Kisspeptin and RF9 prevent paroxetine-induced changes in some parameters of seminal vesicle fluid in the male rats.


:The aim of the study was to examine possible impacts of paroxetine and agomelatine on the levels of some components that constitute the seminal vesicle fluid. As a second purpose, it was also aimed to examine how possible negative effects induced by paroxetine on seminal vesicle fluid components were affected by kisspeptin and RF9 (an RFamide-related peptide antagonist, RFRP). Forty-two male rats, aged 21 days, divided into six groups; control, sham, paroxetine, agomelatine, paroxetine + kisspeptin and paroxetine + RF9. Paroxetine (3.6 mg/kg) and agomelatine (10 mg/kg) were administrated by oral gavage. Kisspeptin (1 nmol) and RF9 (20 nmol) were administered intracerebroventricular (i.c.v). The experiments were ended on post-natal 120 days; fructose, vitamin E, sodium, potassium and magnesium levels were measured in seminal vesicle fluid. Fructose, vitamin E, magnesium and potassium levels were significantly decreased in seminal vesicle fluid from the rats treated with paroxetine but did not show significant differences following agomelatine administration. The co-administration of kisspeptin or RF9 with paroxetine prevented the paroxetine-induced negative effects on seminal vesicle fluid components. These results suggest that reduction in sperm fertilising ability caused by changes in seminal vesicle fluid can be seen in long-term antidepressant use. RF-9 and kisspeptin might have positive effects on long-term antidepressant use-induced infertility.






Gulcu Bulmus F,Canpolat S,Sahin Z,Bulmus O,Serhatlioglu I,Kelestimur H




Has Abstract


2020-05-01 00:00:00












  • Mast cells in testicular biopsies of infertile men with 'mixed atrophy' of seminiferous tubules.

    abstract::Mast cells in the bilateral testicular biopsies of 30 patients with a 'mixed atrophy' of seminiferous tubules were analysed. Seven biopsies from vasectomized patients served as controls. With regard to their characteristic location within testicular tissue, two groups of mast cells could be distinguished, in both cont...


    pub_type: 杂志文章


    authors: Jezek D,Banek L,Hittmair A,Pezerović-Panijan R,Goluza T,Schulze W

    更新日期:1999-07-01 00:00:00

  • Icariin improves SHR erectile function via inhibiting eNOS uncoupling.

    abstract::The aim of the study was to investigate whether or not the effect of icariin on erectile function of SHR is associated with inhibition of eNOS uncoupling. Ten 12-week-old male WKY rats and 10 age-matched male SHR were evenly randomised into SHR control group, SHR+ icariin treatment group, WKY control group and WKY+ ic...


    pub_type: 杂志文章


    authors: Long H,Jiang J,Xia J,Jiang R

    更新日期:2018-11-01 00:00:00

  • The effects of hesperidin on colistin-induced reproductive damage, autophagy, and apoptosis by reducing oxidative stress.

    abstract::This study has been conducted to investigate the effect of hesperidin on colistin-induced reproductive damage in male rats. Twenty-four adult male Sprague Dawley rats were used as animal material. They were divided into four groups: control group, received physiological saline for 7 days by oral gavage; hesperidin gro...


    pub_type: 杂志文章


    authors: Aksu EH,Kandemir FM,Küçükler S

    更新日期:2020-12-01 00:00:00

  • Reliable single sperm cryopreservation in Cell Sleepers for azoospermia management.

    abstract::Conventional sperm freezing methods perform best when freezing sperm samples containing at least hundreds of spermatozoa. In this severe male factor infertility case series, we examined the reproductive outcomes in 12 intracytoplasmic sperm injection cases where spermatozoa used were frozen in Cell Sleepers. Cell Slee...


    pub_type: 杂志文章


    authors: Coetzee K,Ozgur K,Berkkanoglu M,Bulut H,Isikli A

    更新日期:2016-03-01 00:00:00

  • Disorder of hypothalamic-pituitary-gonadal axis induced by abusing of anabolic-androgenic steroids for short time: A case report.

    abstract::The aim of this study was to evaluate the hypothalamic-pituitary-gonadal axis functionality on a bodybuilding competitioner before, during and after the use of anabolic-androgenic steroids. A young healthy man was followed up for 4 months. The subject reported his drug administration protocol through periodic intervie...




    authors: Vilar Neto JO,da Silva CA,Lima AB,Caminha JSR,Pinto DV,Alves FR,Araújo JS,Daher EF

    更新日期:2018-11-01 00:00:00

  • Multicentre study of Y chromosome microdeletions in 1,808 Chinese infertile males using multiplex and real-time polymerase chain reaction.

    abstract::Azoospermia factor (AZF) genes on the long arm of the human Y chromosome are involved in spermatogenesis, and microdeletions in the AZF region have been recognised to be the second major genetic cause of spermatogenetic failure resulting in male infertility. While screening for these microdeletions can avoid unnecessa...


    pub_type: 杂志文章,多中心研究


    authors: Zhu XB,Gong YH,He J,Guo AL,Zhi EL,Yao JE,Zhu BS,Zhang AJ,Li Z

    更新日期:2017-06-01 00:00:00

  • Evaluation of effectiveness of antiandrogen treatments on cavernosal tissues in rats.

    abstract::In this study, we aimed to compare changes in cavernosal tissues in rats with antiandrogen treatment and orchiectomy. A total of 42 Wistar albino rats were divided into four groups. Group I, control group, Group II, LH-RH was given for 1 month, Group III-LH-RH + Bicalutamide was given for 1 month, and Group IV was def...


    pub_type: 杂志文章


    authors: Firat F,Erdemir F,Günaydın B,Parlaktas BS,Markoç F,Yaşar A

    更新日期:2020-06-01 00:00:00

  • Ethanol-extracted Cameroonian propolis: Antiproliferative effects and potential mechanism of action in prostate cancer.

    abstract::The present study was conducted to evaluate in vitro and in vivo antiproliferative potential of the Cameroonian propolis and to elucidate its underlying mechanism. In vitro, ethanol-extracted propolis (EEP) was tested on cell growth, cell proliferation, cell cycle, cell death mechanism and cell migration. The cell cyc...


    pub_type: 杂志文章


    authors: Zingue S,Maxeiner S,Rutz J,Ndinteh DT,Chun FK,Fohouo FT,Njamen D,Blaheta RA

    更新日期:2020-10-01 00:00:00

  • Protective effects of Eugenia jambolana extract versus N-acetyl cysteine against cisplatin-induced damage in rat testis.

    abstract::To assess the protective effects of Eugenia jambolana extract (EJE) or N-acetyl cysteine (NAC) on testis, cisplatin (CIS, 5 mg kg(-1) bw, single dose) was administered either alone or along with EJE (25 mg kg(-1) bw, alternate day) or NAC (150 mg kg(-1) bw, Day 1 and 4) for 7 days. Significant alterations in serum LH,...


    pub_type: 杂志文章


    authors: Anand H,Misro MM,Sharma SB,Prakash S

    更新日期:2015-03-01 00:00:00

  • Dimethylformamide is not better than glycerol for cryopreservation of boar semen.

    abstract::To improve the boar sperm cryopreservation process, the influence of the sugar (lactose, trehalose) source and the cryoprotectant [glycerol, dimethylformamide (DMF)] on the success of freezing was investigated. Sperm samples were frozen in one of six extenders: lactose plus 3% glycerol (LG); lactose plus 1.5% glycerol...


    pub_type: 杂志文章


    authors: Malo C,Gil L,Cano R,Martínez F,García A,Jerez RA

    更新日期:2012-05-01 00:00:00

  • Effects of H(2)O(2) exposure on human sperm motility parameters, reactive oxygen species levels and nitric oxide levels.

    abstract::Research has revealed that reactive oxygen species (ROS) negatively affect sperm function, both in vivo and in vitro. Sperm preparation techniques for assisted reproductive technologies (ART) are potential causes for additional ROS production. This study aimed to correlate the concentration of exogenous H(2)O(2) with ...


    pub_type: 杂志文章


    authors: du Plessis SS,McAllister DA,Luu A,Savia J,Agarwal A,Lampiao F

    更新日期:2010-06-01 00:00:00

  • Azoospermia and Sertoli-cell-only syndrome: hypoxia in the sperm production site due to impairment in venous drainage of male reproductive system.

    abstract::Sertoli-cell-only (SCO) syndrome, or germ cell aplasia, is diagnosed on testicular biopsy when germ cells are seen to be absent without histological impairment of Sertoli or Leydig cells. It is considered a situation of irreversible infertility. Recent studies have shown that varicocele, a bilateral disease, causes hy...


    pub_type: 杂志文章


    authors: Gat Y,Gornish M,Perlow A,Chakraborty J,Levinger U,Ben-Shlomo I,Pasqualotto F

    更新日期:2010-10-01 00:00:00

  • Azoospermia in a renal transplant recipient during sirolimus (rapamycin) treatment.

    abstract::Sirolimus is used as a powerful immunosuppressant drug in patients after organ transplantation. It was shown to block spermatogenesis by interrupting the stem cell factor/c-kit system. Oligozoospermia was shown in single patients. In addition, a decrease of testosterone and an increase of gonadotropin levels were obse...


    pub_type: 杂志文章


    authors: Skrzypek J,Krause W

    更新日期:2007-10-01 00:00:00

  • Preliminary observations on steroid metabolism in isolated epithelum of guinea pig seminal vesicle.

    abstract::The metabolism of nine radioactively labeled steroids in the epithelium of the seminal vesicle of the mature guinea pig has been studied. The rapid assimilation and metabolism of these steroids demostrate the very active biochemical nature of this tissue. Based on the use of several thin-layer chromatography systems a...


    pub_type: 杂志文章


    authors: Steer RC,Veneziale CM

    更新日期:1977-04-01 00:00:00

  • [Attempts at localisation and evaluation of the RNA amounts in the tail and the cytoplasmic droplet of bull spermatozoa].

    abstract::The RNA has been located and proportioned by a spectrophotometric method which absorbs the ultra-violet light. The technique used allows us to execute punctual dosage into the spermatozoon's tail. Each of these punctual dosages makes us realise the RNA localisation; and the sum of these dosages makes us realise the to...


    pub_type: 杂志文章


    authors: Henriet L

    更新日期:1975-01-01 00:00:00

  • Significance of CFTR gene mutations in patients with congenital aplasia of vas deferens with special regard to renal aplasia.

    abstract::Between 1994 and 2010, a total of 123 patients with obstructive azoospermia due to aplasia of vas deferens (CAVD) were surgically treated. In 110 patients, the condition was bilateral (CBAVD), 13 men had unilateral aplasia (CUAVD), and 10 patients additionally had aplasia of one kidney. All patients underwent CFTR gen...


    pub_type: 杂志文章


    authors: Schwarzer JU,Schwarz M

    更新日期:2012-10-01 00:00:00

  • Maternal and infant characteristics influencing the anogenital distance and penile length in newborns.

    abstract::Recent studies have suggested that maternal characteristics can affect reproductive health of offspring, possibly through pre-natal hormonal influence. Anogenital distance (AGD) is an anthropometric measure which is a sensitive reproductive endpoint of masculinisation. It provides a read-out of pre-natal androgen expo...


    pub_type: 杂志文章


    authors: Singal AK,Jain VG

    更新日期:2016-08-01 00:00:00

  • Dopamine D2 receptors in the basolateral amygdala modulate erectile function in a rat model of nonorganic erectile dysfunction.

    abstract::Nonorganic erectile dysfunction is a problem with unknown central mechanisms. Changes in brain activity in the amygdala have been observed in human patients. This study aimed to investigate the dopamine system in the basolateral amygdala of male rats with nonorganic erectile dysfunction. We applied chronic mild stress...


    pub_type: 杂志文章


    authors: Chen G,Chen J,Yang B,Yu W,Chen Y,Dai Y

    更新日期:2019-02-01 00:00:00

  • The effects of different dietary protein sources on live weight, sperm quality and the histology of the testes and accessory glands in male rats.

    abstract::This study was aimed at determining the effects of corn and wheat gluten, used as dietary protein sources, on live weight gain, sperm quality and the histology of the testes and accessory glands in male rats. For this purpose, 20-day-old 24 male Wistar albino rats were randomly assigned to three groups. Group 1 (Contr...


    pub_type: 杂志文章


    authors: Gumus R,Uslu S,Uslu BA

    更新日期:2020-07-01 00:00:00

  • The ameliorative effects of methylene blue on testicular damage induced by cisplatin in rats.

    abstract::Cisplatin, a common chemotherapeutic drug, can induce testicular toxicity. Methylene blue, a potent antioxidant, can inhibit the generation of free radicals. This research aimed to study the protective effect of methylene blue against the cisplatin-induced toxicity of the reproductive system in rats. 35 male Wistar ra...


    pub_type: 杂志文章


    authors: Gholami Jourabi F,Yari S,Amiri P,Heidarianpour A,Hashemi H

    更新日期:2021-02-01 00:00:00

  • Comparative cytomorphologic aspects of the male germ cells, especially of the "Gonia".

    abstract::During early development of the human testis the male germ cell first appears as primordial germ cell or gonocyte and enters the prospermatogonial stage after the twelfth week of gestation. Prospermatogonia lack glycogen particles and are connected by intercellular bridges. During the same period in the ovary the fema...


    pub_type: 杂志文章


    authors: Wartenberg H

    更新日期:1976-01-01 00:00:00

  • The physiology of male reproduction: Impact of drugs and their abuse on male fertility.

    abstract::Male factor accounts for about 30-50% of infertility. A common cause of male infertility is drug abuse; either illicit or prolonged use of prescribed drugs. This study provides a review of the physiology of the hypothalamic-pituitary-gonadal axis and recent literature on drugs that have been linked to male infertility...


    pub_type: 杂志文章,评审


    authors: Ajayi AF,Akhigbe RE

    更新日期:2020-10-01 00:00:00

  • Enzymatic properties of adult human Sertoli cells in vitro.

    abstract::The adult human Sertoli cells produced lactate, estradiol-17beta, transferrin and inhibin; germ cells modulate synthesis of these compounds. In order to study the functional features of human Sertoli cells in vitro, the aim of this study was to measure the lactic dehydrogenase (LDH), gamma-glutamyl transpeptidase (GGT...


    pub_type: 杂志文章


    authors: Carreau S,Drosdowsky MA,Foucault P

    更新日期:1996-03-01 00:00:00

  • Update on the impact of Chlamydia trachomatis infection on male fertility.

    abstract::With approximately 90 million cases annually, infection with Chlamydia trachomatis is the most prevalent sexually transmitted bacterial disease in the world. Considering that these infections are often asymptomatic and cause major complications like acute pelvic inflammatory disease, ectopic pregnancy, infertility or ...


    pub_type: 杂志文章,评审


    authors: Gonzales GF,Muñoz G,Sánchez R,Henkel R,Gallegos-Avila G,Díaz-Gutierrez O,Vigil P,Vásquez F,Kortebani G,Mazzolli A,Bustos-Obregón E

    更新日期:2004-02-01 00:00:00

  • Role of the hypothalamic opioidergic system in the control of gonadotropin secretion in elderly men.

    abstract::The role of opioidergic system in controlling gonadotropin secretion in elderly men still remains uncertain. In the present study, we attempted to examine the opioidergic inhibitory tone imposed on GnRH release mechanism in elderly men by monitoring the plasma gonadotropin response to the opiate receptor antagonist na...


    pub_type: 杂志文章


    authors: Mikuma N,Kumamoto Y,Maruta H,Nitta T

    更新日期:1994-01-01 00:00:00

  • The presence of progressive motility sustaining factor (PMSF) in human epididymis.

    abstract::Progressive Motility Sustaining Factor (PMSF) was isolated from human epididymides. PMSF could significantly improve progressive motility of oligozoospermic as well as asthenozoospermic semen. PMSF was found to increase cyclic AMP accumulation by the human spermatozoa indicating its possible mode of action. ...


    pub_type: 杂志文章


    authors: Sheth AR,Gunjikar AN,Shah GV

    更新日期:1981-03-01 00:00:00

  • Influence of bacteria and leukocytes on the outcome of in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI).

    abstract::The influence of bacteria and/or leukocytes on the outcome of IVF or ICSI is influenced by three factors which have little in common with in vivo conditions: 1) The process of ejaculate preparation (swim-up, Percoll) with antibiotic buffered media; 2) The small amount of inseminated spermatozoa (100,000 per culture); ...


    pub_type: 杂志文章,评审


    authors: Michelmann HW

    更新日期:1998-01-01 00:00:00

  • Treatment with levofloxacin does not resolve asymptomatic leucocytospermia--a randomized controlled study.

    abstract::The manual of the World Health Organization defines leucocytospermia as the presence of >1 x 10(6) white blood cells per ml semen. Most authors consider leucocytospermia to be a consequence of inflammation due to bacterial infection. However, the efficacy of antibiotic therapy was not unequivocally demonstrated until ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Krisp A,Hörster S,Skrzypek J,Krause W

    更新日期:2003-08-01 00:00:00

  • Epididymal sperm reserve in Buffalo-bulls (Bubalus bubalis).

    abstract::Epididymal sperm reserve was determined in 6 sexually mature fertile buffalo-bulls having normal process of spermatogenesis. The relative distribution of spermatozoa in the caput, corpus and cauda epididymidis averaged 5.42, 0.75 and 11.45 billion respectively. Total epididymal sperm reserve per bull averaged 36.2 bil...


    pub_type: 杂志文章


    authors: Sharma AK,Gupta RC

    更新日期:1978-11-01 00:00:00

  • The evaluation of free-L-carnitine, zinc and fructose in the seminal plasma of patients with varicocele and normozoospermia.

    abstract::The function of the epididymis and of the sex accessory glands have been investigated in a selected group of varicocele patients with normal sperm count. In the seminal plasma of these patients free-L-carnitine, fructose and zinc levels were determined as functional markers respectively of epididymis, seminal vesicles...


    pub_type: 杂志文章


    authors: Andó S,Carpino A,Buffone M,Maggiolini M,Sisci D

    更新日期:1989-03-01 00:00:00