Abstract:
:In mice, chronic administration of crude marihuana extract (CME), delta-9-tetrahydrocannabinol (THC), cannabidiol (CBD) and cannabinol (CBN) (50 mg kg-1 body weight for 15 and 35 days) impaired spermatogenesis at both mitotic and meiotic stages. Although the total number of step 7 spermatids was unaltered, mature spermatozoa recovered from the cauda epididymidis showed severe abnormalities in morphology. Body weight and sex organ weights were not affected markedly but the adrenal gland was hypertrophied. Leydig cell nuclear area was increased by CME and CBD and reduced by CBN. Cannabis deranges several stages of the spermatogenic cycle, most of the activity of the crude extract being attributable to CBN and CBD.
journal_name
Andrologiajournal_title
Andrologiaauthors
Patra PB,Wadsworth RMdoi
10.1111/j.1439-0272.1991.tb02520.xsubject
Has Abstractpub_date
1991-03-01 00:00:00pages
151-6issue
2eissn
0303-4569issn
1439-0272journal_volume
23pub_type
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