Evaluation of the testis function of mice exposed in utero and during lactation to Pfaffia glomerata (Brazilian ginseng).

Abstract:

:Pfaffia glomerata (Spreng.) Pedersen, popularly known as "Brazilian ginseng," is used as medicinal plant in Brazil to treat inflammatory diseases in general. Previous studies showed that its extract increases the nitric oxide (NO) levels. Knowing that NO downregulates steroidogenesis and that alterations in the action/production of androgens during perinatal life could alter testis development, the present studies sought to investigate the reproductive toxicity of Pfaffia glomerata on male mice exposed to hydroalcoholic extract in utero and during lactation. The present study shows that P. glomerata extract does not alter body weight, tubular diameter and testis function in male mice. Although a reduction in the testis weight was observed in the animals that received the highest dose directly in early post-natal life, our findings show clearly that P. glomerata may not act as an endocrine disruptor, and it is not an "antiandrogenic" compound that could lead to testicular dysgenesis syndrome.

journal_name

Andrologia

journal_title

Andrologia

authors

Auharek SA,Carollo CA,Oliveira RJ,Cunha-Laura AL,Monreal ACD,Siqueira JM,Costa DS,de Paiva Condé TR,Wollf DIL,Aloysio Amaral E

doi

10.1111/and.13328

subject

Has Abstract

pub_date

2019-09-01 00:00:00

pages

e13328

issue

8

eissn

0303-4569

issn

1439-0272

journal_volume

51

pub_type

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