Abstract:
:CAG trinucleotide repeats are coded for the polyglutamine tract in the N-terminal of the androgen receptor (AR) gene which varies in normal individuals from 6 to 36 residues. In this study, we inspected the impact of the CAG repeats on the spermatogenic defects by measuring the size of AR-CAG repeats length in a cohort of 260infertile and 169 fertile Jordanian men. The infertile group included three subgroups of a zoospermic, oligozoospermic and teratozoospermia men. The CAG allele size was determined by direct sequencing. The results showed a significant association between the length of the AR-CAG repeats and men's infertility (p = .001). In particular, the current cohort demonstrated a significant association between the AR-CAG length polymorphism and oligozoospermia (p < .001) and teratozoospermia (p < .001) but not azoospermia. According to distributions of allele frequency, the risk of oligozoospermia was 5.5-fold greater than normal when alleles frequency > 20 repeats, while the risk of teratozoospermia was > 10.6 folds greater than normal when allele frequency > 22 repeats. In conclusion, our results underscored that the long repeats of the AR-CAG polymorphism within the normal range might be associated with abnormal spermatogenesis such as teratozoospermia and oligozoospermia and contributing to infertility in Jordanian men.
journal_name
Andrologiajournal_title
Andrologiaauthors
Al Zoubi MS,Bataineh H,Rashed M,Al-Trad B,Aljabali AAA,Al-Zoubi RM,Al Hamad M,Issam AbuAlArjah M,Batiha O,Al-Batayneh KMdoi
10.1111/and.13728subject
Has Abstractpub_date
2020-10-01 00:00:00pages
e13728issue
9eissn
0303-4569issn
1439-0272journal_volume
52pub_type
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