Identification of androgen receptor variants in testis from humans and other vertebrates.

Abstract:

:The androgen receptor (AR) is a ligand-activated transcription factor member of the nuclear receptor superfamily. The existence of alternatively spliced variants is well recognised for several members of this superfamily, most of them having functional importance. For example, several testicular oestrogen receptor variants have been suggested to play a role in the regulation of spermatogenesis. However, information on AR variants is mostly related to cancer and androgen insensitivity syndrome (AIS) cases. The objective of this study was to investigate the expression of AR variants in the testis from humans and other vertebrates. Four AR variants [ARΔ2(Stop) , ARΔ2(23Stop) , ARΔ3 and ARΔ4(120)] were identified in human testis. ARΔ2(Stop) and ARΔ3, with exon 2 or 3 deleted, respectively, were also expressed in human liver, lung, kidney and heart. In addition, ARΔ2(Stop) was expressed in rat and gilthead seabream testis, while an ARΔ3 was detected in African clawed frog testis. This is the first report revealing the existence of AR variants in the testis of evolutionarily distant vertebrate species and in nonpathological tissues. These data suggest the functional importance of these novel AR forms and demonstrate a complexity in AR signalling that is not exclusive of pathological conditions.

journal_name

Andrologia

journal_title

Andrologia

authors

Laurentino SS,Pinto PI,Tomás J,Cavaco JE,Sousa M,Barros A,Power DM,Canário AV,Socorro S

doi

10.1111/j.1439-0272.2012.01333.x

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

187-94

issue

3

eissn

0303-4569

issn

1439-0272

journal_volume

45

pub_type

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