Prevalence of carcinoma in situ in testicular biopsies of infertile Iranian men.

Abstract:

:Almost all testicular germ cell tumours are proved to originate from carcinoma in situ cells. Infertility is one of the factors that increase the risk of carcinoma in situ. The reported prevalence for carcinoma in situ from different parts of the world is 0-3.7% in infertile men. This retrospective study was performed to determine the prevalence of carcinoma in situ in Iranian infertile men. We reviewed the testicular biopsies of 1153 infertile men at the pathology department of Avicenna Infertility Center. One hundred and fifty-one cases were suspicious of having carcinoma in situ. Immunohistochemical marker for placental alkaline phosphatase was employed to confirm the diagnosis of carcinoma in situ. Positive results were detected in 7 (0.6%) of 1153 cases (95% CI 0.24%-1.24%), 6 (0.94%) of which (95% CI 0.34%-2.04%) were under the age of 35 years (636 patients were in this age group). This study is the first study in Iran determining the prevalence of carcinoma in situ among the infertile Iranian men; the result is in the range of reports from other countries.

journal_name

Andrologia

journal_title

Andrologia

authors

Soltanghoraee H,Pourkeramati F,Khoddami M,Amirjannati N,Akhondi MM,Soltani A

doi

10.1111/and.12139

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

726-30

issue

7

eissn

0303-4569

issn

1439-0272

journal_volume

46

pub_type

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