Abstract:
:In order to investigate the role of testosterone propionate (TP) on the antioxidant system of the rat testis, lipid peroxidation (LPX) and activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) of the testis of testosterone-treated and control rats were compared. The results indicate that TP administration to intact adult rats resulted in a significant decline in protein content of various subcellular fractions. This is accompanied with significant elevation in LPX levels of various subcellular fractions suggesting induction of oxidative stress. Activities of three enzymes related to the metabolism of superoxide radical (SOD) and hydrogen peroxide (CAT and GPx) of testis, were found to be significantly decreased in response to TP treatment. The role of testosterone in regulating testicular spermatogenesis through oxidative stress is discussed.
journal_name
Andrologiajournal_title
Andrologiaauthors
Chainy GB,Samantaray S,Samanta Ldoi
10.1111/j.1439-0272.1997.tb00328.xsubject
Has Abstractpub_date
1997-11-01 00:00:00pages
343-9issue
6eissn
0303-4569issn
1439-0272journal_volume
29pub_type
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