Abstract:
:Parameters were obtained from the reproductive organs of ethanol-fed, gossypol-treated Sprague Dawley rats. The experimental animals were fed either on a normal (15.17%) or low protein (8.00%) diet. Measurements included reproductive organ weights, seminal characteristics, serum concentration of testosterone and histological, stereological and histomorphometric evaluation of the testis. The testis size, length and diameter of the seminiferous tubule had the least values in the protein-malnourished, gossypol-treated rats (3.01 +/- 0.26 g, 0.56 +/- 0.03 m, 281.34 +/- 11.30 microns), in comparison to corresponding animals which had received ethanol simultaneously with gossypol (3.40 +/- 0.25, 0.71 +/- 0.06 m, 314.42 +/- 11.61 microns). As gossypol and ethanol are both associated with reduced reproductive capacity, this unexpected but interesting finding lends support to the hypothesis that either a normal dietary protein or ethanol consumption may modify the action of gossypol on body tissues, including the testis. This effect, presumably mediated through changes caused to the bioavailability of gossypol, modifies its antifertility activity. The present observation further highlights the need to consider the concurrent administration of other drugs, such as alcohol, and the nutritional status in the evaluation of gossypol for various potential uses.
journal_name
Andrologiajournal_title
Andrologiaauthors
Akingbemi BT,Rao PV,Aire TAdoi
10.1111/j.1439-0272.1997.tb00317.xsubject
Has Abstractpub_date
1997-07-01 00:00:00pages
201-7issue
4eissn
0303-4569issn
1439-0272journal_volume
29pub_type
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