Abstract:
:The manual of the World Health Organization defines leucocytospermia as the presence of >1 x 10(6) white blood cells per ml semen. Most authors consider leucocytospermia to be a consequence of inflammation due to bacterial infection. However, the efficacy of antibiotic therapy was not unequivocally demonstrated until now. We started a prospective, randomized, controlled study in 36 patients, who consulted our department for infertility with leucocytospermia. None of the patients reported any symptoms of genital infection. The patients were assigned randomly to two groups: group 1 received 250 mg levofloxacin once a day over 10 days, patients of group 2 received no therapy. Semen analysis was repeated 2 weeks later. After administration of levofloxacin, a mean decrease of leucocyte count of 45.8 +/- 72.2% compared with a decrease of only 3 +/- 109.2% in the untreated group was observed. However, this difference is not statistically significant. There were no significant differences between the two groups with respect to leucocyte count, sperm count and sperm cell after treatment. We conclude from our study that antibiotic therapy does not provide benefit for treatment of asymptomatic leucocytospermia.
journal_name
Andrologiajournal_title
Andrologiaauthors
Krisp A,Hörster S,Skrzypek J,Krause Wdoi
10.1046/j.1439-0272.2003.00580.xkeywords:
subject
Has Abstractpub_date
2003-08-01 00:00:00pages
244-7issue
4eissn
0303-4569issn
1439-0272pii
580journal_volume
35pub_type
临床试验,杂志文章,随机对照试验相关文献
ANDROLOGIA文献大全abstract::Genetic factors that could mediate the pathogenesis of male reproductive disorders are largely unclear. Polymorphisms of cytochrome P4501A1 (CYP1A1), a key enzyme in the extrahepatic metabolism of lipophilic xenobiotics, have been shown to influence susceptibility to xenobiotics. Here, CYP1A1 polymorphisms were invest...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1998.tb01387.x
更新日期:1998-05-01 00:00:00
abstract::An estrogen binding protein has been demonstrated in the cytosol of the epididymis and caudal lobe of prostate of immature rhesus monkey. Scatchard plot analyses were linear, suggesting a single class of high affinity binding sites for the synthetic estrogen, R-2858 (Moxestrol) with a Kd of 5.88 X 10(-10) mol/l and a ...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1985.tb01016.x
更新日期:1985-07-01 00:00:00
abstract::Docetaxel (DTX) has been used in cancer treatments for several decades, but it results in many adverse apoptotic effects through excessive production of reactive oxygen species (ROS) in some tissue including the kidney and testes. We aimed to investigate potential modulatory roles of melatonin (MEL) and selenium (Se) ...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13320
更新日期:2019-09-01 00:00:00
abstract::Searching for further characteristics of sperm in the diagnosis of male infertility it was examined if ejaculates with "normo-, oligo-, astheno-, terato-" and "azoospermia" showed typical modifications in their triglyceride- and phospholipid contents. The examination was conveyed in spermatozoa and seminal plasma. In ...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1984.tb00233.x
更新日期:1984-01-01 00:00:00
abstract::Several drugs have been used to stimulate human sperm motility, including 3-deoxy-adenosine, caffeine, and pentoxifylline. Pentoxifylline is an inhibitor of the phosphodiesterase and may stimulate sperm motility by increasing the intracellular levels of cAMP. In this study we have evaluated the effect of pentoxifyllin...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1993.tb02743.x
更新日期:1993-11-01 00:00:00
abstract::The acrosome is a secretory vesicle located in the sperm head. The acrosome reaction consists in the fusion of the sperm plasma membrane with the external acrosomal membrane. It has been observed that this reaction does not take place in spermatozoa incubated in cervical mucus, hydrogel that contains high concentratio...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.2007.00814.x
更新日期:2008-06-01 00:00:00
abstract::Sex hormones have been proposed as a possible risk factor for the development and growth of meningiomas. Hormonal therapy plays a fundamental role in the treatment of male-to-female transgenders and needs to be continued after sex reassignment surgery. Usually, this treatment leads to no adverse events; however, its i...
journal_title:Andrologia
pub_type: 杂志文章,评审
doi:10.1111/and.12550
更新日期:2016-12-01 00:00:00
abstract::In mice, chronic administration of crude marihuana extract (CME), delta-9-tetrahydrocannabinol (THC), cannabidiol (CBD) and cannabinol (CBN) (50 mg kg-1 body weight for 15 and 35 days) impaired spermatogenesis at both mitotic and meiotic stages. Although the total number of step 7 spermatids was unaltered, mature sper...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1991.tb02520.x
更新日期:1991-03-01 00:00:00
abstract::The aim of this study was to examine whether an association exists between glutathione S-transferase Mu-1 (GSTM1) gene polymorphism and idiopathic male infertility. Sixty men with primary idiopathic infertility and 60 fertile men, serving as controls, were recruited for the study. The polymorphism was analysed using p...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.12306
更新日期:2015-06-01 00:00:00
abstract::The purpose of this study was to detect the effects of bacterial infection on human sperm nuclear protamines and DNA fragmentation. In this study, 120 semen samples were collected from unselected male partners of couples consulting for infertility in infertility and obstetrics clinic. All the samples were screened bac...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.12841
更新日期:2018-03-01 00:00:00
abstract::The scope of this study was to evaluate the accuracy, precision and specificity of the sperm concentration measurements by the Strömberg-Mika Cell Motion Analyser (SM-CMA). Our data show that the instrument generally underscores the sperm concentration and therefore the uncorrected measurements must be corrected by th...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1995.tb02096.x
更新日期:1995-01-01 00:00:00
abstract::The aim of this study was to assess seminal reactive oxygen species (ROS)-antioxidants relationship in fertile and infertile men with and without varicocele. One hundred and seventy six males were studied; fertile healthy volunteers (n = 45), fertile men with varicocele (n = 45), infertile oligoasthenozoospermia (OA, ...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.2008.00900.x
更新日期:2009-04-01 00:00:00
abstract::Cyclophosphamide is a drug used for chemotherapy and as an immune-suppressive in the organ transplantation. Despite its many clinical implications in the treatment of cancers, this drug has toxic effects on the reproductive system. This study aimed to evaluate the effect of ghrelin against the damages caused by cyclop...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.12883
更新日期:2018-03-01 00:00:00
abstract::Sperm morphology has been consistently correlated with fertilisation success or failure. The clinical relevance of the percentage normal spermatozoa has been a widely discussed topic amongst infertility specialists and scientists. This study aimed to evaluate the role of sperm morphology as an indicator of additional ...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.12324
更新日期:2015-08-01 00:00:00
abstract::Over the past decades, there is an increasing number of association studies of telomere length (TL) and the risk and recurrence of prostate cancer (PCa), but the results are inconsistent. Hence, we identify the relevant studies published in English on or before 10 January 2019 conducting a literature review in the ele...
journal_title:Andrologia
pub_type: 杂志文章,meta分析
doi:10.1111/and.13304
更新日期:2019-08-01 00:00:00
abstract::The seminal plasma of 31 patients were examined for the presence of sperm antibodies and for inhibitory properties on the transformation rates of donor lymphocytes cultured in vitro. Twenty five (80%) of the men revealed apart from fertile semen, no sperm antibody activities while six (20%) patients showed high sperma...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1982.tb03105.x
更新日期:1982-03-01 00:00:00
abstract::The aim of this study was to uncover the protective effect of berberine (BBR), an antioxidant chemical, on experimental varicocele (VCL)-induced adverse effects on cell cycle machinery during early germ cells mitosis. To follow-up this study, 30 mature male Wistar rats were divided into control-sham, nontreated VCL, 5...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.12984
更新日期:2018-02-14 00:00:00
abstract::Recent studies have suggested that maternal characteristics can affect reproductive health of offspring, possibly through pre-natal hormonal influence. Anogenital distance (AGD) is an anthropometric measure which is a sensitive reproductive endpoint of masculinisation. It provides a read-out of pre-natal androgen expo...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.12507
更新日期:2016-08-01 00:00:00
abstract::Proteins secreted by human seminal vesicles are strongly positively charged. Cellulose acetate electrophoresis show how the presence of two protein bands of vesicular origin (N3 and N4). When studied on SDS-PAGE there are three main bands of molecular weight 67, 45 and 40 kDa, respectively. These proteins may be separ...
journal_title:Andrologia
pub_type: 杂志文章,评审
doi:10.1111/j.1439-0272.1990.tb02085.x
更新日期:1990-01-01 00:00:00
abstract::The Fas system is involved in the control of immune system homeostasis and nonfunctional Fas system leads to autoimmune disease in mice and humans. The Fas system is a mechanism through which cells expressing Fas ligand (FasL) induce apoptosis of Fas expressing cells. In mouse and rat, the testis represents the main s...
journal_title:Andrologia
pub_type: 杂志文章,评审
doi:10.1046/j.1439-0272.2003.00538.x
更新日期:2003-02-01 00:00:00
abstract::In this study we determined the effect of reactive oxygen species (ROS) generation during incubation in media at 39 degrees C on ram spermatozoa and the protection by exogenously added antioxidant enzyme, superoxide dismutase (SOD). A novel Cu/Zn-SOD, isolated from the fungal strain Humicola lutea 103 (HLSOD), was use...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.2004.00604.x
更新日期:2004-04-01 00:00:00
abstract::Nonylphenol (NP) is known as an environmental pollutant that has adverse effects on the spermatogenesis process. In this review, we focus on (1999-2020) studies on the effect of this pollutant on the sperm parameters and the male reproductive system. Spermatogenesis is a process in which male spermatogonia (primary ge...
journal_title:Andrologia
pub_type: 杂志文章,评审
doi:10.1111/and.13748
更新日期:2020-07-14 00:00:00
abstract::Two distinctly different components of motility were detected in living early spermatids of the rat using phase contrast microscopy and video-analysis: the primary flagellum (a 9 + 2 axonema) executes wave-like motion in three dimensions. At the same time the flagellum displays alternatively in clockwise and counter-c...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1983.tb00110.x
更新日期:1983-01-01 00:00:00
abstract::To assess the protective effects of Eugenia jambolana extract (EJE) or N-acetyl cysteine (NAC) on testis, cisplatin (CIS, 5 mg kg(-1) bw, single dose) was administered either alone or along with EJE (25 mg kg(-1) bw, alternate day) or NAC (150 mg kg(-1) bw, Day 1 and 4) for 7 days. Significant alterations in serum LH,...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.12247
更新日期:2015-03-01 00:00:00
abstract::Chronic prostatitis/chronic pelvic pain syndrome (CP⁄CPPS) is the prostate gland inflammation characterised as genitourinary pain in the pelvic region. The rat experimental autoimmune prostatitis (EAP) was achieved to mimic CP⁄CPPS. The expressions of transient receptor potential vanilloid 1 (TRPV1) in the prostate, b...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13302
更新日期:2019-09-01 00:00:00
abstract::Bisphenol A (BPA), an organic synthetic compound and endocrine disruptor, which majorly cause deleterious effects on male reproductory system. Fenugreek (Trigonella foenum-graecum), associated with Leguminosae family is used as a herbal medicine with potent antioxidant properties. The present study was aimed to scruti...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13492
更新日期:2020-03-01 00:00:00
abstract::E prostaglandins are formed in seminal vesicles and can be oxygenated by (omega-1)-hydroxylation catalysed by cytochrome P450 to 19(R)-hydroxy metabolites. The latter are not further metabolized. Prostaglandin E1 (PGE1), PGE2, 19-hydroxy-PGE1 and 19-hydroxy-PGE2 were measured in seminal fluid of 95 men, who attended t...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1995.tb01075.x
更新日期:1995-03-01 00:00:00
abstract::Emerging evidence is indicating the importance of hundreds of long noncoding RNAs (lncRNAs) in the occurrence and progression of different malignancies such as prostate cancer (PCa). This study investigated the possible role of HOX transcript antisense intergenic RNA myeloid-specific 1 (HOTAIRM1) in the progression of...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13897
更新日期:2020-12-23 00:00:00
abstract::The aim of the study was to investigate whether the promoter methylation of XRCC1 and ERCC2 genes is associated with sperm DNA fragmentation and chromatin condensation in idiopathic oligoasthenoteratozoospermic men. This study involved 77 infertile men with idiopathic oligoasthenoteratozoospermia and 51 normozoospermi...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13925
更新日期:2020-12-23 00:00:00
abstract::Gamma-glutamyl transpeptidase was purified to apparent homogeneity from human testis by DEAE cellulose, acetone, precipitation, fractionation by ammonium sulphate, Sephacryl S-200 chromatography, Q-Sepharose chromatography and S-Sepharose chromatography following solubilization of the enzyme by Triton X-100. The purif...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1990.tb01973.x
更新日期:1990-05-01 00:00:00