Abstract:
:The androgen receptor (AR) is a ligand-activated transcription factor member of the nuclear receptor superfamily. The existence of alternatively spliced variants is well recognised for several members of this superfamily, most of them having functional importance. For example, several testicular oestrogen receptor variants have been suggested to play a role in the regulation of spermatogenesis. However, information on AR variants is mostly related to cancer and androgen insensitivity syndrome (AIS) cases. The objective of this study was to investigate the expression of AR variants in the testis from humans and other vertebrates. Four AR variants [ARΔ2(Stop) , ARΔ2(23Stop) , ARΔ3 and ARΔ4(120)] were identified in human testis. ARΔ2(Stop) and ARΔ3, with exon 2 or 3 deleted, respectively, were also expressed in human liver, lung, kidney and heart. In addition, ARΔ2(Stop) was expressed in rat and gilthead seabream testis, while an ARΔ3 was detected in African clawed frog testis. This is the first report revealing the existence of AR variants in the testis of evolutionarily distant vertebrate species and in nonpathological tissues. These data suggest the functional importance of these novel AR forms and demonstrate a complexity in AR signalling that is not exclusive of pathological conditions.
journal_name
Andrologiajournal_title
Andrologiaauthors
Laurentino SS,Pinto PI,Tomás J,Cavaco JE,Sousa M,Barros A,Power DM,Canário AV,Socorro Sdoi
10.1111/j.1439-0272.2012.01333.xsubject
Has Abstractpub_date
2013-06-01 00:00:00pages
187-94issue
3eissn
0303-4569issn
1439-0272journal_volume
45pub_type
杂志文章相关文献
ANDROLOGIA文献大全abstract::A histochemical study has been made of the localization and changes of lipids, carbohydrates, ATPase and 5'-nucleotidase in fresh and fixed frozen sections of testicular and epididymal components in the normal and alpha-chlorohydrin-treated rats. After treatment with a single low dose of alpha-chlorohydrin, the phosph...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1978.tb03032.x
更新日期:1978-07-01 00:00:00
abstract::Analysis of seminal fluid samples from 20 ADS cases is reported for the first time. A significant decrease in the total volume of complete semen sample and sperm concentration was observed. Percentage of morphologically abnormal sperms was higher in samples from ADS cases than controls, though no linear correlation wa...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1985.tb01714.x
更新日期:1985-11-01 00:00:00
abstract::The study described here was carried out to establish whether or not chloroquine was excreted in semen. Chloroquine was assayed in the semen of eight male volunteers (aged between 19 and 45 years) by a fluorimetric method before and after taking a total dose of 1.500 mg chloroquine base corresponding to the accepted d...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1994.tb00782.x
更新日期:1994-05-01 00:00:00
abstract::This short review summarizes some recent findings on arylhydrocarbon (dioxin) receptor expression during early pregnancy in mammals. The arylhydrocarbon receptor is a ligand-activated transcription factor and was originally described as a mediator of the toxic effects of dioxins and other chlorinated hydrocarbons such...
journal_title:Andrologia
pub_type: 杂志文章,评审
doi:10.1046/j.1439-0272.2000.00397.x
更新日期:2000-09-01 00:00:00
abstract::The aim of this study was to compare the effectiveness of antioxidants including cysteamine (2.5, 7.5 mm), hyaluronan (0.25, 1 mg ml(-1) ) and fetuin (5, 10 mg ml(-1) ) in the freezing of Brown Swiss bull semen. The best percentages of CASA motilities were achieved with 10 mg ml(-1) of fetuin and 2.5 mm of cysteamine....
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.12236
更新日期:2015-03-01 00:00:00
abstract::Tubular hyalinization was studied both light and electron microscopically in 22 cases. 8 of them were found in undescended testes and 5 cases represented possible intermediary forms with only partial hyalinization of the tubules. In these testes spermatogenic arrest, hypospermatogenesis, only Sertoli cells and areas w...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1986.tb01746.x
更新日期:1986-01-01 00:00:00
abstract::In order to investigate whether a hypothalamic disorder cause hypogonadism in male prolactinomas, LH pulsatile secretion was studied in 13 male patients. Serum PRL levels ranged from 186 to 45,000 ng ml-1 before treatment, and all the tumors were macroadenomas. Reduced LH secretion was revealed in 5 of 13 patients, an...
journal_title:Andrologia
pub_type: 杂志文章
doi:
更新日期:1990-11-01 00:00:00
abstract::Several drugs have been used to stimulate human sperm motility, including 3-deoxy-adenosine, caffeine, and pentoxifylline. Pentoxifylline is an inhibitor of the phosphodiesterase and may stimulate sperm motility by increasing the intracellular levels of cAMP. In this study we have evaluated the effect of pentoxifyllin...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1993.tb02743.x
更新日期:1993-11-01 00:00:00
abstract::In order to detect abnormalities in the size of the penis, firstly, the penis length must be measured correctly. Controversies about the best technique on to be used to measure the length of the penis still persist. The hypothesis of this study is to show that penile length in children is longer than measured under no...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13864
更新日期:2020-12-01 00:00:00
abstract::Penile amputation is an uncommon condition for which immediate surgical replantation is warranted. This work aimed to represent intervention and management for an amputated penis by replantation and reconstruction. A 23-year-old man presented with traumatic penile amputation for 2 h where the penile proximal part was ...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.2009.00925.x
更新日期:2009-08-01 00:00:00
abstract::The CAG repeat and its association with infertility has been debatable. Therefore, this study was planned to assess the distribution of CAG repeat expansion in Egyptian patients and to investigate its association with male infertility. Forty-five infertile men were eligible for the study in addition to 20 aged-matched...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.2010.01100.x
更新日期:2012-02-01 00:00:00
abstract::The reduction of sperm motility and subsequently reduced ability to undergo capacitation and acrosome reaction are considered as common causes of male infertility. The β-defensin family is a group of well-known secretory proteins with antimicrobial activity that contribute to the process of "sperm maturation" during t...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13455
更新日期:2020-02-01 00:00:00
abstract::Errors of folate/homocysteine pathways which are critical for transferring methyl groups have been suggested to affect male fertility. We aimed to evaluate the methylation patterns of the promoter of methylenetetrahydrofolate reductase (MTHFR) gene in infertile males and to investigate the association between MTHFR pr...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13942
更新日期:2020-12-28 00:00:00
abstract::The results of a study of 373 cases of male sterility in Tunisia are presented. Factors with negative effects on fertility are listed according to their incidence: hypogonadism, gonococci infection, following varicocele and excessive smoking. Important is; early diagnosis of venereal disease and its effective treatmen...
journal_title:Andrologia
pub_type: 杂志文章
doi:
更新日期:1987-06-01 00:00:00
abstract::Autophagy is a pro-survival mechanism involving lysosomal degradation of damaged cellular components following multiple forms of cellular stress. There is currently a lack of literature on the mechanism, and specifically on mitophagy (selective autophagy of damaged pro-apoptotic mitochondria) in Sertoli cells (SCs). A...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.12820
更新日期:2018-02-01 00:00:00
abstract::The effect of immunosuppression with dexamethasone on sperm antibody formation following vasectomy in men was determined. Vasectomized men were treated with dexamethasone (4 mg) tablets starting two days prior to vasectomy and each day thereafter for a total of eight days for a total dose of 30 mg. There was no signif...
journal_title:Andrologia
pub_type: 临床试验,杂志文章
doi:10.1111/j.1439-0272.1987.tb01907.x
更新日期:1987-11-01 00:00:00
abstract::The cooperation in cases of childlessness between andrologists and gynecologists is an essential of any treatment. In a short communication it was shown that a special investigation form can be helpful for reciprocal information. This investigation form improves the information rate form 10% to 30%. In some cases the ...
journal_title:Andrologia
pub_type: 杂志文章
doi:
更新日期:1987-11-01 00:00:00
abstract::Dynamic assessment of sperm DNA fragmentation (SDF) has shown to give fuller understanding of stallion semen quality; however, there have been limited attempts to use this parameter to investigate seasonal changes in productive functions. The aims of this study were to: (a) establish a reliable mathematical model to d...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13545
更新日期:2020-05-01 00:00:00
abstract::Hyperactivity of the sympathetic nervous system may play an important role in primary premature ejaculation (PPE), and dapoxetine, a selective serotonin reuptake inhibitor, plays a role in its treatment. We evaluated the success of dapoxetine treatment in PPE patients with a penile sympathetic skin response (PSSR). Of...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13076
更新日期:2018-11-01 00:00:00
abstract::The effect of gossypol--a polycyclic compound isolated from cotton seeds--on the plasminogen activator activity of man and ram acrosomal extracts was explored in vitro. The action of gossypol on the plasminogen activator activity was investigated by a spectrophotometric method using the chromogenic substrate S-2251. G...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1046/j.1439-0272.1999.00294.x
更新日期:1999-12-01 00:00:00
abstract::Sexual dysfunction is more prevalent in psychotic patients than in the nonpsychotic population. The objective of this study was to identify correlations between serum prolactin levels, testosterone levels and erectile dysfunction in patients with first-episode psychosis (n = 40) compared to age-matched healthy control...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13793
更新日期:2020-12-01 00:00:00
abstract::The effect of chronic chloroquine administration on prostaglandin E1 (PGE1) and human chorionic gonadotropin (hCG) stimulation of testosterone secretion by the rat Leydig cells was studied. Adult albino (Wistar strain) rats were injected with 4 mg/kg body weight of chloroquine phosphate every other day for 30 days. At...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1987.tb01900.x
更新日期:1987-09-01 00:00:00
abstract::Pre- and postdexamethasone triiodothyronine (T3), thyroxine (T4), and TSH levels of thirteen patients with psychogenic sexual dysfunction and thirteen controls were studied. Patients showed lowered T4 levels in comparison with the control group whereas T3 and TSH levels did not differ significantly. Dexamethasone had ...
journal_title:Andrologia
pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00
abstract::Neuropeptide Y (NPY) has been shown to induce contraction of isolated human penile erectile tissue and potentiate the response to noradrenaline. The purpose of our study was to measure in the cavernous and systemic blood of healthy male volunteers the course of NPY through different stages of sexual arousal. Whole blo...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.2011.01182.x
更新日期:2012-05-01 00:00:00
abstract::Incubation of human sperm from semen with counts below 20 x 10(6)/ml with peanut agglutinin (PNA) resulted in agglutination of about 70% of sperm. An inverse correlation was found between non-agglutinating (PNA) sperm and sperm density (r = 0.48, p less than 0.01) and a direct correlation with acrosome-damaged sperm (...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1990.tb01970.x
更新日期:1990-05-01 00:00:00
abstract::Previous studies have found that the ratio of estradiol to testosterone (E2/T ratio) has a negative effect on sexual function, but the relationship between the E2/T ratio and erection of the penis is not clarified. We conducted a retrospective study of 183 patients with erectile dysfunction and 52 healthy men to inves...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13701
更新日期:2020-10-01 00:00:00
abstract::Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a multifactorial problem affecting men of all ages and demographics. Currently, there is a relative dearth of epidemiological information on CPPS. It is clear that patients with CPPS have a dismal quality of life and many have benefited only minimally from ...
journal_title:Andrologia
pub_type: 杂志文章,评审
doi:10.1046/j.1439-0272.2003.00584.x
更新日期:2003-10-01 00:00:00
abstract::The influence of bacteria and/or leukocytes on the outcome of IVF or ICSI is influenced by three factors which have little in common with in vivo conditions: 1) The process of ejaculate preparation (swim-up, Percoll) with antibiotic buffered media; 2) The small amount of inseminated spermatozoa (100,000 per culture); ...
journal_title:Andrologia
pub_type: 杂志文章,评审
doi:10.1111/j.1439-0272.1998.tb02833.x
更新日期:1998-01-01 00:00:00
abstract::By means of specific RIA unconjugated 5 alpha-androstan-3 alpha, 17 beta-diol (3 alpha-diol) and 5 alpha-androstane-3 beta, 17 beta-diol (3 beta-diol) have been estimated for the first time in normal and pathological human seminal plasma. Testosterone, 5 alpha-dihydrotestosterone and testosterone-glucosiduronate (T, D...
journal_title:Andrologia
pub_type: 杂志文章
doi:
更新日期:1983-03-01 00:00:00
abstract::Men with hypertension often develop erectile dysfunction (ED). The present study aimed to examine the effects of sodium hydrosulphide (NaHS), a hydrogen (H2 S) donor, treatment on ED in nitric oxide synthase (NOS) inhibitor (L-NAME)-induced hypertensive rats. Forty adult Sprague-Dawley rats were divided into four grou...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13240
更新日期:2019-06-01 00:00:00