Ameliorative effects of curcumin against acute cadmium toxicity on male reproductive system in rats.

Abstract:

:The aim of the present study was to investigate the ameliorative effect of curcumin (CMN) against acute cadmium chloride (CdCl(2)) toxicity on male reproductive system in rats. CdCl(2) is known to be a heavy metal and potential environmental pollutant. For this purpose, 28 rats were equally divided into four groups; the first group was kept as control and given distilled water and corn oil as carrier. In second and third groups, CdCl(2) and CMN were administered at the dose with 1 mg kg(-1) day(-1) and 100 mg kg(-1) for 3 days respectively. CdCl(2) and CMN were given together at the same doses in the fourth group. It was determined that acute CdCl(2) exposure caused a significant reproductive damage via increased oxidative stress (increased TBARS levels and decreased SOD, CAT, GPx and GSH levels), histological alterations (necrosis, oedema etc.) and spermatological damage (decreased sperm motility and sperm concentration and increased abnormal sperm rate) in male rats. However, CMN treatment partially reversed these toxic effects of CdCl(2) on the reproductive system. In conclusion, our results show that acute exposure of CdCl(2) may lead to infertility, and CMN could prevent and reverse hazardous effects of CdCl(2) to some degree. Thus, CMN may be useful for the prevention of CdCl(2)-induced reproductive damage.

journal_name

Andrologia

journal_title

Andrologia

authors

Oguzturk H,Ciftci O,Aydin M,Timurkaan N,Beytur A,Yilmaz F

doi

10.1111/j.1439-0272.2012.01273.x

subject

Has Abstract

pub_date

2012-08-01 00:00:00

pages

243-9

issue

4

eissn

0303-4569

issn

1439-0272

journal_volume

44

pub_type

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