Abstract:
:Pfaffia glomerata (Spreng.) Pedersen, popularly known as "Brazilian ginseng," is used as medicinal plant in Brazil to treat inflammatory diseases in general. Previous studies showed that its extract increases the nitric oxide (NO) levels. Knowing that NO downregulates steroidogenesis and that alterations in the action/production of androgens during perinatal life could alter testis development, the present studies sought to investigate the reproductive toxicity of Pfaffia glomerata on male mice exposed to hydroalcoholic extract in utero and during lactation. The present study shows that P. glomerata extract does not alter body weight, tubular diameter and testis function in male mice. Although a reduction in the testis weight was observed in the animals that received the highest dose directly in early post-natal life, our findings show clearly that P. glomerata may not act as an endocrine disruptor, and it is not an "antiandrogenic" compound that could lead to testicular dysgenesis syndrome.
journal_name
Andrologiajournal_title
Andrologiaauthors
Auharek SA,Carollo CA,Oliveira RJ,Cunha-Laura AL,Monreal ACD,Siqueira JM,Costa DS,de Paiva Condé TR,Wollf DIL,Aloysio Amaral Edoi
10.1111/and.13328subject
Has Abstractpub_date
2019-09-01 00:00:00pages
e13328issue
8eissn
0303-4569issn
1439-0272journal_volume
51pub_type
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