Effects of propranolol on regional myocardial blood flow and function during severe coronary stenosis in dogs.

abstract：:Prazosin is believed to have an antihypertensive action due to a selective blockade of alpha-adrenoceptors on vascular smooth muscle. Using an in vitro autoradiographic technique specific binding of [3H]prazosin to the abdominal aorta and renal artery in the rat has been shown. The binding of [3H]prazosin to arterial ...

journal_title：European journal of pharmacology

authors： Dashwood M,Bagnall J

更新日期：1982-02-19 00:00:00

abstract：:Exosomes are membrane-derived vesicles and play a critical role in cell signaling by transferring RNAs and proteins to target cells through fusion with the cell membrane. Long non-coding RNA-small nucleolar RNA host gene 9 (lncRNA-SNHG9) was proven to be an important element in lncRNA-mRNA interaction networks during ...

journal_title：European journal of pharmacology

authors： Song Y,Li H,Ren X,Li H,Feng C

更新日期：2020-04-05 00:00:00

abstract：:Migraine is a common painful neurovascular disorder usually associated with several symptoms, such as photophobia, phonophobia, nausea, vomiting and inflammation, and involves immune cells. Mast cells (MCs) are immune cells derived from hematopoietic pluripotent stem cells which migrate and mature close to epithelial,...

journal_title：European journal of pharmacology

authors： Conti P,D'Ovidio C,Conti C,Gallenga CE,Lauritano D,Caraffa A,Kritas SK,Ronconi G

更新日期：2019-02-05 00:00:00

abstract：:The infectious coronavirus disease (COVID-19) pandemic, caused by the coronavirus SARS-CoV-2, appeared in December 2019 in Wuhan, China, and has spread worldwide. As of today, more than 46 million people have been infected and over 1.2 million fatalities. With the purpose of contributing to the development of effectiv...

journal_title：European journal of pharmacology

authors： Cavasotto CN,Lamas MS,Maggini J

更新日期：2021-01-05 00:00:00

abstract：:The characteristics of the prefrontal cortex regulation of dopamine release in the rat dorsolateral striatum were investigated in focusing on the corticostriatal pathway, using dual-probe microdialysis in combination with simple behavioral procedures. Intracortical perfusion of the GABA(A) receptor antagonist bicucull...

journal_title：European journal of pharmacology

authors： Matsumoto M,Kanno M,Togashi H,Ueno K,Otani H,Mano Y,Yoshioka M

更新日期：2003-12-15 00:00:00

abstract：:Airway remodeling in asthma is difficult to treat because of its complex pathophysiology that involves proinflammatory cytokines, as well as the arachidonic acid cytochrome P-450 (CYP) pathway; however, it has received little attention. In this study, we assessed the efficacy of a soluble epoxide hydrolase (sEH) on ai...

journal_title：European journal of pharmacology

authors： Jiang JX,Guan Y,Shen HJ,Jia YL,Shen J,Zhang LH,Liu Q,Zhu YL,Xie QM

更新日期：2020-02-05 00:00:00

abstract：:Given the differences in the dopamine neurotransmission between the shell and the core of the nucleus accumbens, as well as the differential involvement of these two domains in oral behaviour of rats, it was decided to determine whether or not dopamine D1 and/or dopamine D2 receptors differentially direct oral behavio...

journal_title：European journal of pharmacology

authors： Cools AR,Miwa Y,Koshikawa N

更新日期：1995-11-03 00:00:00

abstract：:In the brain, various neurotransmitters such as noradrenaline and GABA regulate peripheral sympathetic functions. Previously, it has been reported that both β-adrenoceptor activation and GABAB receptor activation in the brain are involved in the elevation of plasma noradrenaline levels. However, it is unknown whether ...

journal_title：European journal of pharmacology

authors： Yamaguchi N,Mimura K,Okada S

更新日期：2019-04-05 00:00:00

abstract：:Exposure to cold (4 degrees C) of catheterized rats acclimated to 20 degrees C resulted in a progressive increase in plasma noradrenaline (NA) concentrations which reached values consistently more than twice the basal ones (20 degrees C) by about 30 min. No further increase in plasma NA levels were detected when the c...

journal_title：European journal of pharmacology

authors： Picotti GB,Carruba MO,Ravazzani C,Cesura AM,Galva MD,Da Prada M

更新日期：1981-01-29 00:00:00

abstract：:The acute administration of MDMA has been shown to promote glycogenolysis and increase the extracellular concentration of glucose in the striatum. In the present study the role of serotonergic and/or noradrenergic mechanisms in the MDMA-induced increase in extracellular glucose and glycogenolysis was assessed. The rel...

journal_title：European journal of pharmacology

authors： Pachmerhiwala R,Bhide N,Straiko M,Gudelsky GA

更新日期：2010-10-10 00:00:00

abstract：:A few decades ago, cardiac muscle was discovered to possess signalling pathways that, when activated, protect the myocardium against the damage induced by ischaemia-reperfusion. The ability of cardiac muscle to protect itself against injury has been termed 'cardioprotection'. Many compounds and procedures can trigger ...

journal_title：European journal of pharmacology

authors： Jovanović A

更新日期：2018-08-15 00:00:00

abstract：:The weak aminotetralin stimulants, (+)-AJ 76, cis-(+)-5-methoxy-1-methyl-2-(n-propylamino)tetralin and (+)-UH 232, cis-(+)-5-methoxy-1-methyl-2-(di-n-propylamino)tetralin, were tested for their effects on firing rates of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNPC). (+)-AJ 76 and (+)-UH 232 a...

journal_title：European journal of pharmacology

authors： Piercey MF,Lum JT

更新日期：1990-07-03 00:00:00

abstract：:The failure of alpha 1-adrenoceptor antagonists, prazosin and indoramin, to cause a reflex tachycardia was investigated in the anaesthetised cat. Recordings were made of preganglionic sympathetic nerve activity from the third or fourth white ramus communicans, femoral arterial conductance, heart rate and blood pressur...

journal_title：European journal of pharmacology

authors： Ramage AG

更新日期：1984-11-27 00:00:00

abstract：:The effect of omega-conotoxin on opiate analgesia and withdrawal syndrome was investigated in rats. omega-Conotoxin given i.c.v. and i.p. caused weak analgesia in the tail-flick test. When the toxin (20 ng/rat) was given i.c.v. immediately before morphine (1.5 micrograms/rat i.c.v.) the resultant analgesic effect was ...

journal_title：European journal of pharmacology

authors： Basilico L,Parolaro D,Rubino T,Gori E,Giagnoni G

更新日期：1992-07-21 00:00:00

abstract：:The effects of indapamide on contractile responses in various isolated artery rings and on spontaneous mechanical activity in portal vein segments were investigated. Arteries used were: rabbit aorta, mesenteric (fifth branch), femoral and basilar, and sheep coronary arteries. 45Ca2+ uptake was also analysed in rabbit ...

journal_title：European journal of pharmacology

authors： Del Rio M,Chulia T,Gonzalez P,Tejerina T

更新日期：1993-11-30 00:00:00

abstract：:Oral methylnalorphine ( methylnalorphinium ) caused a dose-dependent selective inhibition of inflammatory hyperalgesia (measured in the rat by a modified version of the Randall- Selitto test) without affecting the oedema. When subcutaneously injected, repeated doses of morphine for 5 days caused progressive analgesic ...

journal_title：European journal of pharmacology

authors： Ferreira SH,Lorenzetti BB,Rae GA

更新日期：1984-03-16 00:00:00

abstract：:The effect and role of nitric oxide (NO) in the regulation of ion transport in the mouse cecum were investigated. L-arginine, used to increase NO production, increased short-circuit current (Isc), a measure of ion transport, in a concentration-dependent manner with a maximal increase of 193.8+/-65.5 microA/cm2. This i...

journal_title：European journal of pharmacology

authors： Homaidan FR,Martello LA,Melson SJ,Burakoff R

更新日期：1998-05-29 00:00:00

abstract：:Sesamin is a major component in lignans of sesame seed oil, known to possess potent anti-oxidative capacity. In this study, the variation of heme oxygenase (HO)-1, a kind of anti-oxidative enzyme, by sesamin in murine macrophage cell line RAW 264.7 cells was investigated. Lipopolysaccharide (LPS; 10μg/ml) exposure ten...

journal_title：European journal of pharmacology

authors： Fukunaga M,Ohnishi M,Shiratsuchi A,Kawakami T,Takahashi M,Motomura M,Egusa K,Urasaki T,Inoue A

更新日期：2014-10-15 00:00:00

abstract：:Inflammatory processes are critical promoting factors of chronic pain states, mostly by inducing peripheral and central sensitization of the nociceptive system. These processes are associated with a massive increase in glutamatergic transmission, sometimes facilitated by spinal disinhibition. In this study, we used et...

journal_title：European journal of pharmacology

authors： Gazzo G,Girard P,Kamoun N,Verleye M,Poisbeau P

更新日期：2019-01-15 00:00:00

abstract：:Activation of imidazoline receptors in the central nervous system has protective effect on several types of arrhythmias. We demonstrated that centrally administered rilmenidine, a selective imidazoline receptor agonist, prevented adrenaline-induced arrhythmias during halothane anaesthesia. However, detailed myocardial...

journal_title：European journal of pharmacology

authors： Yamanaka H,Hayashi Y,Iwasaki M,Kamibayashi T,Yamatodani A,Mashimo T

更新日期：2010-11-25 00:00:00

abstract：:The intrathecal injection of a variety of selective kappa-opioid receptor ligands did not result in significant inhibition of thermal nociceptive tail flick responses in rats. In contrast, these compounds dose dependently inhibited pressure nociceptive responses. Cross-tolerance studies revealed that the kappa-opioid ...

journal_title：European journal of pharmacology

authors： Schmauss C

更新日期：1987-06-04 00:00:00

abstract：:Choline displaced [3H]QNB binding from rat brain muscarinic receptors competitively, (Ki = 460 microM) but it was only 1/1000th as potent as ACh. Deanol was an extremely weak displacer of [3H]QNB binding while hemicholinium-3 was 50 times more potent than choline. Although brain levels of choline are well below its Ki...

journal_title：European journal of pharmacology

authors： Speth RC,Yamamura HI

更新日期：1979-09-15 00:00:00

abstract：:This study investigated the antinociceptive action of p-chloro-selenosteroid (PCS), administered by intragastric route (i.g.) to mice against acute models. The contribution of adenosinergic, dopaminergic, serotonergic, nitric oxide and opioid systems was investigated. It was evaluated if the administration of PCS trig...

journal_title：European journal of pharmacology

authors： Marcondes Sari MH,Guerra Souza AC,Gonçalves Rosa S,Souza D,Dorneles Rodrigues OE,Wayne Nogueira C

更新日期：2014-02-15 00:00:00

abstract：:Kakkon-to is composed of seven medicinal herbs and exhibited novel antipyretic activity by suppressing interleukin-1alpha production responsive to interferon in a murine intranasal influenza virus infection model. Using this model, antipyretic compounds with such novel biological activities were characterized from the...

journal_title：European journal of pharmacology

authors： Kurokawa M,Kumeda CA,Yamamura J,Kamiyama T,Shiraki K

更新日期：1998-05-01 00:00:00

abstract：:Somatostatin and gamma-aminobutyric acid (GABA) concentrations were evaluated in the brain of kindled rats treated chronically with carbamazepine and valproic acid. Kindled seizures were almost completely blocked by treatment with carbamazepine, whereas the effect of valproic acid was partial, suppressing only general...

journal_title：European journal of pharmacology

authors： Higuchi T,Yamazaki O,Takazawa A,Kato N,Watanabe N,Minatogawa Y,Yamazaki J,Ohshima H,Nagaki S,Igarashi Y

更新日期：1986-06-17 00:00:00

abstract：:Despite ample in vitro evidence that myofilament Ca(2+)-responsiveness of stunned myocardium is decreased, in vivo data are inconclusive. Conversely, while Ca(2+)-sensitizing agents increase myofilament Ca(2+)-responsiveness in vitro, it has been questioned whether this also occurs in vivo. We therefore tested in open...

journal_title：European journal of pharmacology

authors： de Zeeuw S,Trines SA,Krams R,Duncker DJ,Verdouw PD

更新日期：2000-09-01 00:00:00

abstract：:Baicalein, a naturally occurring flavone, has been proved as a promising chemopreventive compound for many chronic human diseases. The aim of this work was to investigate whether treatment with baicalein prevented nonalcoholic steatohepatitis (NASH) induced by methionine-choline-deficient (MCD) diet. Rats were divided...

journal_title：European journal of pharmacology

authors： Xin HG,Zhang BB,Wu ZQ,Hang XF,Xu WS,Ni W,Zhang RQ,Miao XH

更新日期：2014-09-05 00:00:00

abstract：:Infusion of renal side population (SP) cells, enriched with adult stem-like cells, can ameliorate acute renal failure. We investigated the effects of an angiotensin II type 1 (AT(1)) receptor antagonist, valsartan on SP cell changes in renal injury by ureteral obstruction. Renal SP fraction was reduced by 38%, and the...

journal_title：European journal of pharmacology

authors： Marumo T,Hishikawa K,Matsuzaki Y,Imai N,Takase O,Shimosawa T,Okano H,Fujita T

更新日期：2007-11-14 00:00:00

abstract：:The binding of tritium-labelled BIBP3226, N2-(diphenylacetyl)-N-[(4-hydroxy-phenyl)methyl]-D-arginine amide, to human neuroblastoma SK-N-MC cells was investigated. [3H]BIBP3226 reversibly binds to neuropeptide Y receptors of the Y1 subtype expressed in SK-N-MC cells with a KD of 2.1 +/- 0.3 nM (mean +/- S.E.M., n = 3)...

journal_title：European journal of pharmacology

authors： Entzeroth M,Braunger H,Eberlein W,Engel W,Rudolf K,Wienen W,Wieland HA,Willim KD,Doods HN

更新日期：1995-05-24 00:00:00

abstract：:We tested the hypothesis that relaxation of the rat mesenteric artery in response to insulin is mediated by K(+) channels. Two concentrations of insulin (10 and 100 mU/ml) induced relaxation of the artery by 6+/-1%, 24+/-3% (mean+/-S.E.M.). Denudation of the endothelium or precontraction by KCl (30 mM), clotrimazole (...

journal_title：European journal of pharmacology

authors： Iida S,Taguchi H,Watanabe N,Kushiro T,Kanmatsuse K

更新日期：2001-01-05 00:00:00