Interleukin 2 activity of human intestinal mucosa mononuclear cells. Decreased levels in inflammatory bowel disease.

abstract：BACKGROUND & AIMS:New serologic markers of inflammatory bowel disease may be useful for differentiating between Crohn's disease and ulcerative colitis and for disease stratification. We profiled sugar-binding antibodies to identify novel antiglycan antibodies that may be associated with inflammatory bowel disease. MET...

journal_title：Gastroenterology

authors： Dotan I,Fishman S,Dgani Y,Schwartz M,Karban A,Lerner A,Weishauss O,Spector L,Shtevi A,Altstock RT,Dotan N,Halpern Z

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND & AIMS:Foodborne illness affects 15% of the US population each year, and is a risk factor for irritable bowel syndrome (IBS). We evaluated risk of, risk factors for, and outcomes of IBS after infectious enteritis. METHODS:We performed a systematic review of electronic databases from 1994 through August 31, ...

journal_title：Gastroenterology

authors： Klem F,Wadhwa A,Prokop LJ,Sundt WJ,Farrugia G,Camilleri M,Singh S,Grover M

更新日期：2017-04-01 00:00:00

abstract：:This study investigated the relationships of the serum markers of fibrogenesis and basement membrane formation to the clinical and morphological severity of alcoholic liver disease and to the degree of alcohol abuse. The concentrations of the aminoterminal propeptide of type III collagen, type IV collagen, and laminin...

journal_title：Gastroenterology

authors： Niemelä O,Risteli J,Blake JE,Risteli L,Compton KV,Orrego H

更新日期：1990-06-01 00:00:00

abstract：:The human gut microbiome is a collection of bacteria, protozoa, fungi, and viruses that coexist in our bodies and are essential in protective, metabolic, and physiologic functions of human health. Gut dysbiosis has traditionally been linked to increased risk of infection, but imbalances within the intestinal microbial...

journal_title：Gastroenterology

authors： Haran JP,McCormick BA

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatitis B virus (HBV) and hepatitis C virus (HCV) can be transmitted during administration of intravenous anesthesia when medication vials are used for multiple patients using incorrect technique. We investigated an outbreak of acute HBV and HCV infections among patients who received anesthesia duri...

journal_title：Gastroenterology

authors： Gutelius B,Perz JF,Parker MM,Hallack R,Stricof R,Clement EJ,Lin Y,Xia GL,Punsalang A,Eramo A,Layton M,Balter S

更新日期：2010-07-01 00:00:00

abstract：:Basolateral, brush-border, and Golgi-enriched subcellular membrane fractions, prepared from homogenates of rat small intestinal mucosa obtained by scraping, had unusually high concentrations of nonesterified fatty acids. These fatty acids appear to be responsible for the large amount of calcium binding, an effect that...

journal_title：Gastroenterology

authors： Walters JR,Horvath PJ,Weiser MM

更新日期：1986-07-01 00:00:00

abstract：BACKGROUND & AIMS:Hemosiderosis may have a detrimental effect on some chronic liver diseases. The aim of this study was to determine the prevalence and diagnostic implications of hemosiderosis in cirrhosis. METHODS:Tissue iron in 447 cirrhotic livers was studied histologically and chemically. RESULTS:Positive iron st...

journal_title：Gastroenterology

authors： Ludwig J,Hashimoto E,Porayko MK,Moyer TP,Baldus WP

更新日期：1997-03-01 00:00:00

abstract：:A numerically important group of patients with functional gastrointestinal disorders have chronic symptoms that can be attributed to the gastroduodenal region. Based on the consensus opinion of an international panel of clinical investigators who reviewed the available evidence, a classification of the functional gast...

journal_title：Gastroenterology

authors： Tack J,Talley NJ,Camilleri M,Holtmann G,Hu P,Malagelada JR,Stanghellini V

更新日期：2006-04-01 00:00:00

abstract：:This paper describes the clinical management of 204 patients with Crohn's disease involving the colon who have been reviewed regularly for many years. The results have been analyzed to define the morbidity, mortality, and long term prognosis of the disorder. Despite a high morbidity, the long term prognosis is good. A...

journal_title：Gastroenterology

authors： Allan R,Steinberg DM,Williams JA,Cooke WT

更新日期：1977-10-01 00:00:00

abstract：BACKGROUND & AIMS:Rotavirus infection is a leading cause of morbidity and mortality in children younger than 5 years of age. Current treatment options are limited. We assessed the efficacy of a llama-derived, heavy-chain antibody fragment called anti-rotavirus protein (ARP1), in modifying the severity and duration of d...

journal_title：Gastroenterology

authors： Sarker SA,Jäkel M,Sultana S,Alam NH,Bardhan PK,Chisti MJ,Salam MA,Theis W,Hammarström L,Frenken LG

更新日期：2013-10-01 00:00:00

abstract：:Celiac sprue and Crohn's disease have very rarely been documented in the same patient. We report a case involving an adolescent male with known Crohn's disease who had extreme wasting, growth retardation, intractable diarrhea, and delay in development of secondary sexual characteristics. Peroral jejunal biopsy showed ...

journal_title：Gastroenterology

authors： Euler AR,Ament ME

更新日期：1977-04-01 00:00:00

abstract：BACKGROUND & AIMS:Entecavir demonstrated superior benefit to lamivudine at 48 weeks in nucleoside-naive patients with hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (CHB). We evaluated continued entecavir and lamivudine treatment through 96 weeks. METHODS:709 HBeAg-positive CHB patients were randomized to ...

journal_title：Gastroenterology

authors： Gish RG,Lok AS,Chang TT,de Man RA,Gadano A,Sollano J,Han KH,Chao YC,Lee SD,Harris M,Yang J,Colonno R,Brett-Smith H

更新日期：2007-11-01 00:00:00

abstract：:The importance of cholecystectomy as a risk factor for colorectal cancer was analyzed in an historical cohort study covering 16,773 cases during 11-14 years completed after operation. The observed number of colorectal cancers (130) was lower than the expected 153.5 [relative risk (RR) = 0.85]. For cancer of the colon,...

journal_title：Gastroenterology

authors： Adami HO,Meirik O,Gustavsson S,Nyrén O,Krusemo UB

更新日期：1983-10-01 00:00:00

abstract：:Disordered gustatory acuity was demonstrated in 22 patients with acute viral hepatitis and in 16 patients with chronic liver disease utilizing subjective responses and objective measurements of detection and recognition thresholds and scaling for NaCl, sucrose, HCl, and urea. In patients with early hepatitis and those...

journal_title：Gastroenterology

authors： Smith FR,Henkin RI,Dell RB

更新日期：1976-04-01 00:00:00

abstract：BACKGROUND & AIMS:Intrapancreatic activation of digestive enzymes is a key event in the parenchymal cell injury of pancreatitis. We hypothesized that neutrophils recruited to the pancreas during pancreatitis may contribute to such activation. METHODS:To cause experimental pancreatitis, rats and mice were treated with ...

journal_title：Gastroenterology

authors： Gukovskaya AS,Vaquero E,Zaninovic V,Gorelick FS,Lusis AJ,Brennan ML,Holland S,Pandol SJ

更新日期：2002-04-01 00:00:00

abstract：:Histologic or ultrastructural evidence of the ability of sucralfate to protect the gastric mucosa against ethanol injury is lacking. Therefore we analyzed morphologic and functional changes in the mucosa of 120 rats receiving, intragastrically, 2 ml of either sucralfate 500 mg/kg body wt or a control solution and 1 h ...

journal_title：Gastroenterology

authors： Hollander D,Tarnawski A,Krause WJ,Gergely H

更新日期：1985-01-01 00:00:00

abstract：:In a series of in vitro studies, both the soluble (plasmatic) coagulation system and the cellular (platelet-mediated) aspect of coagulation were shown to be extremely sensitive to relatively minor increases in hydrogen ion concentration. All studies became abnormal at pH 6.8. At pH 6.4, assays of the intrinsic and ext...

journal_title：Gastroenterology

authors： Green FW Jr,Kaplan MM,Curtis LE,Levine PH

更新日期：1978-01-01 00:00:00

abstract：BACKGROUND & AIMS:Intestinal fibrosis and stricture formation are serious complications of Crohn's disease, often requiring surgical intervention. Unfortunately, the mechanisms underlying intestinal fibrosis development are poorly understood, in part because of the lack of relevant animal models. Here, we present a nov...

journal_title：Gastroenterology

authors： Grassl GA,Valdez Y,Bergstrom KS,Vallance BA,Finlay BB

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND & AIMS:Cellular and molecular mechanisms of esophageal ulcer healing remain unexplored. We studied the sequential cellular events and the expression of keratinocyte growth factor (KGF) and its receptor (KGF-R) during the healing of experimental esophageal ulcers. METHODS:Esophageal ulcers were produced in r...

journal_title：Gastroenterology

authors： Baatar D,Kawanaka H,Szabo IL,Pai R,Jones MK,Kitano S,Tarnawski AS

更新日期：2002-02-01 00:00:00

abstract：:The effect of total-body ionizing radiation on the digestive tract is dose-dependent and time-dependent. At low doses (1.5 Gy), one observes only a short prodromal syndrome consisting of nausea, vomiting, and gastric suppression. At doses greater than 6 Gy, the prodromal syndrome is more marked, and it is followed aft...

journal_title：Gastroenterology

authors： Dubois A,Walker RI

更新日期：1988-08-01 00:00:00

abstract：:We have developed an isolated intestinal cell system to study the regulation of cholecystokinin release. Enzymatically dispersed canine jejunal mucosal cells were separated by counterflow elutriation to enrich cholecystokinin content 20-fold. Release of cholecystokinin from freshly isolated cells was determined by rad...

journal_title：Gastroenterology

authors： Barber DL,Walsh JH,Soll AH

更新日期：1986-09-01 00:00:00

abstract：:Evidence-based medicine combines clinical expertise and the best available evidence from systematic research to aid decision making in patient care. Levels of evidence can be graded from I to V, with level I, the strongest, coming from large randomized controlled trials (RCTs). When a definitive RCT has not been perfo...

journal_title：Gastroenterology

authors： Howden CW

更新日期：1997-12-01 00:00:00

abstract：BACKGROUND & AIMS:The I1307K allele of the APC gene has been shown to confer a modestly elevated risk of colorectal cancer in the Ashkenazi Jewish population (relative risk, 1.5-1.7). However, it is unclear whether the alteration predisposes to adenomas and whether the genetic information can be used in clinical practi...

journal_title：Gastroenterology

authors： Stern HS,Viertelhausen S,Hunter AG,O'Rourke K,Cappelli M,Perras H,Serfas K,Blumenthall A,Dewar D,Baumann E,Lagarde AE

更新日期：2001-02-01 00:00:00

abstract：:An in vitro fecal incubation system was used to demonstrate how lactulose influences ammonia metabolism in the colon. Lactulose and other fermentable substrates (glucose, mannitol, and sorbitol), pH and organic acid were varied independently so that their different effects could be determined. Fermentable substrate ca...

journal_title：Gastroenterology

authors： Vince A,Killingley M,Wrong OM

更新日期：1978-03-01 00:00:00

abstract：BACKGROUND & AIMS:Eosinophilic esophagitis (EoE) is a chronic inflammatory disease of the esophagus characterized by dense tissue eosinophilia; it is refractory to proton pump inhibitor therapy. EoE affects all age groups but most frequently individuals between 20 and 50 years of age. Topical corticosteroids are effect...

journal_title：Gastroenterology

authors： Straumann A,Conus S,Degen L,Felder S,Kummer M,Engel H,Bussmann C,Beglinger C,Schoepfer A,Simon HU

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND & AIMS:Immune-nonimmune cell interactions modulate mucosal immunity. We investigated the expression of adhesion molecules by intestinal fibroblasts, the effect of immune cell-derived factor on fibroblast binding of T cells, and the consequences of interfering with adhesion molecule expression on fibroblast-T...

journal_title：Gastroenterology

authors： Musso A,Condon TP,West GA,De La Motte C,Strong SA,Levine AD,Bennett CF,Fiocchi C

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND & AIMS:In cirrhosis, increased amounts of circulating hormones such as angiotensin II may induce vascular tone changes and alter vascular smooth muscle cell (VSMC) function and growth. The aim of this study was to investigate the growth of aortic VSMCs from cirrhotic rats with or without the addition of angi...

journal_title：Gastroenterology

authors： Tazi KA,Moreau R,Cailmail S,Gadano A,Trombino C,Lebrec D

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND & AIMS:Biliary epithelial cells (BECs) are considered to be a source of regenerating hepatocytes when hepatocyte proliferation is compromised. However, there is still controversy about the extent to which BECs can contribute to the regenerating hepatocyte population, and thereby to liver recovery. To investi...

journal_title：Gastroenterology

authors： Choi TY,Ninov N,Stainier DY,Shin D

更新日期：2014-03-01 00:00:00

abstract：:Increased type III collagen deposition in all layers of the intestinal tract, including the lamina propria, is a common feature of strictures in Crohn's disease. In the present study, it was found that in comparison with fibroblasts from normal or nonstrictured but inflamed intestinal lamina propria, the fibroblasts i...

journal_title：Gastroenterology

authors： Stallmach A,Schuppan D,Riese HH,Matthes H,Riecken EO

更新日期：1992-06-01 00:00:00

abstract：BACKGROUND:Liver injury in many patients with chronic hepatitis B is sporadic and is often characterized by acute exacerbations alternating with relatively normal liver function. The aim of this study was to perform detailed serological and biochemical analysis during periods of active liver disease to better understan...

journal_title：Gastroenterology

authors： Maruyama T,Iino S,Koike K,Yasuda K,Milich DR

更新日期：1993-10-01 00:00:00