Chronic lead treatment affects dopaminergic control of prolactin secretion in rat pituitary.

abstract：:The involvement of neurotrophins after radiation injury during brain development were studied in pregnant mice (C 57/B1) exposed on gestation day 15 to X-ray doses of 0.02-2 Gy. Nerve growth factor protein (NGF) and different cholinergic markers were investigated on postnatal day 1 (P1) and day 21 (P21); in situ hybri...

journal_title：Toxicology letters

authors： Dimberg Y,Vazquez M,Söderström S,Ebendal T

更新日期：1997-01-15 00:00:00

abstract：:There are reports of fluorochloridone (FLC)-induced male reproductive toxicity, but the underlying toxicological mechanisms remain unknown. In this study, we looked at how FLC exposure affected the integrity of the blood-testis barrier (BTB) and the Sertoli cell barrier and studied the molecular mechanisms. Male rats ...

journal_title：Toxicology letters

authors： Liu L,Zhang Y,Chang X,Li R,Wu C,Tang L,Zhou Z

更新日期：2018-10-01 00:00:00

abstract：:This study was designed to compare the pulmonary cellular proliferative effects of inhaled, size-separated preparations of chrysotile asbestos fibres with similar aerosol fibre concentrations of para-aramid fibrils. Following fibre preparation, rats were exposed for 2 weeks to aerosols of p-aramid fibrils or chrysotil...

journal_title：Toxicology letters

authors： Warheit DB,Hartsky MA,Frame SR

更新日期：1996-11-01 00:00:00

abstract：:Plant protection products have to be evaluated and authorized in the EC-Member States since 1993 in accordance with Directive 91/414/EEC. The programme for evaluating existing active substances (which were on the market before July 1993) involves several steps and stages, stretching over a period of up to formerly 10,...

journal_title：Toxicology letters

authors： Flynn DJ,Lundehn JR

更新日期：2004-04-01 00:00:00

abstract：:Shikonin, a natural red colorant, is widely used for food garnishment and cosmetic ingredient in the world. Shikonin also possesses a variety of pharmacological actions, including anti-inflammation and anti-cancer activities. However, little is known about its effects on the UDP-glucuronosyltransferases (UGT) activity...

journal_title：Toxicology letters

authors： Cheng Y,Tang S,Chen A,Zhang Y,Liu M,Wang X

更新日期：2019-09-15 00:00:00

abstract：:This study was initiated to identify a marker of choice to monitor occupational exposure to toluene through quantitative evaluation of changes in correlation coefficients (CCs), taking advantage of a large database. Six known or proposed exposure markers in end-of-shift blood (B) and urine (U) were studied, i.e., tolu...

journal_title：Toxicology letters

authors： Ikeda M,Ukai H,Kawai T,Inoue O,Maejima Y,Fukui Y,Ohashi F,Okamoto S,Takada S,Sakurai H

更新日期：2008-07-10 00:00:00

abstract：:The hedgehog (HH) signaling pathway plays an important role in lung development, but its significance in silicosis is unclear. We showed that in human coal pneumoconiosis autopsy specimens, Sonic Hedgehog (SHH) and the Glioma-associated oncogene homolog transcription factors family (GLI) 1 proteins were up-regulated, ...

journal_title：Toxicology letters

authors： Zhang B,Xu H,Zhang Y,Yi X,Zhang G,Zhang X,Xu D,Gao X,Li S,Zhu Y,Zhang H,Wei Z,Li S,Zhang L,Wang R,Yang F

更新日期：2019-10-01 00:00:00

abstract：:A low-Mr copper (Cu) and zinc (Zn)-binding protein was present in the liver of a control water lizard Triturus pyrrhogaster. Cadmium (Cd) accumulated in the liver of the animals after intramuscular injections of Cd salt and was bound to Cu- and Zn-binding protein of a single isoform that had properties characteristic ...

journal_title：Toxicology letters

authors： Suzuki KT,Akitomi H,Kawamura R

更新日期：1984-05-01 00:00:00

abstract：:Although CSL box jellyfish antivenom (AV) remains the primary treatment for Chironex fleckeri envenoming, there has been considerable debate regarding its clinical effectiveness. Animal studies have shown that AV is largely ineffective in preventing C. fleckeri-induced cardiovascular collapse. This study examined the ...

journal_title：Toxicology letters

authors： Winter KL,Isbister GK,Jacoby T,Seymour JE,Hodgson WC

更新日期：2009-06-01 00:00:00

abstract：:Toxicological data used for risk assessments must undergo an evaluation of reliability. Nevertheless, a reliability evaluation scheme for such data has yet to be established in China. A method termed TRAM (Toxicological data Reliability Assessment Method) was developed to evaluate toxicological data reliability. A que...

journal_title：Toxicology letters

authors： Bian Q,Ping Y,Jun W,Lyu Z,Song Y,Zhang L,Liu Z

更新日期：2019-09-01 00:00:00

abstract：:The elution profile of urine from rats given 63Ni i.p. using a Sephadex G-25 column was studied to investigate the chemical form and pattern of nickel (Ni) excretion. Ni was excreted probably as a mixture of complexes with chemical constituents of urine (molecular weight 200-250) within 24 h after 63Ni injection. 63Ni...

journal_title：Toxicology letters

authors： Verma HS,Behari JR,Tandon SK

更新日期：1980-03-01 00:00:00

abstract：:Inflammation is one of the factors that may increase the sensitivity of hepatic cells to acetaminophen (APAP) induced toxicity. To investigate the mechanisms, we exposed 3-dimensional (3D) Human Liver Microtissues, a co-culture of primary human hepatocytes (PHH) and Kupffer cells (KCs), to 0, 0.5 (low), 5 (median) and...

journal_title：Toxicology letters

authors： Jiang J,Messner S,Kelm JM,van Herwijnen M,Jennen DGJ,Kleinjans JC,de Kok TM

更新日期：2019-09-15 00:00:00

abstract：:This study attempted the liposomalization of coproporphyrin I (CPI) with hydrophobic properties. Liposomalization of CPI was not successful at any pH when using lactate buffer. In contrast, when using 9% sucrose/10mM phosphate buffer (pH 7.8), CPI liposomes (Lipo-CPI) and polyethyleneglycol (PEG) modified liposomes (P...

journal_title：Toxicology letters

authors： Sadzuka Y,Iwasaki F,Sugiyama I,Horiuchi K,Hirano T,Ozawa H,Kanayama N,Oku N

更新日期：2008-11-10 00:00:00

abstract：:Genomic DNA is under continuous assault by various chemical species produced by normal cellular metabolism. In addition, exposure to exogenous agents adds further insult. Modification of DNA by chemical carcinogens has long been recognized as an early event in carcinogenesis and many DNA adducts have been characterize...

journal_title：Toxicology letters

authors： Shuker DE

更新日期：2002-08-05 00:00:00

abstract：:The blood-brain barrier (BBB) is critical to maintain cerebral homeostasis. In this study, we examined the effects of exposure to electromagnetic pulse (EMP) on the functional integrity of BBB and, on the localization and expression of tight junction (TJ) proteins (occludin and ZO-1) in rats. Animals were sham or whol...

journal_title：Toxicology letters

authors： Ding GR,Qiu LB,Wang XW,Li KC,Zhou YC,Zhou Y,Zhang J,Zhou JX,Li YR,Guo GZ

更新日期：2010-07-15 00:00:00

abstract：:Aflatoxin is a fungal secondary metabolite with high toxicity that is capable of contaminating various types of food crops. It has been identified as a Group 1 human carcinogen by the International Agency for Research on Cancer. Chronic aflatoxin exposure has caused worldwide concern as a matter of public food safety....

journal_title：Toxicology letters

authors： Wang X,You SH,Lien KW,Ling MP

更新日期：2019-10-10 00:00:00

abstract：:An overview of values for the threshold of toxicological concern (TTC) is presented. This comprises the more established TTC values, including those that have been endorsed by regulatory bodies, and those that have more recently been proposed and may still need further development. The overview is structured by use/ex...

journal_title：Toxicology letters

authors： Hennes EC

更新日期：2012-06-20 00:00:00

abstract：:There is experimental and epidemiological evidence demonstrating that polycyclic aromatic hydrocarbons (PAHs) are involved in the pathogenesis of cardiovascular diseases. However, heterocyclic amines (HAs), a class of carcinogenic compounds present in food, which share many biochemical features with PAHs, have not rec...

journal_title：Toxicology letters

authors： Lopez-Mendez C,Bermudez-Fajardo A,Ioannides C,Oviedo-Orta E

更新日期：2009-03-10 00:00:00

abstract：:The polychlorinated biphenyls (PCBs) have been demonstrated to be inducers of hepatic microsomal enzymes and some of their effects such as hormonal imbalance, and alteration of lipid and porphyrin metabolism could be ascribed to this mechanism. For this reason, the urinary excretion of D-glucaric acid (DGA), an indire...

journal_title：Toxicology letters

authors： Apostoli P,Mangili A,Carasi S,Manno M

更新日期：2003-09-15 00:00:00

abstract：:Primary renal neoplasms in the rats are uncommon. Nephroblastoma is the only renal embryonal tumor of the rat; all other tumors are reported in older rats. The occurrence of spontaneous nephroblastoma in rats has been reported. However, metastasis from the nephroblastoma in rat is extremely rare. Data from 2669 Spragu...

journal_title：Toxicology letters

authors： Chandra M,Carlton WW

更新日期：1992-09-01 00:00:00

abstract：:Exposure of C57Bl mice to 10 ppm benzene (the current occupational exposure limit) for 6 h/day, 5 days/week causes a progressive depression in the in vitro colony forming ability of one of the erythroid progenitor cells, the colony-forming unit-erythroid (CFU-E). Colony growth of cells from exposed mice was only 5% of...

journal_title：Toxicology letters

authors： Baarson KA,Snyder CA,Albert RE

更新日期：1984-03-01 00:00:00

abstract：:Heart rate (HR) and body core temperature (Tco) were monitored in unanesthetized, unrestrained adult Sprague-Dawley rats following intraperitoneal administration of 0, 10, 30, or 60 mg/kg of the pesticide chlordimeform (CDM). Significant non-dose-related decreases were observed in both HR and Tco in all treated groups...

journal_title：Toxicology letters

authors： Watkinson WP,Gordon CJ

更新日期：1987-02-01 00:00:00

abstract：:Recently, spermatogenic cell apoptosis was shown to play a key role in the induction of testicular atrophy by dibutyl phthalate (DBP), thus causing reproductive toxicology. However, the molecular events induced by DBP in apoptotic germ cells remain unclear. In the present study, the mouse spermatocyte-derived GC-2 cel...

journal_title：Toxicology letters

authors： Zhang G,Liu K,Ling X,Wang Z,Zou P,Wang X,Gao J,Yin L,Zhang X,Liu J,Ao L,Cao J

更新日期：2016-03-14 00:00:00

abstract：:Because coarse mode particles are rarely studied in their existing size ranges (greatest mass about 5-7 microns, aerodynamic diameter), we investigated the effects of four such particles, quartz, ferric oxide, calcium carbonate, and sodium feldspar, on host defenses against bacterial pulmonary infection. Mice which re...

journal_title：Toxicology letters

authors： Aranyi C,Graf JL,O'Shea WJ,Graham JA,Miller FJ

更新日期：1983-10-01 00:00:00

abstract：:In order to gain basic understanding in the ecotoxicity of endocrine disrupting chemicals or EDCs (including natural chemicals and some pharmaceuticals), many international research groups are currently testing these chemicals using aquatic invertebrates. This paper discusses relevant examples to address key questions...

journal_title：Toxicology letters

authors： Hutchinson TH

更新日期：2002-05-10 00:00:00

abstract：:The fast growing applications of ZnO nanoparticles (NPs) in food sector and other fields enhance the exposure possibility of human beings to ZnO NPs including via oral administration route. Although the oral toxicity of ZnO NPs has been studied, most of the research was performed on the normal animal models. Therefore...

journal_title：Toxicology letters

authors： Du LJ,Xiang K,Liu JH,Song ZM,Liu Y,Cao A,Wang H

更新日期：2018-10-01 00:00:00

abstract：:The modern environmental awareness leads to the realisation that the human metabolism is stressed by a huge number of chemical substances. Generally, these background exposures, consisting predominantly from natural and partly from industrial as well as life style sources, are tolerated without any adverse effects. Pe...

journal_title：Toxicology letters

authors： Lewalter J,Leng G

更新日期：1999-06-30 00:00:00

abstract：:PFAS are man-made compounds that are highly spread in the environment. Human dietary exposure to such contaminants is of high concern as they may accumulate in the food chain. Different studies already demonstrated the importance of the fish consumption in the dietary exposure of these molecules and the potential incr...

journal_title：Toxicology letters

authors： Denys S,Fraize-Frontier S,Moussa O,Le Bizec B,Veyrand B,Volatier JL

更新日期：2014-12-01 00:00:00

abstract：:The proceedings in this volume suggest several important future research needs. Research is needed to validate modeling in toxicology in order to support the use of the general approach of modeling, either for structure-activity relationships (SAR) or physiologically based pharmacokinetics (PBPK), by regulators. Resea...

journal_title：Toxicology letters

authors： Menzel DB

更新日期：1995-09-01 00:00:00

abstract：:The effect of paraquat on lung subcellular calcium transport was studied in male Sprague-Dawley rats. With a high dose of 30 mg/kg given i.p., a significant decrease in the lung mitochondrial and microsomal calcium uptake at 24, 48, and 72 h after paraquat was observed. Trend of recovery was evident at 96 h in the sur...

journal_title：Toxicology letters

authors： Agarwal AK,Coleman JW

更新日期：1988-09-01 00:00:00