochemical characterisation of functional neural regions: A study in serotonin transporter knockout male rats.

    abstract::To explore the correlation between SERT expression and sexual activities and seek the possible mechanism of SERT in regulating ejaculations, we analysed the sexual activities and biochemical characteristics of five measured neural regions in three rat genotypes (SERT-/- , SERT+/- and SERT+/+ ). The results showed the ...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13291

    authors: Geng H,Peng D,Huang Y,Tang D,Gao J,Zhang Y,Zhang X

    更新日期:2019-08-01 00:00:00

  • Effect of chronic chloroquine treatment on prostaglandin and human chorionic gonadotropin (hCG) stimulation of testosterone secretion by the rat testis.

    abstract::The effect of chronic chloroquine administration on prostaglandin E1 (PGE1) and human chorionic gonadotropin (hCG) stimulation of testosterone secretion by the rat Leydig cells was studied. Adult albino (Wistar strain) rats were injected with 4 mg/kg body weight of chloroquine phosphate every other day for 30 days. At...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1987.tb01900.x

    authors: Nduka EU,Dada OA

    更新日期:1987-09-01 00:00:00

  • Impact of physician assistance on the reliability of the International Index of Erectile Function.

    abstract::The aim of this study was to analyse the impact of assistance on the comprehensibility and reliability of the Turkish version of International Index of Erectile Function (IIEF). In this study, 458 patients were asked to complete the IIEF questionnaire by themselves during their first visit and then once again during t...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.2012.01312.x

    authors: Bayraktar Z,Atun I

    更新日期:2013-04-01 00:00:00

  • [Morphologic studies of spermatozoa in disorders of motility].

    abstract::On the basis of microscopical examination and further differentiation by special stain techniques, a new classification of defects of midpieces and tails of spermatozoa will be presented: First degree disorders i.e. abnormalities of the staining behaviour and minor structural defects, second degree disorders revealing...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:

    authors: Haidl G,Hartmann R,Hofmann N

    更新日期:1987-07-01 00:00:00

  • Quantitative and ultrastructural study of germinal epithelium in testicular biopsies with "mixed atrophy".

    abstract::In 17 cases of male sterility with so-called "mixed atrophy" in testicular biopsies, the germinal epithelium was investigated by quantitative as well as by ultrastructural means. In 13 cases, the number of spermatids only was reduced, in 2 cases earlier stages of germinal cells were diminished also. Normal quantitativ...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1981.tb00074.x

    authors: Sigg C,Hedinger C

    更新日期:1981-09-01 00:00:00

  • Evaluation of dapoxetine treatment success in lifelong premature ejaculation patients with penile sympathetic skin response.

    abstract::Hyperactivity of the sympathetic nervous system may play an important role in primary premature ejaculation (PPE), and dapoxetine, a selective serotonin reuptake inhibitor, plays a role in its treatment. We evaluated the success of dapoxetine treatment in PPE patients with a penile sympathetic skin response (PSSR). Of...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13076

    authors: Kati B,Ay H

    更新日期:2018-11-01 00:00:00

  • Sperm fluorescent in situ hybridisation study of interchromosomal effect in six Tunisian carriers of reciprocal and Robertsonian translocations.

    abstract::Carriers of structural chromosomal anomalies, translocations and inversions are at increased risk of aneuploid gametes production. Besides the direct effect on the involved chromosomes, these rearrangements might disturb the segregation of other structurally normal chromosomes during meiosis. Such event is known as in...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.12949

    authors: Hajlaoui A,Slimani W,Kammoun M,Sallem A,Braham S,Bibi M,Saad A,Mougou-Zerelli S

    更新日期:2018-01-15 00:00:00

  • Cytoprotective and anti-apoptotic effects of Satureja khuzestanica essential oil against busulfan-mediated sperm damage and seminiferous tubules destruction in adult male mice.

    abstract::We studied the protective effect of Satureja khuzestanica essential oil (SKEO) against damage caused by busulfan on testis in male mice. The NMRI mice (n = 40) were assigned to four groups including: G1: control, G2: treated with busulfan for 4 days (3.2 mg kg(-1)), G3: receive busulfan (4 days, 3.2 mg kg(-1)) and SKE...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.12421

    authors: Nasimi P,Vahdati A,Tabandeh MR,Khatamsaz S

    更新日期:2016-02-01 00:00:00

  • The Estonian version of the National Institutes of Health chronic prostatitis symptom index.

    abstract::Our aim was to establish the Estonian version of the National Institutes of Health chronic prostatitis symptom index (NIH-CPSI), and to examine its validity and applicability in chronic prostatitis patients as well as in community-based study. The questionnaire was tested in 54 category III prostatitis patients. In ad...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.2006.00723.x

    authors: Korrovits P,Punab M,Mehik A,Mändar R

    更新日期:2006-06-01 00:00:00

  • Effect of flutamide on the physiological status of epididymis and epididymal sperms.

    abstract::Flutamide, a pure antiandrogen, increases the levels of plasma luteinizing hormone but antagonizes the biological expression of androgen on target organs. Flutamide was administered to rats to study the effect of altered availability of hormones on the functional status of epididymis. The weights of ventral prostate, ...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1992.tb02620.x

    authors: Mukherjee M,Chattopadhyay S,Mathur PP

    更新日期:1992-03-01 00:00:00

  • Seminal lipids as energy substrate for the spermatozoa.

    abstract::The level of fructose, NEFA, triglycerides and lipase activity were determined in the semen of 17 normozoospermic, 10 oligozoospermic and 10 azoospermic men. This was done immediately and 2 hours after seminal liquefaction. The levels of fructose and NEFA were significantly decreased while triglycerides show significa...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1983.tb00372.x

    authors: Abdel Aziz MT,El-Haggar S,Tawadrous GA,Hamada T,Shawky MA,Amin KS

    更新日期:1983-05-01 00:00:00

  • Nasturtium Officinale L. hydroalcoholic extract improved oxymetholone-induced oxidative injury in mouse testis and sperm parameters.

    abstract::Testicular tissue and sex hormones are sensitive to the anabolic steroids (oxymetholone/OM) due to increased free radical damage and hormonal changes. The Nasturtium officinale L. have various antioxidant compounds. The aim of the present study was to investigate N. officinale effect on OM-induced oxidative injury in ...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13294

    authors: Akbari Bazm M,Khazaei M,Khazaei F,Naseri L

    更新日期:2019-08-01 00:00:00

  • Efficacy and safety of testosterone replacement gel for treating hypogonadism in men: Phase III open-label studies.

    abstract::Efficacy and safety of testosterone gel 2% (TG) were evaluated in two phase 3, open-labelled, single-arm, multicentre studies (000023 and extension study 000077). Hypogonadal men having serum testosterone levels <300 ng/dl at two consecutive measurements were included. Study duration was 9 months (000023: 3 months; 00...

    journal_title:Andrologia

    pub_type: 杂志文章,多中心研究

    doi:10.1111/and.12801

    authors: Belkoff L,Brock G,Carrara D,Neijber A,Ando M,Mitchel J

    更新日期:2018-02-01 00:00:00

  • Glutathione S-transferase M1 and T1 polymorphisms in Turkish patients with varicocele.

    abstract::Several studies have shown that high oxidative stress levels are associated with varicocele. The GST (glutathione S-transferase) family of genes is critical in the protection of cells from oxidative stress because they utilise as substrates a wide variety of products of oxidative stress. The objective of this study wa...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.2010.01103.x

    authors: Acar H,Kılınç M,Guven S,Inan Z

    更新日期:2012-02-01 00:00:00

  • Causes of infertility in men with Down syndrome.

    abstract::Men with Down syndrome are considered as infertile although the causes of infertility are not known in detail yet. Although this constitutes a general rule there are three confirmed cases of parenting by fathers with Down syndrome. Many investigators have addressed the causes of infertility and their studies indicate ...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.2010.01043.x

    authors: Stefanidis K,Belitsos P,Fotinos A,Makris N,Loutradis D,Antsaklis A

    更新日期:2011-10-01 00:00:00

  • Grape seed extract attenuates dexamethasone-induced testicular and thyroid dysfunction in male albino rats.

    abstract::This study scrutinised the ameliorative properties of grape seed extract (GSE) in dexamethasone (DEX)-induced testicular and thyroid dysfunction associated with oxidative stress in male albino rats. Thirty-two healthy adult male albino rats were divided into four groups of eight animals each: normal, DEX control, DEX ...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13002

    authors: Hasona NA

    更新日期:2018-06-01 00:00:00

  • [Separation of motile spermatozoa by "Separon" as measured by a videomicrography computer system].

    abstract::By means of a recently developed apparatus ("Separon") motile spermatozoa were concentrated in a small volume of culture medium (0,3 ml). Sperm concentration, progressive motility and mean velocity of 60 ejaculates were determined by a computerized videomicrography system. After "Separon" sperm concentration was reduc...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:

    authors: Wölbling RH,Pemper B,Möslein S,Milbradt R,Taubert HD

    更新日期:1988-01-01 00:00:00

  • Disordered APC/C-mediated cell cycle progression and IGF1/PI3K/AKT signalling are the potential basis of Sertoli cell-only syndrome.

    abstract::The cause of Sertoli cell-only syndrome (SCOS), a condition in which only Sertoli cells line the seminiferous tubules in the testis, is unknown. Three microarray data sets were downloaded from public databases and were used to compare SCOS and control group. A total of 291 genes differentially expressed (Log2 |FC| ≥ 1...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13288

    authors: Zhang H,Zhou D,Zhu F,Chen F,Zhu Y,Yu R,Fan L

    更新日期:2019-08-01 00:00:00

  • Decreased prostate-specific membrane antigen levels in the seminal plasma of oligoasthenoteratozoospermic men.

    abstract::Prostate-specific membrane antigen (PSMA) is a transmembrane glycoprotein with glutamate carboxypeptidase activity. However, its precise function in the prostate, prostasomes and seminal plasma with regard to male fertility remains unknown. This study was conducted to investigate the seminal plasma PSMA levels in fert...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13840

    authors: Arslan MA,Avcı B,Tunçel ÖK,Asci R

    更新日期:2021-02-01 00:00:00

  • [Andrological findings in adolescents with retractile testis].

    abstract::Approximately between 9 and 19 years of age 28 adolescents with one and 26 with both retractile testicles were andrologically examined and followed up. Retractile gonads during puberty often remained of subnormal size with the long axis shorter than 34 mm. In both groups in 50 to 60% of cases low sperm values were asc...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:

    authors: Raboch J,Pondĕlicková J

    更新日期:1988-09-01 00:00:00