Abstract:
:Primordial germ cells in the mouse are known to be derived from the epiblast. They can be identified histochemically, by their high alkaline phosphatase activity. At 8 d post coitum they have been observed within the embryonic part of the egg cylinder, at the posterior end of the primitive streak. Earlier, at 7.25 days post coitum, we have observed them embedded in the extra-embryonic mesoderm, as a tight clump. Germ cell counts over the 7-8 d period of gastrulation have been made. They are consistent with either of two models: (1) derivation of the germ cell lineage from a very small stem cell pool, followed by a constant rate of proliferation, and (2) derivation from a larger initial stem cell pool, followed by a period when germ cells are differentiating but not dividing. From their initial extra-embryonic location, germ cells spread into the mesoderm of the primitive streak, and the endoderm of the yolk sac and hind gut. Active locomotion is probably required for their passage up the dorsal mesentery and into the genital ridges. Mutant alleles at two loci, W (White-spotting) and Sl (Steel), drastically reduce the number of germ cells reaching the ridges. Since those that succeed in reaching the ridges suffer little if any delay, the defect is unlikely to be due to reduced powers of locomotion, but rather to a failure of proliferation or survival. W acts cell-autonomously: its gene product is the c-kit polypeptide, a transmembrane tyrosine kinase receptor.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Andrologiajournal_title
Andrologiaauthors
McLaren Adoi
10.1111/j.1439-0272.1992.tb02647.xkeywords:
subject
Has Abstractpub_date
1992-09-01 00:00:00pages
243-7issue
5eissn
0303-4569issn
1439-0272journal_volume
24pub_type
杂志文章,评审相关文献
ANDROLOGIA文献大全abstract::The aim of this study was to investigate the predictive value of the parameters that might have an effect on the success of microscopic testicular sperm extraction (micro-TESE) in infertile patients with nonobstructive azoospermia (NOA). Between 2003 and 2014, 860 patients with NOA were retrospectively analysed. The e...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13441
更新日期:2019-12-01 00:00:00
abstract::By means of specific RIA unconjugated 5 alpha-androstan-3 alpha, 17 beta-diol (3 alpha-diol) and 5 alpha-androstane-3 beta, 17 beta-diol (3 beta-diol) have been estimated for the first time in normal and pathological human seminal plasma. Testosterone, 5 alpha-dihydrotestosterone and testosterone-glucosiduronate (T, D...
journal_title:Andrologia
pub_type: 杂志文章
doi:
更新日期:1983-03-01 00:00:00
abstract::The role of N-methyl-D-aspartate (NMDA) and non-NMDA receptors in the control of FSH and LH secretion was analysed in prepubertal male rats. In the first experiment 4, 8, 12, 16, 20 and 30-day-old males were decapitated 15 min after vehicle, NMDA or kainic acid (KA) administration. In the second experiment, 23-day-old...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1996.tb02776.x
更新日期:1996-05-01 00:00:00
abstract::There is a consensus on the diagnostic management of bacterial prostatitis (acute and chronic). In chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) the diagnostic approach remains unclear, because inflammatory and noninflammatory CP/CPPS might be one entity with varying findings over time. The WHO definition...
journal_title:Andrologia
pub_type: 杂志文章,评审
doi:10.1111/j.1439-0272.2007.00828.x
更新日期:2008-04-01 00:00:00
abstract::Epidermal growth factor concentrations and amounts per ejaculate were determined in 162 infertile men and in a control group of 50 pregnancy-proven fertile men. No differences were found between those groups. The group of infertile patients was divided into sub-groups according to their sperm density. EGF values in th...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1991.tb02549.x
更新日期:1991-05-01 00:00:00
abstract::The aim of this study was to evaluate the production of artefacts during preparation and observation of human sperm for ultrastructural morphology and analyse the possible reasons of causing these artefacts. Under the scanning electron microscopy, damaged sperm heads (crack or/and rupture), necks (head-neck or head-mi...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13043
更新日期:2018-09-01 00:00:00
abstract::The aim of this study was to access whether microsurgical subinguinal varicocelectomy (MSV) with testicular delivery has a better therapeutic effect than MSV without testicular delivery, including semen quality, serum testosterone (T) level and International Index of Erectile Function (IIEF)-5 score in infertility mal...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13605
更新日期:2020-07-01 00:00:00
abstract::This prospective study was performed to evaluate the relationship between interleukin-6 (IL-6), oxidative stress and sperm function following vasectomy reversal. We included 22 patients who underwent vasectomy reversal and 15 healthy sperm donors (controls) with normal sperm morphology criteria. Levels of IL-6 in the ...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.2005.00668.x
更新日期:2005-08-01 00:00:00
abstract::The prime concern of the present work was the analysis of dermatoglyphic patterns in infertile patients presenting with clinically detectable varicocele. In a controlled study conducted on 30 patients and utilizing a slight modification of the original ink method of Cummins and Midlo, the dermatoglyphics on terminal p...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1984.tb00244.x
更新日期:1984-03-01 00:00:00
abstract::Maturation arrest (MA) of spermatogenesis is diagnosed on histology as interruption of spermatogenesis before the final stage without impairment of Sertoli or Leydig cells. It is considered a condition of irreversible or absolute infertility. Varicocele, which represents impairment in the testicular venous drainage sy...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.2010.01083.x
更新日期:2010-12-01 00:00:00
abstract::MAGI is the inflammation of the accessory male glands that notoriously exerts a negative influence on male fertility. The diagnosis is integrated by clinical, laboratory and ultrasound evaluation. In particular, the ultrasound criteria were published in 1999. The aim of this study was to analyse the sensitivity and sp...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.2010.01132.x
更新日期:2012-05-01 00:00:00
abstract::By means of a recently developed apparatus ("Separon") motile spermatozoa were concentrated in a small volume of culture medium (0,3 ml). Sperm concentration, progressive motility and mean velocity of 60 ejaculates were determined by a computerized videomicrography system. After "Separon" sperm concentration was reduc...
journal_title:Andrologia
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
abstract::The aim of this study was to evaluate the effect of Lepidium meyenii (maca) in chemically and physically subfertile mice. After 35 days, the following groups of mice were evaluated: control, sham, chemical subfertility, chemical subfertility-maca-supplemented, physical subfertility, physical subfertility-maca-suppleme...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.12682
更新日期:2016-10-01 00:00:00
abstract::Between 1994 and 2010, a total of 123 patients with obstructive azoospermia due to aplasia of vas deferens (CAVD) were surgically treated. In 110 patients, the condition was bilateral (CBAVD), 13 men had unilateral aplasia (CUAVD), and 10 patients additionally had aplasia of one kidney. All patients underwent CFTR gen...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.2012.01281.x
更新日期:2012-10-01 00:00:00
abstract::Serum prolactin concentration, measured by radioimmunoassay, was significantly higher (p less than 0.005) in 49 patients with impotence than in a control population of 16 normal subjects. 26.5% of the impotent patients had hyperprolactinemia. Their serum testosterone was also significantly lower (p less than 0.05). Br...
journal_title:Andrologia
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract::The sperm function of fertile men (control), infertility patients (experimental), and men with varicocele were compared. The bioassays used were the follicular fluid-induced acrosome reaction, the binding to the zona pellucida, and the penetration of zona-free hamster oocytes. The percentage (mean +/- SEM) of reacted ...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1994.tb00756.x
更新日期:1994-03-01 00:00:00
abstract::A global increase in the incidence of subfertility is observed, and research suggests strong genetic influences that might restrict fertility directly or indirectly. It therefore becomes important to rule out the existence of genetic causes and counsel infertile couples before offering "Advanced Infertility Treatment ...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13434
更新日期:2019-11-01 00:00:00
abstract::The adult human Sertoli cells produced lactate, estradiol-17beta, transferrin and inhibin; germ cells modulate synthesis of these compounds. In order to study the functional features of human Sertoli cells in vitro, the aim of this study was to measure the lactic dehydrogenase (LDH), gamma-glutamyl transpeptidase (GGT...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1996.tb02762.x
更新日期:1996-03-01 00:00:00
abstract::The Aurora kinases regulate chromosome segregation and cytokinesis, and alterations in their expression associate with cell malignant transformation. In this study, we demonstrated by qRT-PCR analysis of 14 seminomas that Aurora-A mRNA was, with respect to control tissues, augmented in five of 14 tumour tissues by 2.1...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.2009.00987.x
更新日期:2010-08-01 00:00:00
abstract::The aim of this study was to examine whether an association exists between glutathione S-transferase Mu-1 (GSTM1) gene polymorphism and idiopathic male infertility. Sixty men with primary idiopathic infertility and 60 fertile men, serving as controls, were recruited for the study. The polymorphism was analysed using p...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.12306
更新日期:2015-06-01 00:00:00
abstract::Epididymal sperm reserve was determined in 6 sexually mature fertile buffalo-bulls having normal process of spermatogenesis. The relative distribution of spermatozoa in the caput, corpus and cauda epididymidis averaged 5.42, 0.75 and 11.45 billion respectively. Total epididymal sperm reserve per bull averaged 36.2 bil...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1978.tb03076.x
更新日期:1978-11-01 00:00:00
abstract::In mice, chronic administration of crude marihuana extract (CME), delta-9-tetrahydrocannabinol (THC), cannabidiol (CBD) and cannabinol (CBN) (50 mg kg-1 body weight for 15 and 35 days) impaired spermatogenesis at both mitotic and meiotic stages. Although the total number of step 7 spermatids was unaltered, mature sper...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1991.tb02520.x
更新日期:1991-03-01 00:00:00
abstract::Nonsomatic factors play a significant role in erectile dysfunction. We assessed the impact on men suffering from male factor infertility by employing the validated Self-Esteem and Relationship questionnaire (SEAR) and compared the scores with controls. Men with primary infertility were asked to fill SEAR questionnaire...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13460
更新日期:2020-03-01 00:00:00
abstract::One prerequisite for fertilization is the specific binding of spermatozoa to the zona pellucida. However, the factors and mechanisms involved in this gamete contact are not well understood. Gamete recognition and binding are species-specific and are controlled by oligosaccharides of the zona and their corresponding ca...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1046/j.1439-0272.2001.00412.x
更新日期:2001-09-01 00:00:00
abstract::The acrosome is a secretory vesicle located in the sperm head. The acrosome reaction consists in the fusion of the sperm plasma membrane with the external acrosomal membrane. It has been observed that this reaction does not take place in spermatozoa incubated in cervical mucus, hydrogel that contains high concentratio...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.2007.00814.x
更新日期:2008-06-01 00:00:00
abstract::This study was aimed at determining the effects of corn and wheat gluten, used as dietary protein sources, on live weight gain, sperm quality and the histology of the testes and accessory glands in male rats. For this purpose, 20-day-old 24 male Wistar albino rats were randomly assigned to three groups. Group 1 (Contr...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13601
更新日期:2020-07-01 00:00:00
abstract::Human chorionic Gonadotropin (HCG) therapy has been used beneficially in men with subfertility especially after varicocele surgery. Very few side effects have been observed in male patients. Herein, we report a case of pulmonary embolism in a male patient following the use of HCG. The patient was subsequently found to...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1987.tb01861.x
更新日期:1987-01-01 00:00:00
abstract::Intermittent hypobaric hypoxia (IHH) induced a decrease in sperm count and oxidative damage in epididymis. We have previously demonstrated that a blueberry-enriched polyphenol extract (BB-4) reduced the adverse effects of oxidative stress in rat testis under hypobaric hypoxia. The aim of this study was to evaluate whe...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.12146
更新日期:2014-09-01 00:00:00
abstract::The dicentric Y chromosome is the most common cytogenetically visible structural abnormality of Y chromosome. The sites of break and fusion of dicentric Y are variable, but break and fusion at Yq12 (proximal to the pseudoautosomal region 2/PAR 2) is very rare. Dicentric Y chromosome is unstable during cell division an...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.12886
更新日期:2018-03-01 00:00:00
abstract::The purpose of this study was to explore the value of two-dimensional ShearWave™ Elastography (2D-SWE) on quantitatively evaluating the change of the content of collagen fibres in penis. Twenty male Sprague Dawley rats were divided into the pre-sexual maturity group (Group 1) and the sexual decline group (Group 2) acc...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.12653
更新日期:2017-06-01 00:00:00