Abstract:
:An estrogen binding protein has been demonstrated in the cytosol of the epididymis and caudal lobe of prostate of immature rhesus monkey. Scatchard plot analyses were linear, suggesting a single class of high affinity binding sites for the synthetic estrogen, R-2858 (Moxestrol) with a Kd of 5.88 X 10(-10) mol/l and a concentration of binding sites of 17.0 +/- 4.4 fmol/mg cytosol protein in the epididymis. In the prostate, the concentration of binding sites was 19.7 +/- 3.6 fmol/mg cytosol protein with a Kd of 5.42 X 10(-10) mol/l. In immature castrated monkeys, administration of estradiol dipropionate caused a significant increase in the weight, total protein and sialic acid content of the epididymis. This biological action of estrogen on the epididymis is presumably mediated via estrogen receptor.
journal_name
Andrologiajournal_title
Andrologiaauthors
Kamal N,Agarwal AK,Jehan Q,Setty BSdoi
10.1111/j.1439-0272.1985.tb01016.xsubject
Has Abstractpub_date
1985-07-01 00:00:00pages
339-45issue
4eissn
0303-4569issn
1439-0272journal_volume
17pub_type
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