Abstract：
:A peptide hormone was extracted from the porcine right atrium following a bioassay for differential vasorelaxant effects on smooth muscle strips from aorta and renal and inferior mesenteric arteries. The isolation procedure included several steps of gel-permeation and ion-exchange chromatography, and high performance liquid chromatography. During the isolation procedure, other peptides of smaller molecular weight were also found, which, in relation to cardiodilatin-126 (CDD-126), are shorter at their N-terminal. Among these, CDD-88 has also been isolated and characterized, and has been established as a prominent member of the cardiac hormone family. The N-terminal and C-terminal segments of the 126 amino acid-containing molecule were synthesized and used to raise region-specific antibodies. The natural peptide was then localized within myoendocrine cells of the right atrium where specific atrial granules are located. Renal effects of cardiodilation were studied in conscious dogs and showed strong diuretic and natriuretic activities. According to our functional studies, cardiodilatin-126 and cardiodilatin-88 possess qualities of a significant hormone family regarding the regulation of extracellular fluid volume and blood pressure.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Forssmann WG,Birr C,Carlquist M,Christmann M,Finke R,Henschen A,Hock D,Kirchheim H,Kreye V,Lottspeich Fdoi
10.1007/BF00219856subject
Has Abstract,Author List Incompletepub_date
1984-01-01 00:00:00pages
425-30issue
3eissn
0302-766Xissn
1432-0878journal_volume
238pub_type
杂志文章abstract：:It is a well-established fact that the sympathetic, parasympathetic and enteric nervous systems are affected at early stages in Parkinson's disease (PD). However, it is not yet clarified whether the earliest pathological events preferentially occur in any of these three divisions of the autonomic nervous system (ANS)....
journal_title：Cell and tissue research
pub_type： 杂志文章,评审
doi：10.1007/s00441-018-2851-9
更新日期：2018-07-01 00:00:00
abstract：:Colonies of the ascidian Botryllus schlosseri undergo recurrent generation changes in which adult zooids are gradually resorbed and replaced by new blastogenic generations. During these periods, known as take-over phases, programmed cell death, which, on the basis of morphological analysis is ascribed to apoptosis, oc...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-003-0738-9
更新日期：2003-06-01 00:00:00
abstract：:Mole rat bone marrow cells and peritoneal eosinophils are used to study granule morphological maturation by quantitative microscopy. The bulk eosinophil granule content is pre-stored in unique granular structures known as crystalloid or secondary granules. Mole rat eosinophil granules exhibit the basic structure of an...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-015-2189-5
更新日期：2015-10-01 00:00:00
abstract：:Endothelins (ET) are a family of vasoactive peptides that act via two subtypes of receptors, named ETA and ETB. ET-1 binds to both ETA and ETB, whereas the isopeptide ET-3 preferentially binds to ETB. The localization of ETA and ETB receptors in the rat adrenal gland and their involvement in the adrenal secretagogue e...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s004410050820
更新日期：1997-05-01 00:00:00
abstract：:Freeze-etch preparations of mesothelial cells taken from the peritoneum of mouse reveal the presence of vesicles invaginating the apical and the basal cell surfaces. These vesicles are scarcely seen within the cytoplasm. Long tortuous tubular profiles extend for considerable distance within the cytoplasm and are frequ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00219271
更新日期：1976-10-01 00:00:00
abstract：:Nitric oxide and various neuropeptides in the myenteric plexus regulate esophageal motility. We sought colocalization of nitric oxide synthase and neuropeptides in frozen sections of mid-portion of smooth-muscled opossum esophagus using NADPH-diaphorase activity to mark the synthase and immunoreactivity to detect pept...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00331374
更新日期：1994-12-01 00:00:00
abstract：:Although several studies have shown a dysregulation of microRNA (miRNA) expression profiles in cutaneous melanoma, there has been little research on the miRNA machinery itself. In this study, we investigated the mRNA expression profiles of different miRNA machinery components in primary cutaneous malignant melanoma (P...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-012-1446-0
更新日期：2012-10-01 00:00:00
abstract：:The pineal gland structure and ultrastructure in the Northern (Blarina brevicauda) and Southern short-tailed shrew (Blarina carolinensis) are described by light and electron microscopy. Results observed were similar to other mammals of Insectivora described previously, specifically, the hedgehog (Erinaceus europaeus) ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-018-2897-8
更新日期：2018-12-01 00:00:00
abstract：:Sigma receptor 1 (σR1), a non-opiate transmembrane protein located on endoplasmic reticulum (ER) and mitochondrial membranes, is considered to be a molecular chaperone. Marked protection against cell death has been observed when ligands for σR1 have been used in in vitro and in vivo models of retinal cell death. Mice ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-013-1774-8
更新日期：2014-04-01 00:00:00
abstract：:The development of the canine proximal colon from the completion of organogenesis through 43 days after birth was studied using light microscopy, immunofluorescence and electron microscopy. During this period the tunica muscularis increased in thickness from 42+/-6 microm in animals midway through the gestation period...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00319136
更新日期：1995-10-01 00:00:00
abstract：:Kidneys of 2 to 10 day-old rats of Wistar and Sprague-Dawley strains were fixed with glutaraldehyde by retrograde vascular perfusion and then prepared for observation in TEM and SEM. In addition methacrylate casts of differentiating glomerular capillaries were examined by SEM. Although the glomerular vascular pattern ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00233959
更新日期：1980-01-01 00:00:00
abstract：:The distribution of neuronal elements immunoreactive for gamma-aminobutyric acid (GABA) and glycine in the cochlear nucleus of the mustached bat Pteronotus parnellii has been studied by means of the postembedding technique on serial semithin sections. Our goal has been to identify similarities and differences in the o...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s004410050773
更新日期：1997-02-01 00:00:00
abstract：:Electron-microscopic studies of lymphoid tissues from bovine fetuses and from calves disclosed a non-lymphoid cell type in the thymus-dependent zones of secondary lymphoid tissues and in the thymus that is distinguishable from reticulum cells, epithelial and endothelial cells, and macrophages. Based on morphological a...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00213735
更新日期：1984-01-01 00:00:00
abstract：:The fine structure of the ventrolateral and dorsomedial subdivisions of the ventromedial nucleus (VMN) of the hypothalamus was examined in ovariectomized/control and ovariectomized/estrogen-treated rats to compare neurons of these areas to other neurons (specifically the ventrolateral thalamus), and to determine the e...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00219357
更新日期：1981-01-01 00:00:00
abstract：:The immunocytochemical localization of bovine oviduct-specific glycoproteins was investigated by light and electron microscopy. Using monoclonal antibodies (MAbs) specific for bovine oviductal glycoproteins, 3 regions (fimbriae, ampulla, and isthmus) of the epithelium in the bovine oviduct we studied during the follic...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00327983
更新日期：1993-10-01 00:00:00
abstract：:Loss of wild-type p53 activity is thought to be a major predictor of failure to respond to radiotherapy and chemotherapy in various human cancers. This assumption is largely based on some cell-death studies in p53-knockout mice and on correlations of p53 status assessed by immunochemistry or single-strand conformation...
journal_title：Cell and tissue research
pub_type： 杂志文章,评审
doi：10.1007/s004410051072
更新日期：1998-06-01 00:00:00
abstract：:Periodontal regeneration requires the coordinated movement and differentiation of several cell types in order to re-establish the cementum, periodontal ligament (PDL), and alveolar bone. Cells in culture are often used as model systems for mature tissues, although they may represent expanded progenitor cell population...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-006-0282-5
更新日期：2007-01-01 00:00:00
abstract：:The ultrastructure of adult male rat pinealocytes was studied after orchidectomy and orchidectomy followed by LH-RH administration. Castration causes an increased development of the rough endoplasmic reticulum and the Golgi apparatus as well as an increase in the number of lipid droplets and lysosomes. The changes aft...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00219145
更新日期：1976-04-02 00:00:00
abstract：:Our findings suggest that nitric oxide (NO) acts as peripheral neuromodulator in locusts, in which it is commonly co-localized with RF-like peptide in neurosecretory cells. We also present the first evidence for NO as a cardio-regulator in insects. Putative NO-producing neurones were detected in locust pre-genital fre...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-006-0188-2
更新日期：2006-08-01 00:00:00
abstract：:Serotonin immunoreactivity was localized in hearts of the opisthobranch gastropod, Aplysia californica (sea hare) and several species of bivalve mollusks, the heterodonts, Mercenaria mercenaria (quahog or cherry stone clam), Protothaca staminea (little neck clam), and the pteriomorphs, Hinnites multirugosus (rock scal...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00353897
更新日期：1992-09-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00219416
更新日期：1976-07-30 00:00:00
abstract：:Dorsal root ganglia of chick embryos were cultured for one to four weeks on Maximow-slides. Puromycin was added to cultures for a pulse of 30' in a dose of 100 mug/ml medium. Particular interest was given to the ultrastructural features of the glia-neuron relations. Puromycin caused a shrinkage of the glial processes ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00225762
更新日期：1975-07-23 00:00:00
abstract：:The excretory system of Macrobiotus richtersi consists of one dorsal and two lateral components and shows a high degree of structural complexity. In each of these a tricellular external lobe and a column can be distinguished, the two parts being connected distally. The surface of the lobe cells is increased by deep ba...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00239339
更新日期：1980-01-01 00:00:00
abstract：:In order to compare the functional state of the anterior pituitary of spontaneously hypertensive rats (SHR) with that of nonmotensive Wistar Kyoto rats (WKR), the anterior pituitary was examined by morphometry and autoradiography at the level of electron microscopy. The relative number and the relative volume of thyro...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00237005
更新日期：1979-10-01 00:00:00
abstract：:The distribution and synaptic connections of the indoleamine-accumulating neurons in the retinae of the goldfish and carp were studied by means of fluorescence and electron microscopy. The indoleamine-accumulating neurons were visualized after intravitreal injection and uptake of the indoleamine 5,6-dihydroxytryptamin...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
abstract：:The surface coat of the electrocyte of the main electric organ of Electrophorus electricus was studied using cytochemical methods (periodic acid-silver methanamine, periodic acid-chromic acid-silver methenamine, periodic acid-thiosemicarbazide-silver proteinate, Concanavalin A - horseradish peroxidase, ruthenium red, ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00226622
更新日期：1977-09-26 00:00:00
abstract：:The larval stage of Polypodium hydriforme is planuliform and parasitic inside the growing oocytes of acipenserid fishes. The larva has inverted germ layers and a special envelope, the trophamnion, surrounding it within the host oocyte. The trophamnion is a giant unicellular provisory structure derived from the second ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00237977
更新日期：1980-01-01 00:00:00
abstract：:The supraependymal cells (SEC) are a normal component of the wall of the cerebral ventricles. In the hypothalamic area of the third ventricle they are restricted, in healthy animals, to the ependymal projection of the hypophyseotropic area. Here the SEC show great polymorphism. In addition to bipolar, multipolar and s...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00215308
更新日期：1976-05-13 00:00:00
abstract：:Identified dorsal unpaired median (DUM) neurones of the locust Locusta migratoria were stained intracellularly with large amounts of cobalt to reveal their extensive peripheral branching patterns. Two neurones of the suboesophageal ganglion were studied as well as several neurones of thoracic ganglia. The peripheral b...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s004410050970
更新日期：1997-12-01 00:00:00
abstract：:The burrower bug Scaptocoris castanea is an important soybean and pasture pest in Brazil, with an underground habit feeding directly on the sap of the roots. Underground habit hinders control and knowledge of the biology and physiology of this pest. This study describes the anatomy, histology, ultrastructure and symbi...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-020-03197-7
更新日期：2020-11-01 00:00:00
