Kisspeptin and RF9 prevent paroxetine-induced changes in some parameters of seminal vesicle fluid in the male rats.


:The aim of the study was to examine possible impacts of paroxetine and agomelatine on the levels of some components that constitute the seminal vesicle fluid. As a second purpose, it was also aimed to examine how possible negative effects induced by paroxetine on seminal vesicle fluid components were affected by kisspeptin and RF9 (an RFamide-related peptide antagonist, RFRP). Forty-two male rats, aged 21 days, divided into six groups; control, sham, paroxetine, agomelatine, paroxetine + kisspeptin and paroxetine + RF9. Paroxetine (3.6 mg/kg) and agomelatine (10 mg/kg) were administrated by oral gavage. Kisspeptin (1 nmol) and RF9 (20 nmol) were administered intracerebroventricular (i.c.v). The experiments were ended on post-natal 120 days; fructose, vitamin E, sodium, potassium and magnesium levels were measured in seminal vesicle fluid. Fructose, vitamin E, magnesium and potassium levels were significantly decreased in seminal vesicle fluid from the rats treated with paroxetine but did not show significant differences following agomelatine administration. The co-administration of kisspeptin or RF9 with paroxetine prevented the paroxetine-induced negative effects on seminal vesicle fluid components. These results suggest that reduction in sperm fertilising ability caused by changes in seminal vesicle fluid can be seen in long-term antidepressant use. RF-9 and kisspeptin might have positive effects on long-term antidepressant use-induced infertility.






Gulcu Bulmus F,Canpolat S,Sahin Z,Bulmus O,Serhatlioglu I,Kelestimur H




Has Abstract


2020-05-01 00:00:00












  • [Use of the ultrasonic Doppler stethoscope in the diagnosis of varicocele].

    abstract::In cases of varicocele the reverse venous blood flow can be detected by the use of the Doppler-stethoscope in a simple way. Applied to the basic examination of fertility patients this method has proved to be a valuable non-invasive screening in the evaluation of varicoceles including cases with minor clinical symptoms...


    pub_type: 杂志文章


    authors: Ebert L,Bedbur M,Hofmann N

    更新日期:1980-09-01 00:00:00

  • Male reproductive health: cause for concern?

    abstract::A substantial body of evidence has accumulated in recent years that human semen quality may be deteriorating. This has been associated with evidence of other changes in male reproductive health, including increases in congenital malformations and testicular cancer in humans, and similar problems in wildlife. Unfortuna...


    pub_type: 杂志文章,评审


    authors: Irvine DS

    更新日期:2000-09-01 00:00:00

  • Experience with the Jonas penile prosthesis in the treatment of impotence.

    abstract::The penile prosthesis has become established as a mode of therapy for organic and chronic psychogenic impotence. The Jonas type of penile prosthesis has been implanted into 10 patients and has achieved both functional success and excellent acceptance by the partner. Mechanical and pathological complications have a ver...


    pub_type: 杂志文章


    authors: Reisner GS,Lording DW,Rose N

    更新日期:1984-05-01 00:00:00

  • Chloroquine excretion in semen following antimalarial-drug administration.

    abstract::The study described here was carried out to establish whether or not chloroquine was excreted in semen. Chloroquine was assayed in the semen of eight male volunteers (aged between 19 and 45 years) by a fluorimetric method before and after taking a total dose of 1.500 mg chloroquine base corresponding to the accepted d...


    pub_type: 杂志文章


    authors: Adeeko AO,Dada OA

    更新日期:1994-05-01 00:00:00

  • Effects of oestrogen-induced hyperprolactinemia on the rat prostate.

    abstract::Exposure of intact rats to increasing doses of oestradiol-17 beta in the presence of a constant amount of exogenous androgen caused a dose-related increase in the concentration of zinc in the lateral lobes and a decrease in the levels of ventral lobe prolactin binding. These changes occurred concomitantly with a dose-...


    pub_type: 杂志文章


    authors: Oldereid NB,Thomassen Y,Rui H,Gordeladze JO,Haug E,Purvis K

    更新日期:1986-09-01 00:00:00

  • Hypotonic challenge reduces human sperm motility through coiling and folding of the tail.

    abstract::Human ejaculates collected for in vitro procedures show variably rapid increases in osmolality, depending on enzymatic degradation of compounds. Changes in osmolality can affect cell functions due to the energy consuming processes needed to control cell volume. The aim was to examine the effects of a hypotonic challen...


    pub_type: 杂志文章


    authors: Holmes E,Björndahl L,Kvist U

    更新日期:2020-12-01 00:00:00

  • Oestrogen receptors beta genotype in infertile Egyptian men with nonobstructive azoospermia.

    abstract::In a prospective study, the polymorphism of oestrogen receptor β gene was investigated in nonobstructive azoospermia patients. Ninety infertile patients with nonobstructive azoospermia diagnosed after two semen analysis, 2 weeks apart and negative testicular sperm extraction during intracytoplasmic sperm injection, an...


    pub_type: 杂志文章


    authors: Younes AH,Hamed HB,Mohamed EM,Makki MA,Gaber N,Mohamed HM

    更新日期:2016-12-01 00:00:00

  • Testicular sperm extraction after laparoscopic orchiectomy for bilateral postpubertal intra-abdominal cryptorchidism: What chance of sperm retrieval?

    abstract::Infertility occurs in up to 54% of men with bilateral undescended testes. Orchiectomy is considered the best therapeutic approach, especially when cryptorchidism is diagnosed in adulthood, due to a high risk of malignancy. A 33-year-old man was referred with a clinical presentation of empty scrotum and an ultrasonogra...


    pub_type: 杂志文章


    authors: Cito G,Della Camera PA,Degli Innocenti S,Coccia ME,Nesi G,Cocci A,Morselli S,Minervini A,Carini M,Serni M,Gacci M,Natali A

    更新日期:2018-03-01 00:00:00

  • [Change in sodium and potassium concentration in human seminal plasma infected experimentally with Ureaplasma urealyticum].

    abstract::The concentration of sodium and potassium ions was measured by flame photometry in human seminal plasma and human sperm cells as well as in a sperm cell suspension infected experimentally with Ureaplasma urealyticum during incubation as long as 22 hours. The sodium concentration is 86.2 +/- 21.97 mmol/l cells in sperm...


    pub_type: 杂志文章


    authors: Mehl M,Petzoldt R,Engel S,Bollmann R,Köhler W

    更新日期:1986-03-01 00:00:00

  • Mast cells in testicular biopsies of infertile men with 'mixed atrophy' of seminiferous tubules.

    abstract::Mast cells in the bilateral testicular biopsies of 30 patients with a 'mixed atrophy' of seminiferous tubules were analysed. Seven biopsies from vasectomized patients served as controls. With regard to their characteristic location within testicular tissue, two groups of mast cells could be distinguished, in both cont...


    pub_type: 杂志文章


    authors: Jezek D,Banek L,Hittmair A,Pezerović-Panijan R,Goluza T,Schulze W

    更新日期:1999-07-01 00:00:00

  • Terazosin-induced alterations in catalase expression and lipid peroxidation in the rat seminal vesicles.

    abstract::Previous studies have shown that alpha1-adrenergic receptor antagonists may alter seminal vesicle contractility and impair fertility in male rats. This study was designed to investigate the effects of terazosin on the catalase expression in the seminal vesicles and the lipid peroxidation of the seminal fluid in normal...


    pub_type: 杂志文章


    authors: Mitropoulos D,Patris E,Deliconstantinos G,Kyroudi-Voulgari A,Anastasiou I,Perea D

    更新日期:2013-04-01 00:00:00

  • The effects of different dietary protein sources on live weight, sperm quality and the histology of the testes and accessory glands in male rats.

    abstract::This study was aimed at determining the effects of corn and wheat gluten, used as dietary protein sources, on live weight gain, sperm quality and the histology of the testes and accessory glands in male rats. For this purpose, 20-day-old 24 male Wistar albino rats were randomly assigned to three groups. Group 1 (Contr...


    pub_type: 杂志文章


    authors: Gumus R,Uslu S,Uslu BA

    更新日期:2020-07-01 00:00:00

  • Enzymatic properties of adult human Sertoli cells in vitro.

    abstract::The adult human Sertoli cells produced lactate, estradiol-17beta, transferrin and inhibin; germ cells modulate synthesis of these compounds. In order to study the functional features of human Sertoli cells in vitro, the aim of this study was to measure the lactic dehydrogenase (LDH), gamma-glutamyl transpeptidase (GGT...


    pub_type: 杂志文章


    authors: Carreau S,Drosdowsky MA,Foucault P

    更新日期:1996-03-01 00:00:00

  • Effects of indoor air purification by an air cleaning system (Koala technology) on semen parameters in male factor infertility: results of a pilot study.

    abstract::A number of studies indicated a clear decline in semen quality in the past 30-50 years and there is accumulating evidence that this decline might result from exposure to high levels of air pollution. To examine the impact of environment on male reproductive ability, we undertook for the first time a pilot study on sem...


    pub_type: 杂志文章


    authors: Paradisi R,Vanella S,Barzanti R,Cani C,Battaglia C,Seracchioli R,Venturoli S

    更新日期:2009-06-01 00:00:00

  • Unconjugated 5 alpha-androstan-3 alpha, 17 beta-diol and 5 alpha-androstane-3 beta, 17 beta-diol in normal and pathological human seminal plasma. Comparison with testosterone, 5 alpha-dihydrotestosterone and testosterone-glucosiduronate.

    abstract::By means of specific RIA unconjugated 5 alpha-androstan-3 alpha, 17 beta-diol (3 alpha-diol) and 5 alpha-androstane-3 beta, 17 beta-diol (3 beta-diol) have been estimated for the first time in normal and pathological human seminal plasma. Testosterone, 5 alpha-dihydrotestosterone and testosterone-glucosiduronate (T, D...


    pub_type: 杂志文章


    authors: Kurniawan E,Tamm J,Volkwein U,Schirren C

    更新日期:1983-03-01 00:00:00

  • Efficacy and safety of testosterone replacement gel for treating hypogonadism in men: Phase III open-label studies.

    abstract::Efficacy and safety of testosterone gel 2% (TG) were evaluated in two phase 3, open-labelled, single-arm, multicentre studies (000023 and extension study 000077). Hypogonadal men having serum testosterone levels <300 ng/dl at two consecutive measurements were included. Study duration was 9 months (000023: 3 months; 00...


    pub_type: 杂志文章,多中心研究


    authors: Belkoff L,Brock G,Carrara D,Neijber A,Ando M,Mitchel J

    更新日期:2018-02-01 00:00:00

  • Germ cell apoptosis induced by experimental cryptorchidism is mediated by molecular pathways in mouse testis.

    abstract::The aim of the study was to characterise the alterations in expression of some apoptosis regulators in unilaterally and bilaterally heat-treated mouse testes at different time intervals to 42 days after surgery. Cryptorchidism was induced in immature mice by returning the testis to the abdominal cavity via a surgical ...


    pub_type: 杂志文章


    authors: Absalan F,Movahedin M,Mowla SJ

    更新日期:2010-02-01 00:00:00

  • Reproductive immunology: 4. The effect of seminal plasma from immunologic infertile men on in vitro lymphocyte cultures.

    abstract::The seminal plasma of 31 patients were examined for the presence of sperm antibodies and for inhibitory properties on the transformation rates of donor lymphocytes cultured in vitro. Twenty five (80%) of the men revealed apart from fertile semen, no sperm antibody activities while six (20%) patients showed high sperma...


    pub_type: 杂志文章


    authors: Franken DR,Slabber CF

    更新日期:1982-03-01 00:00:00

  • Evaluation of various doses of testosterone on accessory reproductive organs and plasma testosterone in intact and gonadectomized rhesus monkeys (Macaca mulatta).

    abstract::The effect of 10 days i.m. treatment of testosterone propionate (TP) on plasma testosterone and accessory reproductive organs were studied in adult (6 to 6 1/2 kg) male rhesus monkeys, housed under natural light conditions using six different dose levels. The study was scheduled in the month of September and October. ...


    pub_type: 杂志文章


    authors: Mangat HK

    更新日期:1979-01-01 00:00:00

  • Leptin exists in tubuli seminiferi and in seminal plasma.

    abstract::Leptin is a 167-amino acid protein that stimulates gonadotrophin-releasing hormone secretion and exerts indirect effects on the gonads via neuropeptide Y, NPY. Recent research has suggested that leptin may also have an effect on testosterone secretion. To investigate the role of leptin in reproduction, leptin in testi...


    pub_type: 杂志文章


    authors: Glander HJ,Lammert A,Paasch U,Glasow A,Kratzsch J

    更新日期:2002-09-01 00:00:00

  • The Fas system in the seminiferous epithelium and its possible extra-testicular role.

    abstract::The Fas system is involved in the control of immune system homeostasis and nonfunctional Fas system leads to autoimmune disease in mice and humans. The Fas system is a mechanism through which cells expressing Fas ligand (FasL) induce apoptosis of Fas expressing cells. In mouse and rat, the testis represents the main s...


    pub_type: 杂志文章,评审


    authors: Riccioli A,Salvati L,D'Alessio A,Starace D,Giampietri C,De Cesaris P,Filippini A,Ziparo E

    更新日期:2003-02-01 00:00:00

  • Nasturtium Officinale L. hydroalcoholic extract improved oxymetholone-induced oxidative injury in mouse testis and sperm parameters.

    abstract::Testicular tissue and sex hormones are sensitive to the anabolic steroids (oxymetholone/OM) due to increased free radical damage and hormonal changes. The Nasturtium officinale L. have various antioxidant compounds. The aim of the present study was to investigate N. officinale effect on OM-induced oxidative injury in ...


    pub_type: 杂志文章


    authors: Akbari Bazm M,Khazaei M,Khazaei F,Naseri L

    更新日期:2019-08-01 00:00:00

  • Effect of tadalafil and 3-hydroxy-3-methylglutaryl coenzyme A inhibitor statin on the haemodynamics of cavernous and brachial arteries.

    abstract::Erectile dysfunction (ED) is usually associated with cardiovascular disease and reduced endothelial function. The aim of the present study was to examine the effect of tadalafil and statin on the endothelial function of cavernous and brachial arteries in healthy men and in patients with ED. The cases included in the s...


    pub_type: 杂志文章


    authors: Simsek A,Ozbek E,Oncu M

    更新日期:2014-09-01 00:00:00

  • Antiapoptotic effects of dehydroepiandrosterone on testicular torsion/detorsion in rats.

    abstract::In the present study, we aimed to evaluate the effects of dehydroepiandrosterone (DHEA) on apoptosis of testicular germ cells after repair of testicular torsion in rats. Twenty-four adult male Sprague-Dawley rats were randomly divided into four groups, with six rats in each group: sham operation, torsion/detorsion (T/...


    pub_type: 杂志文章


    authors: Yapanoglu T,Aksoy Y,Gursan N,Ozbey I,Ziypak T,Calik M

    更新日期:2008-02-01 00:00:00

  • Effects of a DNA-specific fluorochrome, Hoechst 33258, on mouse sperm motility and fertilizing capacity.

    abstract::DNA specific fluorochrome (Hoechst 33342 and 33258) as non-toxic stains, have been widely used to measure cell density and proliferation, detect sperm-egg fusion, and observe the development of pre-implantation embryos. It has been reported that Hoechst 33342 at a concentration of 10 micrograms ml-1 had significant in...


    pub_type: 杂志文章


    authors: Yelian FD,Dukelow WR

    更新日期:1992-05-01 00:00:00

  • Effect of Lepidium meyenii (maca) on testicular function of mice with chemically and physically induced subfertility.

    abstract::The aim of this study was to evaluate the effect of Lepidium meyenii (maca) in chemically and physically subfertile mice. After 35 days, the following groups of mice were evaluated: control, sham, chemical subfertility, chemical subfertility-maca-supplemented, physical subfertility, physical subfertility-maca-suppleme...


    pub_type: 杂志文章


    authors: Valdivia Cuya M,Yarasca De La Vega K,Lévano Sánchez G,Vásquez Cavero J,Temoche García H,Torres Torres L,Cruz Ornetta V

    更新日期:2016-10-01 00:00:00

  • An immunohistochemical study for testicular biopsies in cases of male infertility.

    abstract::Immunohistochemical and morphological examination of 50 bilateral testicular biopsies of infertile men shows the presence of immunoglobulin in 20% of the cases, suggesting that testicular immune phenomena might be implicated in the pathogenesis of infertility. Several observations make it clear that immune phenomena a...


    pub_type: 杂志文章


    authors: Jadot-Van De Casseye M,De Bled G,Gepts W,Schoysman R

    更新日期:1980-03-01 00:00:00

  • The effects of vasectomy on viscosity, pH and volume of semen in man.

    abstract::The effects of vasectomy on seminal viscosity, volume and pH have been investigated in freshly emitted semen of 21 healthy men before operation and three months later. Viscosity and the pH range were decreased significantly, but the decrease of the seminal volume was not significant. Reasons of changes have been discu...


    pub_type: 杂志文章


    authors: Nikkanen V

    更新日期:1979-03-01 00:00:00

  • The antiapoptotic and antioxidant effects of eugenol against cisplatin-induced testicular damage in the experimental model.

    abstract::Testicular dysfunction or damage is among the critical side effects of chemotherapeutic drugs like cisplatin. This study was mapped out to assess the possible therapeutic effect of eugenol on cisplatin-induced testicular damage. In this experimental study, a single dose of cisplatin (15 mg/kg) was given intraperitonea...


    pub_type: 杂志文章


    authors: Ekinci Akdemir FN,Yildirim S,Kandemir FM,Aksu EH,Guler MC,Kiziltunc Ozmen H,Kucukler S,Eser G

    更新日期:2019-10-01 00:00:00

  • [Light and electron microscope studies of the morphology of A spermatogonia in men with normal spermatogenesis and in patients treated with antiandrogens].

    abstract::Based on cytological criteria, three types of A-Spermatogonia may be distinguished in the germinal epithelium of normal men. Cells belonging to Type I conform to A pale spermatogonia and those classified as Type II conform to A dark-spermatogonia according to Clermont ()963). Type III-spermatogonia do not meet the cri...


    pub_type: 杂志文章


    authors: Schulze W

    更新日期:1978-07-01 00:00:00