Association of fibril structure formation with cell surface properties of Yersinia enterocolitica.

abstract：:Cysteine proteases, including Arg-gingipain of Porphyromonas gingivalis, have been implicated as important virulence factors in periodontal diseases. These enzymes are also involved in the hemagglutinating activity of the organisms. In order to determine the role of proteases in the colonization of the gingival margin...

journal_title：Infection and immunity

authors： Tokuda M,Duncan M,Cho MI,Kuramitsu HK

更新日期：1996-10-01 00:00:00

abstract：:In order to construct an effector strain for the replacement therapy of dental caries, we wished to combine the properties of low-level acid production and high-level colonization potential in a strain of Streptococcus mutans. To this end, we made a deletion in the lactate dehydrogenase (LDH) gene cloned from the bact...

journal_title：Infection and immunity

authors： Hillman JD,Chen A,Duncan M,Lee SW

更新日期：1994-01-01 00:00:00

abstract：:Borrelia burgdorferi, the bacterium that causes Lyme disease, has a unique segmented genome consisting of numerous linear and circular plasmids and a linear chromosome. Many of these genetic elements have been found to encode factors critical for B. burgdorferi to complete the infectious cycle. However, several plasmi...

journal_title：Infection and immunity

authors： Dulebohn DP,Bestor A,Rosa PA

更新日期：2013-08-01 00:00:00

abstract：:We report on the identification of a surface-exposed, highly conserved, immunogenic nontypeable Haemophilus influenzae (NTHi) protein, which elicits cross-reactive bactericidal antibodies against NTHi. The protein was extracted from NTHi strain P860295 with KSCN and purified; it migrated as a single band on a sodium d...

journal_title：Infection and immunity

authors： Zagursky RJ,Ooi P,Jones KF,Fiske MJ,Smith RP,Green BA

更新日期：2000-05-01 00:00:00

abstract：:The surface coat of Trypanosoma brucei, formed by about 10(7) molecules of the membrane-form variant surface glycoprotein (mfVSG) per cell, is generally considered to constitute a barrier against the access of antibodies directed to invariant surface proteins. The recent characterization of two invariant surface glyco...

journal_title：Infection and immunity

authors： Ziegelbauer K,Overath P

更新日期：1993-11-01 00:00:00

abstract：:The precise role of Leishmania glycoconjugate molecules including phosphoglycans (PGs) and lipophosphoglycan (LPG) on host cellular responses is still poorly defined. Here, we investigated the interaction of Leishmania major LPG2 null mutant (lpg2(-)), which lacks both PGs and LPG, with dendritic cells (DCs) and the s...

journal_title：Infection and immunity

authors： Liu D,Kebaier C,Pakpour N,Capul AA,Beverley SM,Scott P,Uzonna JE

更新日期：2009-08-01 00:00:00

abstract：:Vibrio parahaemolyticus is the leading cause of bacterial seafood-borne gastroenteritis worldwide, yet little is known about how this pathogen colonizes the human intestine. The alternative sigma factor RpoN/sigma-54 is a global regulator that controls flagellar synthesis, as well as a wide range of nonflagellar genes...

journal_title：Infection and immunity

authors： Whitaker WB,Richards GP,Boyd EF

更新日期：2014-02-01 00:00:00

abstract：:Antisera were raised in rabbits with acid-treated Re mutant bacteria from Salmonella minnesota and Escherichia coli and tested in a passive hemolysis assay with di- and monophosphorylated free lipid A of E. coli (LipA-Ac and LipA-HCl, respectively) coated onto sheep erythrocytes. Depending on the acid used to prepare ...

journal_title：Infection and immunity

authors： Brade L,Brade H

更新日期：1985-06-01 00:00:00

abstract：:A cytotoxigenic Clostridium difficile strain that fails to produce toxin A but causes hemorrhage and bloody fluid accumulation in ligated ileal loops of rabbits and hemorrhage and diarrhea in hamsters is described. The lack of reaction of DNA from this strain in hybridization studies with a toxin A gene-specific 4.5-k...

journal_title：Infection and immunity

authors： Borriello SP,Wren BW,Hyde S,Seddon SV,Sibbons P,Krishna MM,Tabaqchali S,Manek S,Price AB

更新日期：1992-10-01 00:00:00

abstract：:The Syrian golden hamster (Mesocricetus auratus) is uniquely susceptible to a variety of intracellular pathogens and is an excellent model for a number of human infectious diseases. The molecular basis for this high level of susceptibility is unknown, and immunological studies related to this model have been limited b...

journal_title：Infection and immunity

authors： Melby PC,Tryon VV,Chandrasekar B,Freeman GL

更新日期：1998-05-01 00:00:00

abstract：:CmeABC functions as a multidrug efflux pump contributing to the resistance of Campylobacter to a broad range of antimicrobials. In this study, we examined the role of CmeABC in bile resistance and its contribution to the adaptation of Campylobacter jejuni in the intestinal tract of the chicken, a natural host and a ma...

journal_title：Infection and immunity

authors： Lin J,Sahin O,Michel LO,Zhang Q

更新日期：2003-08-01 00:00:00

abstract：:Mice were infected with 170 Trichinella spiralis larvae, and their blood clearance of carbon particles was studied 4, 7, 13, 32, and 135 days later and compared with that of noninfected control mice. Clearance in mice with a 4-day-old infection was comparable to that in the controls; clearances in mice with 7- and 13-...

journal_title：Infection and immunity

authors： Barriga OO

更新日期：1980-12-01 00:00:00

abstract：:The Pseudomonas aeruginosa quorum-sensing systems, las and rhl, control the production of numerous virulence factors. In this study, we have used the burned-mouse model to examine the contribution of quorum-sensing systems to the pathogenesis of P. aeruginosa infections in burn wounds. Different quorum-sensing mutants...

journal_title：Infection and immunity

authors： Rumbaugh KP,Griswold JA,Iglewski BH,Hamood AN

更新日期：1999-11-01 00:00:00

abstract：:Viral hepatitis caused by infection with murine hepatitis virus strain A59 has been shown to affect the mitotic response after partial hepatectomy in mice. Normal mice showed a delayed response, whereas nude mice did not show any response, even 5 days after partial hepatectomy. ...

journal_title：Infection and immunity

authors： Carthew P

更新日期：1981-08-01 00:00:00

abstract：:The scrub typhus 58-kilodalton (kDa) antigen (Sta58) of Rickettsia tsutsugamushi is a major protein antigen often recognized by humans infected with scrub typhus rickettsiae. A 2.9-kilobase HindIII fragment containing a complete sta58 gene was cloned in Escherichia coli and found to express the entire Sta58 antigen an...

journal_title：Infection and immunity

authors： Stover CK,Marana DP,Dasch GA,Oaks EV

更新日期：1990-05-01 00:00:00

abstract：:Borrelia burgdorferi is a causative agent of Lyme disease, the most common arthropod-borne disease in the United States. B. burgdorferi evades host immune defenses to establish a persistent, disseminated infection. Previous work showed that P66-deficient B. burgdorferi (Δp66) is cleared quickly after inoculation in mi...

journal_title：Infection and immunity

authors： Curtis MW,Hahn BL,Zhang K,Li C,Robinson RT,Coburn J

更新日期：2018-01-22 00:00:00

abstract：:Mapping vectors containing antibiotic resistance markers inserted adjacent to or within different cloned genes from Streptococcus mutans were used to determine the relative positions of these genes on the chromosome. The gtfA, ftf, and scrB genes were inserted into streptococcal mapping vector pVA891 adjacent to an Em...

journal_title：Infection and immunity

authors： Perry D,Kuramitsu HK

更新日期：1989-03-01 00:00:00

abstract：:Fusobacterium nucleatum is closely associated with human periodontal diseases and may also be a causative agent in other infections, such as pericarditis, septic arthritis, and abscesses of tonsils and liver. Initiation and outcome of infective diseases depend critically on the host cell signaling system altered by th...

journal_title：Infection and immunity

authors： Uitto VJ,Baillie D,Wu Q,Gendron R,Grenier D,Putnins EE,Kanervo A,Firth JD

更新日期：2005-02-01 00:00:00

abstract：:To determine the protective efficacy of human hyperimmune globulin to Haemophilus influenzae type b disease in an infant rat model, we compared hyperimmune globulin containing 600 mug of anti-polyribophosphate (PRP) antibody per ml to conventional immune globulin containing 66 mug of anti-PRP antibody per ml. The hype...

journal_title：Infection and immunity

authors： Ambrosino D,Schreiber JR,Daum RS,Siber GR

更新日期：1983-02-01 00:00:00

abstract：:Purified and concentrated Venezuelan equine encephalitis (VEE) virus derived from tissue cultures, rendered noninfectious by ionizing radiation with retention of in vitro serological activity, also retained a high level of immunogenicity. In mice, fluid vaccines afforded excellent protection against lethal challenge w...

journal_title：Infection and immunity

authors： Gruber J

更新日期：1971-04-01 00:00:00

abstract：:Optimal growth conditions have been established for production of heat-labile enterotoxin (LT) by both porcine and human strains of enterotoxigenic (ENT(+)) Escherichia coli. There were no unusual growth factor requirements, and some strains produced fairly high levels of LT in a basal salts medium containing 0.5% glu...

journal_title：Infection and immunity

authors： Gilligan PH,Robertson DC

更新日期：1979-01-01 00:00:00

abstract：:During the recent bioterrorism-related outbreaks, inhalational anthrax had a 45% mortality in spite of appropriate antimicrobial therapy, underscoring the need for better adjuvant therapies. The variable latency between exposure and development of disease suggests an important role for the host's innate immune respons...

journal_title：Infection and immunity

authors： Gold JA,Hoshino Y,Hoshino S,Jones MB,Nolan A,Weiden MD

更新日期：2004-03-01 00:00:00

abstract：:Chronic granulomatous disease (CGD) is a genetic disorder of NADPH oxidase in which phagocytes are defective in generating reactive oxidants. CGD patients suffer from recurrent infections and exuberant and persistent tissue granuloma formation. We hypothesized that abnormal granulomata in CGD may result from aberrant ...

journal_title：Infection and immunity

authors： Segal BH,Doherty TM,Wynn TA,Cheever AW,Sher A,Holland SM

更新日期：1999-04-01 00:00:00

abstract：:It was demonstrated that complement-coated sheep erythrocytes bind to Candida albicans cells grown in serum-free RPMI 1640 medium. Testing of purified complement components proved that iC3b and C3d were responsible for the reaction, whereas C3b and C3b-H reacted only slightly if at all. Binding occurred only to C. alb...

journal_title：Infection and immunity

authors： Heidenreich F,Dierich MP

更新日期：1985-11-01 00:00:00

abstract：:Rats kept under germfree conditions showed lower specific lysosomal enzyme activities in liver endothelial cells, but not in Kupffer cells. ...

journal_title：Infection and immunity

authors： Knook DL,Barkway C,Sleyster EC

更新日期：1981-08-01 00:00:00

abstract：:Human monocytic ehrlichiosis (HME) is caused by a tick-borne obligate intracellular pathogen of the order Rickettsiales. HME disease can range from mild to a fatal, toxic shock-like syndrome, yet the mechanisms regulating pathogenesis are not well understood. We define a central role for type I interferons (alpha inte...

journal_title：Infection and immunity

authors： Zhang Y,Thai V,McCabe A,Jones M,MacNamara KC

更新日期：2014-04-01 00:00:00

abstract：:Legionella pneumophila organisms are able to infect and multiply within the ciliated protozoan Tetrahymena pyriformis. This ability may be associated with virulence, because an attenuated strain of L. pneumophila fails to multiply within this protozoan, whereas a virulent strain increases 10,000-fold in number when co...

journal_title：Infection and immunity

authors： Fields BS,Barbaree JM,Shotts EB Jr,Feeley JC,Morrill WE,Sanden GN,Dykstra MJ

更新日期：1986-09-01 00:00:00

abstract：:The literature on chronic mucocutaneous candidiasis contains multiple reports which suggest that loss of cell-mediated immunity in this disease may be related in part to the presence of an inhibitory factor(s) present in patient plasma. One such inhibitory factor has been suggested to be mannan polysaccharide released...

journal_title：Infection and immunity

authors： Nelson RD,Herron MJ,McCormack RT,Gehrz RC

更新日期：1984-03-01 00:00:00

abstract：:Brucella abortus injected into CBA mice replicated primarily in the spleen and liver, reaching a peak bacterial count in both organs about 7 days postinfection. The organism was eliminated from the liver but declined to a chronic phase in the spleen. The infection caused hepatosplenomegaly. An influx of macrophages in...

journal_title：Infection and immunity

authors： Doyle AG,Halliday WJ,Barnett CJ,Dunn TL,Hume DA

更新日期：1992-04-01 00:00:00

abstract：:Aspergillus fumigatus produces conidia that are highly dispersable and resistant to degradation. We have sought to analyze these properties by studying the rodlets which form the outer spore coat protein. Degenerate primers based on hydrophobins in other fungi were applied to genomic DNA from A. fumigatus in PCR. A pr...

journal_title：Infection and immunity

authors： Parta M,Chang Y,Rulong S,Pinto-DaSilva P,Kwon-Chung KJ

更新日期：1994-10-01 00:00:00