Causes of infertility in men with Down syndrome.

Abstract:

:Men with Down syndrome are considered as infertile although the causes of infertility are not known in detail yet. Although this constitutes a general rule there are three confirmed cases of parenting by fathers with Down syndrome. Many investigators have addressed the causes of infertility and their studies indicate that the causes may be hormonal deficits, morphological alterations of the gonads, abnormal spermatogenesis, psychological and social factors related to the mental retardation. It is obvious that the extra chromosome 21 has a detrimental direct and indirect effect on the reproductive capacity of the affected male patient. But the definite cause of the insufficient and inadequate spermatogenesis remains to be discovered.

journal_name

Andrologia

journal_title

Andrologia

authors

Stefanidis K,Belitsos P,Fotinos A,Makris N,Loutradis D,Antsaklis A

doi

10.1111/j.1439-0272.2010.01043.x

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

353-7

issue

5

eissn

0303-4569

issn

1439-0272

journal_volume

43

pub_type

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