Abstract:
:The Fas system is involved in the control of immune system homeostasis and nonfunctional Fas system leads to autoimmune disease in mice and humans. The Fas system is a mechanism through which cells expressing Fas ligand (FasL) induce apoptosis of Fas expressing cells. In mouse and rat, the testis represents the main source of constitutive FasL in the body. The roles so far proposed for this molecule in the testis, such as maintenance of immunoprivilege and regulation of physiological germ cell apoptosis, need to be reconsidered as both hypotheses are based on an erroneous cellular location of FasL in the seminiferous epithelium. Recently, we demonstrated that in rodents FasL mRNA is present in germ cells and not in Sertoli cells, and that FasL protein is displayed on the surface of spermatozoa. Here we propose that, for the mouse spermatozoa, the FasL may represent a self-defence mechanism against lymphocytes present in the female genital tract. To verify this hypothesis, we performed crossings between males gld, with nonfunctional FasL, and syngenic or nonsyngenic females. We observed a significant decrease of litter size in outbred crossings with gld males compared with wild-type males, suggesting a possible role of FasL in immunoprotection of the sperm in the female genital tract. The possibility that in humans, by analogy with mouse, FasL plays a self-protective role for the spermatozoon cannot be excluded, and awaits experimental information on the expression of FasL on human sperm cells.
journal_name
Andrologiajournal_title
Andrologiaauthors
Riccioli A,Salvati L,D'Alessio A,Starace D,Giampietri C,De Cesaris P,Filippini A,Ziparo Edoi
10.1046/j.1439-0272.2003.00538.xkeywords:
subject
Has Abstractpub_date
2003-02-01 00:00:00pages
64-70issue
1eissn
0303-4569issn
1439-0272pii
538journal_volume
35pub_type
杂志文章,评审相关文献
ANDROLOGIA文献大全abstract::The objective of this study was to investigate the effect of ultra-rapid freezing (direct immersion in liquid nitrogen) on human spermatozoa in cryogenic vials (≥0.5 ml) at different concentrations of sucrose. After swim-up, the sperm suspensions (N = 58) were diluted with sperm preparation medium and divided into six...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.12131
更新日期:2014-08-01 00:00:00
abstract::Maturation arrest is a common cause of male infertility which has caused worldwide concern, and its pathophysiological process remains further elucidation. Our study aimed to identify genetic characteristics of maturation arrest by comparing gene expression between maturation arrest and normal samples using microarray...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13812
更新日期:2020-12-01 00:00:00
abstract::Seminal oxidative stress plays an important role in male factor infertility (MFI), worldwide. A study was thus undertaken for the first time to establish seminal reactive oxygen species (ROS) as a clinical marker of MFI in a cohort of Sri Lankan males. The nitro blue tetrazolium (NBT) assay for ROS estimation and modi...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.12043
更新日期:2014-03-01 00:00:00
abstract::In this study, the presence of Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, Mycoplasma hominis, Mycoplasma genitalium, Ureaplasma urealyticum and Ureaplasma parvumDNA were investigated using real-time multiplex PCR detection kit in the urine samples of 50 patients who presented to the infertili...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13127
更新日期:2018-12-01 00:00:00
abstract::This study was planned to determine the relationship between semen quality parameters and the levels of biochemical constituents of seminal plasma of Teddy (Capra hircus) buck semen. For this purpose, semen ejaculates were collected from five mature healthy Teddy bucks. All the experimental bucks were kept under natur...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.12940
更新日期:2018-04-01 00:00:00
abstract::The effect of 10 days i.m. treatment of testosterone propionate (TP) on plasma testosterone and accessory reproductive organs were studied in adult (6 to 6 1/2 kg) male rhesus monkeys, housed under natural light conditions using six different dose levels. The study was scheduled in the month of September and October. ...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1979.tb02237.x
更新日期:1979-01-01 00:00:00
abstract::Sperm cell plasma membrane and the outer acrosomal membrane fuse profusely during the acrosome reaction. The process is triggered by extracellular signals that elicit several intracellular events leading ultimately to membrane fusion. We have developed a streptolysin O permeabilizing protocol that selectively affects ...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1996.tb02753.x
更新日期:1996-01-01 00:00:00
abstract::The testis of the donkey was used as a model to study age-related changes in the period between puberty and senium. From the age of 1.5 years to the middle of sexual maturity (5 to 6 years) a number of histophysiological features, all indicative of the spermatogenetic efficiency, increase continuously. Then without a ...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1997.tb00310.x
更新日期:1997-05-01 00:00:00
abstract::The aim of this study was to evaluate the production of artefacts during preparation and observation of human sperm for ultrastructural morphology and analyse the possible reasons of causing these artefacts. Under the scanning electron microscopy, damaged sperm heads (crack or/and rupture), necks (head-neck or head-mi...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13043
更新日期:2018-09-01 00:00:00
abstract::This study was conducted to evaluate the effects of ivermectin (IVM) with therapeutic dose (injected with 0.56 mg/kg b.wt.) either alone or combined with alpha lipoic acid (ALA) (50 mg/kg b.wt daily) on expression of testicular insulin-like growth factor binding protein-3 (IGFBP-3) and heat-shock protein A1 (HSPA1)) g...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.12891
更新日期:2018-04-01 00:00:00
abstract::Residues of chlorinated pesticides--HCB, alpha-, beta-, gamma-, delta-, epsilon-HCH isomers, heptachlor epoxide, DDE and DDT isomers in bilateral testicular biopsy material were determined in gas liquid chromatography with electron capture detector (GLC-ECD). The average levels of chlorinated pesticides residues occur...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1983.tb00196.x
更新日期:1983-11-01 00:00:00
abstract::The objective of the study was to compare the water test and the hypoosmotic test (HOS) in the assessment of the human sperm membrane. A total of 686 semen samples from human male donors were subjected to water and HOS tests after routine semen evaluation. The mean percentage of swollen spermatozoa was 71.8 +/- 9.6% i...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1046/j.1439-0272.2001.00374.x
更新日期:2001-03-01 00:00:00
abstract::This study investigated the effects of rutin against reproductive damage caused by toxic mercury in male rats. Thirty-five Sprague Dawley rats were used. Control group was injected with saline for 7 days. The rutin-100 group received 100 mg/kg/b.w. rutin for 7 days. Mercuric chloride (HgCl2 ) group received 1.23 mg/kg...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13524
更新日期:2020-04-01 00:00:00
abstract::The distribution of the main lectin receptors of boar spermatozoa were analyzed by concanavalin A and Ricinus communis agglutinin-120 visualized for light microscopy by enzymatic amplification with 3-amino-9-ethylcarbazole. The lectin binding sites of the acrosomal membranes in addition to the plasma membrane were dis...
journal_title:Andrologia
pub_type: 杂志文章
doi:
更新日期:1984-11-01 00:00:00
abstract::The adult human Sertoli cells produced lactate, estradiol-17beta, transferrin and inhibin; germ cells modulate synthesis of these compounds. In order to study the functional features of human Sertoli cells in vitro, the aim of this study was to measure the lactic dehydrogenase (LDH), gamma-glutamyl transpeptidase (GGT...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1996.tb02762.x
更新日期:1996-03-01 00:00:00
abstract::A critical review of the gonadotropin therapy in male infertility or hypofertility is presented. In the author's opinion, the poor and conflicting results so far obtained wih this kind of treatment are mainly due to inadequate selection of the patients admitted to the treatment itself. The author stresses some points ...
journal_title:Andrologia
pub_type: 杂志文章,评审
doi:10.1111/j.1439-0272.1981.tb00030.x
更新日期:1981-05-01 00:00:00
abstract::This study was a 12-week double blind placebo-controlled, randomized, parallel trial in which active treatment with different doses of Maca Gelatinizada was compared with placebo. The study aimed to demonstrate if effect of Maca on subjective report of sexual desire was because of effect on mood or serum testosterone ...
journal_title:Andrologia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1046/j.1439-0272.2002.00519.x
更新日期:2002-12-01 00:00:00
abstract::This work aimed to assess seminal plasma reactive oxygen species (ROS)-antioxidants relationship with varicocele grade in infertile men with oligoasthenoteratozoospermia (OAT). The study included 89 infertile OAT men with varicocele divided into grade I (n = 22) and grade II (n = 43), grade III (n = 24) and compared w...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.2010.01111.x
更新日期:2012-02-01 00:00:00
abstract::Chromosome aberration is one of the common causes of male infertility. Isodicentric chromosome is a chromosomal aberration in which two arms of a chromosome are identical in morphology and genetics and connected by two centromeres. We firstly reported a case of infertile male with nonmosaic 46, X, idic (Y) (qter-p11.3...
journal_title:Andrologia
pub_type:
doi:10.1111/and.13536
更新日期:2020-05-01 00:00:00
abstract::The study was performed to measure the impact of testosterone (T) administration on circulating levels of 5alpha-dihydrotestosterone (DHT). Group 1 (32 men; mean age 61 years; mean T 6.9 +/- 1.9 nmol l(-1)) were treated for 15 months with long-acting T undecanoate. Group 2 (23 men, mean age 60 years, mean T 7.6 +/- 2....
journal_title:Andrologia
pub_type: 临床试验,杂志文章
doi:10.1111/j.1439-0272.2008.00857.x
更新日期:2008-10-01 00:00:00
abstract::The aim of the study was to examine the effects of two-year testosterone replacement therapy on cognitive functioning, emotional state and quality of life in young and middle-aged men with hypogonadotropic hypogonadism. Nineteen males diagnosed with hypogonadotropic hypogonadism participated in the study. Cognitive fu...
journal_title:Andrologia
pub_type: 临床试验,杂志文章
doi:10.1111/and.12633
更新日期:2017-04-01 00:00:00
abstract::Abutilon pannosum (Forst.f.) Schlecht. is used for male sexual performance. In this study, we have investigated aphrodisiac potential of A. pannosum stem bark methanol extract (APM) in rat. Male rats were administered with APM (400 mg/kg) on daily basis for 5, 10 and 15 days. Time interval for mount latency, intromiss...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13404
更新日期:2019-11-01 00:00:00
abstract::Oestrus urine was proved as a potential endocrine modulator in alleviating the toxicity induced by 3-methylcholanthrene (3-MC) in male rats. We, in this study, aimed to prove the attributing potential of toxicity alleviation to squalene, an oestrus-specific pheromone in rats. A single dose of 3-methylcholanthrene (25 ...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13117
更新日期:2018-12-01 00:00:00
abstract::The spontaneous acrosomal reaction of mouse spermatozoa during their passage through the male and female genital tract was studied by indirect immunofluorescence staining techniques using antibodies against the outer acrosomal membrane (OAM). Low rates of spontaneously acrosome-reacted spermatozoa could be observed du...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1991.tb02592.x
更新日期:1991-11-01 00:00:00
abstract::Parameters were obtained from the reproductive organs of ethanol-fed, gossypol-treated Sprague Dawley rats. The experimental animals were fed either on a normal (15.17%) or low protein (8.00%) diet. Measurements included reproductive organ weights, seminal characteristics, serum concentration of testosterone and histo...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1997.tb00317.x
更新日期:1997-07-01 00:00:00
abstract::During early development of the human testis the male germ cell first appears as primordial germ cell or gonocyte and enters the prospermatogonial stage after the twelfth week of gestation. Prospermatogonia lack glycogen particles and are connected by intercellular bridges. During the same period in the ovary the fema...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1976.tb02120.x
更新日期:1976-01-01 00:00:00
abstract::The epididymis responds to adverse conditions of misshapen spermatozoa resulting from pathological changes or toxic insults by secretion of a dense matrix that segregates the latter for complete disintegration and dissolution. The objective of this study was to find the source of this matrix and the role-player of dis...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13862
更新日期:2021-02-01 00:00:00
abstract::Concerning four own observations by men in the age of 41-69 years it has been reported about the drug-induced gynecomastia. It can be demonstrated that the spironolactone induced gynecomastia disappeared after stopping this drug. The knowledge of such side effects is the condition for a pre-information of the patient ...
journal_title:Andrologia
pub_type: 杂志文章
doi:
更新日期:1986-01-01 00:00:00
abstract::Oestrogen biosynthesis in ejaculated spermatozoa is an autonomous process, which may influence sperm functions. The purpose of this study was to evaluate the relationship between the expression of aromatase, sperm quality and seminal neutral α-glucosidase marker in semen of Tunisian infertile men: asthenozoospermia (A...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.12058
更新日期:2014-03-01 00:00:00
abstract::The routine spermiogram parameters of 3432 patients born between 1952 and 1971 in the region of Leipzig were determined between January 1975 and March 2000. The patient group aged 24-35 years was characterized by low mobility and relocation living in the main centre of chemical industry with enormous environmental pol...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1046/j.0303-4569.2003.00590.x
更新日期:2003-12-01 00:00:00