Abstract:
:Reproductive dysfunction is one of the most prevalent diabetes complications. Draceana arborea is known to enhance sexual function in diabetic rats, but the underlying mechanisms have not been thoroughly elucidated. This study examined the effects of D. arborea on some reproductive complications of diabetes in rats. Aqueous and ethanol (500 and 100 mg/kg respectively) extracts of D. arborea, Sildenafil citrate (1.44 mg/kg), trimethylamine-N-oxide (TMAO, 20 mg/kg) and distilled water (10 ml/kg) were orally administered for 28 days to streptozotocin-induced diabetic rats. Glycaemia, body and reproductive organ masses, fertility parameters, total proteins, antioxidant enzymes activities, serum and testicular testosterone and the histology of the testes and epididymis were determined. Results revealed significant decreases in body and absolute and relative masses of testes, epididymis, seminal vesicles, prostate and vas deferens, fertility parameters, epididymal and testicular total proteins, serum and testicular testosterone levels as well as antioxidant enzymes activities. Interestingly, while having minor anti-hyperglycaemic effects, these abnormalities associated with testicular and epididymal alterations were alleviated by D. arborea especially the aqueous extract (500 mg/kg). These outcomes provided evidence of the androgenic properties of D. arborea in diabetic rats, which could be useful for a better management of sexual dysfunctions in diabetic patients.
journal_name
Andrologiajournal_title
Andrologiaauthors
Wankeu-Nya M,Watcho P,Deeh Defo PB,Ngadjui E,Nguelefack TB,Kamtchouing P,Kamanyi Adoi
10.1111/and.13381subject
Has Abstractpub_date
2019-11-01 00:00:00pages
e13381issue
10eissn
0303-4569issn
1439-0272journal_volume
51pub_type
杂志文章相关文献
ANDROLOGIA文献大全abstract::The present study was conducted to evaluate in vitro and in vivo antiproliferative potential of the Cameroonian propolis and to elucidate its underlying mechanism. In vitro, ethanol-extracted propolis (EEP) was tested on cell growth, cell proliferation, cell cycle, cell death mechanism and cell migration. The cell cyc...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13698
更新日期:2020-10-01 00:00:00
abstract::Approximately between 9 and 19 years of age 28 adolescents with one and 26 with both retractile testicles were andrologically examined and followed up. Retractile gonads during puberty often remained of subnormal size with the long axis shorter than 34 mm. In both groups in 50 to 60% of cases low sperm values were asc...
journal_title:Andrologia
pub_type: 杂志文章
doi:
更新日期:1988-09-01 00:00:00
abstract::Infertility occurs in up to 54% of men with bilateral undescended testes. Orchiectomy is considered the best therapeutic approach, especially when cryptorchidism is diagnosed in adulthood, due to a high risk of malignancy. A 33-year-old man was referred with a clinical presentation of empty scrotum and an ultrasonogra...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.12936
更新日期:2018-03-01 00:00:00
abstract::Sex hormones have been proposed as a possible risk factor for the development and growth of meningiomas. Hormonal therapy plays a fundamental role in the treatment of male-to-female transgenders and needs to be continued after sex reassignment surgery. Usually, this treatment leads to no adverse events; however, its i...
journal_title:Andrologia
pub_type: 杂志文章,评审
doi:10.1111/and.12550
更新日期:2016-12-01 00:00:00
abstract::Ran-binding protein 3 (RanBP3) is a Ran-interacting protein, which participates in the Ran GTPase system in cancer cell biology. However, the expression pattern and physiological role of RanBP3 remain largely unknown. In this study, we found that RanBP3 was expressed in human testes and localised to spermatogonium and...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13446
更新日期:2020-03-01 00:00:00
abstract::The aim of this study was to investigate the relationship between sulphur dioxide (SO2 ) signalling pathway and the changes in erectile function under low androgen levels. Thirty-six healthy male Sprague Dawley (SD) rats aged eight weeks were randomly divided into androgen replacement group, castration group and sham ...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13167
更新日期:2019-02-01 00:00:00
abstract::D-chloramphenicol, at concentrations of 20 and 40 micrograms/ml, inhibited over 80% of the newly synthesized mitochondrial proteins expressed by incorporation of 3H-amino acid mixture. At concentrations of 20 and 40 micrograms ml-1, D-chloramphenicol enhanced the collective motility of washed ram spermatozoa. The coll...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1994.tb00815.x
更新日期:1994-11-01 00:00:00
abstract::The effect of gossypol--a polycyclic compound isolated from cotton seeds--on the plasminogen activator activity of man and ram acrosomal extracts was explored in vitro. The action of gossypol on the plasminogen activator activity was investigated by a spectrophotometric method using the chromogenic substrate S-2251. G...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1046/j.1439-0272.1999.00294.x
更新日期:1999-12-01 00:00:00
abstract::The effect of 10 days i.m. treatment of testosterone propionate (TP) on plasma testosterone and accessory reproductive organs were studied in adult (6 to 6 1/2 kg) male rhesus monkeys, housed under natural light conditions using six different dose levels. The study was scheduled in the month of September and October. ...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1979.tb02237.x
更新日期:1979-01-01 00:00:00
abstract::There is a consensus on the diagnostic management of bacterial prostatitis (acute and chronic). In chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) the diagnostic approach remains unclear, because inflammatory and noninflammatory CP/CPPS might be one entity with varying findings over time. The WHO definition...
journal_title:Andrologia
pub_type: 杂志文章,评审
doi:10.1111/j.1439-0272.2007.00828.x
更新日期:2008-04-01 00:00:00
abstract::Cisplatin, a common chemotherapeutic drug, can induce testicular toxicity. Methylene blue, a potent antioxidant, can inhibit the generation of free radicals. This research aimed to study the protective effect of methylene blue against the cisplatin-induced toxicity of the reproductive system in rats. 35 male Wistar ra...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13850
更新日期:2021-02-01 00:00:00
abstract::Two esterases previously identified in seminal plasma, on the basis of their electrophoretic mobility, immunogenicity and sensitivity to organophosphorus esters were detected in various human external secretions and leucocyte extracts. alpha-Esterase was found to be abundant in urine and milk whereas this enzyme occur...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1976.tb01650.x
更新日期:1976-01-01 00:00:00
abstract::The purpose of our analysis is to identify the effect of l-carnitine (LC) and l-acetyl carnitine (LAC) on the semen parameters of men with idiopathic oligoasthenoteratozoospermia (iOAT). We performed a comprehensive search to ascertain all the trials about LC and LAC in the treatment of iOAT and compared the results, ...
journal_title:Andrologia
pub_type: 杂志文章,meta分析
doi:10.1111/and.13470
更新日期:2020-03-01 00:00:00
abstract::The aim of this study was to examine whether an association exists between glutathione S-transferase Mu-1 (GSTM1) gene polymorphism and idiopathic male infertility. Sixty men with primary idiopathic infertility and 60 fertile men, serving as controls, were recruited for the study. The polymorphism was analysed using p...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.12306
更新日期:2015-06-01 00:00:00
abstract::Primordial germ cells in the mouse are known to be derived from the epiblast. They can be identified histochemically, by their high alkaline phosphatase activity. At 8 d post coitum they have been observed within the embryonic part of the egg cylinder, at the posterior end of the primitive streak. Earlier, at 7.25 day...
journal_title:Andrologia
pub_type: 杂志文章,评审
doi:10.1111/j.1439-0272.1992.tb02647.x
更新日期:1992-09-01 00:00:00
abstract::Previous research has suggested an association between personality traits and coping, as well as between coping and sperm concentration. In the present study, both domains of research were combined, leading to the formulation of specific hypotheses. A total of 54 healthy volunteers were given questionnaires twice to a...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.2004.00647.x
更新日期:2005-02-01 00:00:00
abstract::Androgen insensitivity syndrome (AIS) is an X-linked disorder due to mutations of androgen receptor (AR) gene. Various AR mutations have been identified, and the characterisation of these mutations greatly facilitates our understanding of AR structure-function. In this study, we have analysed an AR missense mutation (...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.2011.01219.x
更新日期:2012-05-01 00:00:00
abstract::The incretory testicular function was tested in 21 patient with varicocele aged 19 to 39 years. In one group baseline testosterone was measured, while a second group received a single injection of 5000 IU HCG. Testosterone was studied in peripheral plasma in the spermatic vein and in testicular tissue. Baseline values...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1983.tb00179.x
更新日期:1983-11-01 00:00:00
abstract::This study investigated the hypothesis that genetic alterations of the human insulin-like 3 (INSL3) gene are associated with testicular maldescent (TMD). Genomic DNA was extracted and amplified from peripheral blood samples of 170 unrelated children with all possible phenotypical expressions of TMD and 50 volunteers w...
journal_title:Andrologia
pub_type: 杂志文章,评审
doi:10.1111/and.12184
更新日期:2014-01-01 00:00:00
abstract::Using a highly sensitive radioimmunoassay (RIA) of estramustine binding protein (EMBP) with the antibody raised against rat-EMBP, the concentration of EMBP in human benign prostatic hypertrophy (BPH) tissue was evaluated. Using mechanical separation procedure, EMBP was found significantly higher in the epithelium (10....
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1990.tb01990.x
更新日期:1990-07-01 00:00:00
abstract::The aim of this study was to compare the effectiveness of antioxidants including cysteamine (2.5, 7.5 mm), hyaluronan (0.25, 1 mg ml(-1) ) and fetuin (5, 10 mg ml(-1) ) in the freezing of Brown Swiss bull semen. The best percentages of CASA motilities were achieved with 10 mg ml(-1) of fetuin and 2.5 mm of cysteamine....
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.12236
更新日期:2015-03-01 00:00:00
abstract::The suggested concept of "bone as an endocrine organ" had shed the light on the role of osteocalcin, an osteoblast secreted hormone, in regulation of testosterone production. This study aimed to assess the association between the active undercarboxylated form of osteocalcin (ucOC) and semen parameters and hormonal lev...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.12755
更新日期:2017-11-01 00:00:00
abstract::We examined whether men with anabolic-steroid-induced hypogonadism (ASIH) seeking testosterone supplementation therapy (TST) regretted their decision to use anabolic-androgenic steroids (AAS) and what their reasons were for this regret. An anonymous, prospective survey was distributed to 382 men seeking follow-up trea...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.12340
更新日期:2015-10-01 00:00:00
abstract::Semen samples of 24 patients were analysed. Volumes were measured and the numbers of progressively motile (PMS), motile (MS) and nonmotile spermatozoa (NMS) were determined. These 24 samples appeared to show a large variation in motility percentages and numbers. Spermatozoa of these semen samples were isolated from th...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1046/j.1439-0272.2001.00430.x
更新日期:2001-05-01 00:00:00
abstract::There is growing concern that abnormalities in male reproductive health are becoming more frequent. The most fundamental change has been the striking decline in sperm counts and semen quality. The effect of maternal exposure of rats to the oestrogenic environmental substance p-nonylphenol (p-NP) was determined in this...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1046/j.1439-0272.1999.00246.x
更新日期:1999-03-01 00:00:00
abstract::The purpose of this study was to explore the value of two-dimensional ShearWave™ Elastography (2D-SWE) on quantitatively evaluating the change of the content of collagen fibres in penis. Twenty male Sprague Dawley rats were divided into the pre-sexual maturity group (Group 1) and the sexual decline group (Group 2) acc...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.12653
更新日期:2017-06-01 00:00:00
abstract::Sperm cell plasma membrane and the outer acrosomal membrane fuse profusely during the acrosome reaction. The process is triggered by extracellular signals that elicit several intracellular events leading ultimately to membrane fusion. We have developed a streptolysin O permeabilizing protocol that selectively affects ...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1996.tb02753.x
更新日期:1996-01-01 00:00:00
abstract::The simultaneous swimming up and down from identical semen specimens suggested that the separation efficiency of progressively motile sperm by the swim-down method was superior to that of the swim-up method. The swimming down was performed in a small plastic funnel, the bottom of which was plugged with a 2.5 ml dispos...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1991.tb02485.x
更新日期:1991-01-01 00:00:00
abstract::Male fertility preservation has been steadily increasing over the past two decades. Significant improvements have been achieved in the treatment modalities of cancer and other severe chronic medical conditions, leading to an increase in patient survivorship and the resulting demand for future parenthood. Recognition a...
journal_title:Andrologia
pub_type: 杂志文章,评审
doi:10.1111/and.13635
更新日期:2020-05-11 00:00:00
abstract::The techniques of SDS-polyacrylamide slab gel electrophoresis and a sensitive fluorescamine-based method were used to study autoproteolysis of human seminal coagulum at various pH. The major protein bands of 72 and 55 Kd were optimally degraded at pH 7.5. Degradation at pH 3.5 was preceded by a lag period of 30 min. W...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1986.tb01771.x
更新日期:1986-05-01 00:00:00