Abstract:
:Intermittent hypobaric hypoxia (IHH) induced a decrease in sperm count and oxidative damage in epididymis. We have previously demonstrated that a blueberry-enriched polyphenol extract (BB-4) reduced the adverse effects of oxidative stress in rat testis under hypobaric hypoxia. The aim of this study was to evaluate whether BB-4 could reverse oxidative stress in epididymis. To evaluate the protective role of BB-4 in epididymis, male rats were exposed to IHH. Lipid peroxidation, (LPO) expression and activity of glutathione reductase (GR) were evaluated. Our results showed a reduction in LPO and a decrease in GR activity in rat epididymis exposed to IHH. These results suggest that BB-4 can prevent the effects of IHH in rat epididymis.
journal_name
Andrologiajournal_title
Andrologiaauthors
Zepeda AB,Calaf GM,Figueroa CA,Farías JGdoi
10.1111/and.12146subject
Has Abstractpub_date
2014-09-01 00:00:00pages
766-9issue
7eissn
0303-4569issn
1439-0272journal_volume
46pub_type
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