Exogenous gamma and alpha/beta interferon rescues human macrophages from cell death induced by Bacillus anthracis.

abstract：:Encapsulated Streptococcus pneumoniae of serotypes 2, 9N, 14, 21, and 23F and an unencapsulated variant of type 2 pneumococci were efficiently phagocytosed by both aerobically and anaerobically incubated human leukocytes. In the presence of O2, the pneumococci rapidly lost their viability, whereas during anaerobiosis,...

journal_title：Infection and immunity

authors： Thore M,Löfgren S,Tärnvik A,Monsen T,Selstam E,Burman LG

更新日期：1985-01-01 00:00:00

abstract：:Cell-mediated immunity to herpes simplex virus type 1 (HSV-1) was assessed by a lymphocytotoxicity 51-Cr-release microassay procedure, using the MA-160 human prostatic adenoma cell line chronically infected with HSV-1 and its parent cell line as control. The specific immune release mean plus or minus standard deviatio...

journal_title：Infection and immunity

authors： Thong YH,Vincent MM,Hensen SA,Fuccillo DA,Rola-Pleszczynski M,Bellanti JA

更新日期：1975-07-01 00:00:00

abstract：:Rickettsia rickettsii and R. australis formed infectious antibody complexes when reacted with homologous convalescent serum. The addition of antiglobulin to these complexes showed neutralization of plaques proportional to the concentration of rickettsial immune serum. ...

journal_title：Infection and immunity

authors： Kenyon RH,McManus AT

更新日期：1974-05-01 00:00:00

abstract：:The population structure of the Bacillus cereus group (52 strains of B. anthracis, B. cereus, and B. thuringiensis) was investigated by sequencing seven gene fragments (rpoB, gyrB, pycA, mdh, mbl, mutS, and plcR). Most of the strains were classifiable into two large subgroups in six housekeeping gene trees but not in ...

journal_title：Infection and immunity

authors： Ko KS,Kim JW,Kim JM,Kim W,Chung SI,Kim IJ,Kook YH

更新日期：2004-09-01 00:00:00

abstract：:Borrelia burgdorferi, an agent of Lyme disease, establishes persistent infection in immunocompetent animals and humans. Although the infection in humans can be cleared by antibiotic therapy, persistence in reservoir animals is necessary for the maintenance of the bacterium in the natural reservoir host⇔tick vector inf...

journal_title：Infection and immunity

authors： LaFrance ME,Pierce JV,Antonara S,Coburn J

更新日期：2011-08-01 00:00:00

abstract：:Adherence to fibrinogen and fibronectin plays a crucial role in Staphylococcus aureus experimental endocarditis. Previous genetic studies have shown that infection and carriage isolates do not systematically differ in their virulence-related genes, including genes conferring adherence, such as clfA and fnbA. We set ou...

journal_title：Infection and immunity

authors： Ythier M,Entenza JM,Bille J,Vandenesch F,Bes M,Moreillon P,Sakwinska O

更新日期：2010-04-01 00:00:00

abstract：:Sephadex G-200 filtration was used for fractionating dengue type 2 (DEN-2)-infected suckling mouse brain (SMB) supernatant fluids. The high-molecular-weight fraction, which was eluted in the void volume, showed no increase in type specificity when tested against immune ascitic fluid to the four prototype dengue viruse...

journal_title：Infection and immunity

authors： Cornesky RA,Hammon WM,Atchison RW,Sather GE

更新日期：1972-12-01 00:00:00

abstract：:Mannan (MAN) extracted from Candida albicans 20A was investigated for its potential as an antigen in the detection of cell-mediated immunity (CMI) in vivo and in vitro and for its ability to modulate CMI when administered intravenously (i.v.). CBA/J mice were either immunized as adults by the cutaneous inoculation of ...

journal_title：Infection and immunity

authors： Domer JE,Garner RE,Befidi-Mengue RN

更新日期：1989-03-01 00:00:00

abstract：:Listeria monocytogenes, isolated from outbreaks in either human or nonhuman primate populations, was administered orally at doses ranging from 10(6) to 10(10) CFU. Four of 10 treated animals delivered stillborn infants. L. monocytogenes was isolated from fetal tissue, and the pathology was consistent with L. monocytog...

journal_title：Infection and immunity

authors： Smith MA,Takeuchi K,Brackett RE,McClure HM,Raybourne RB,Williams KM,Babu US,Ware GO,Broderson JR,Doyle MP

更新日期：2003-03-01 00:00:00

abstract：:Mucin glycoproteins are secreted in large amounts by the intestinal epithelium and constitute an efficient component of innate immune defenses to promote homeostasis and protect against enteric pathogens. In this study, our objective was to investigate how the bacterial enteropathogen Shigella flexneri, which causes b...

journal_title：Infection and immunity

authors： Sperandio B,Fischer N,Joncquel Chevalier-Curt M,Rossez Y,Roux P,Robbe Masselot C,Sansonetti PJ

更新日期：2013-10-01 00:00:00

abstract：:Legionella pneumophila, the gram-negative agent of Legionnaires' disease, possesses type IV pili and a type II protein secretion (Lsp) system, both of which are dependent upon the PilD prepilin peptidase. By analyzing multiple pilD mutants and various types of Lsp mutants as well as performing trans-complementation of...

journal_title：Infection and immunity

authors： Rossier O,Starkenburg SR,Cianciotto NP

更新日期：2004-01-01 00:00:00

abstract：:We have previously shown that individuals infected with Chlamydia trachomatis can develop a robust antibody response to a chlamydia-secreted protein (designated chlamydial proteasome/protease-like activity factor [CPAF]). We now report that sera collected from these infected individuals neutralized the proteolytic act...

journal_title：Infection and immunity

authors： Sharma J,Dong F,Pirbhai M,Zhong G

更新日期：2005-07-01 00:00:00

abstract：:The genome of Borrelia burgdorferi, the etiologic agent of Lyme disease, is composed of a linear chromosome and more than 20 linear and circular plasmids. Typically, plasmid content analysis has been carried out by pulsed-field gel electrophoresis and confirmed by Southern hybridization. However, multiple plasmids of ...

journal_title：Infection and immunity

authors： Iyer R,Kalu O,Purser J,Norris S,Stevenson B,Schwartz I

更新日期：2003-07-01 00:00:00

abstract：:Smoking is associated with increased susceptibility to tuberculosis and influenza. However, little information is available on the mechanisms underlying this increased susceptibility. Mice were left unexposed or were exposed to cigarette smoke and then infected with Mycobacterium tuberculosis by aerosol or influenza A...

journal_title：Infection and immunity

authors： Feng Y,Kong Y,Barnes PF,Huang FF,Klucar P,Wang X,Samten B,Sengupta M,Machona B,Donis R,Tvinnereim AR,Shams H

更新日期：2011-01-01 00:00:00

abstract：:A gene, dmcA, expressing a methyl-accepting chemotaxis protein (MCP) from the oral spirochete Treponema denticola has been characterized. The gene was initially identified as an open reading frame immediately upstream from the previously characterized prtB protease gene of strain ATCC 35405. Nucleotide sequencing of t...

journal_title：Infection and immunity

authors： Kataoka M,Li H,Arakawa S,Kuramitsu H

更新日期：1997-10-01 00:00:00

abstract：:Although excystation is crucial to the initiation of infection by Giardia lamblia, little is known about the regulation of this important process. We have been able to reliably induce excystation in vitro by mimicking cyst passage through the stomach and upper small intestine by the exposure of in vitro-derived cysts ...

journal_title：Infection and immunity

authors： Meng TC,Hetsko ML,Gillin FD

更新日期：1996-06-01 00:00:00

abstract：:This study assessed the effect of periodontal therapy on specific serum antibody concentration, expressed as titer, and antibody binding strength, expressed as relative avidity. The immune responses to Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans were investigated. Antibody titer was assayed by en...

journal_title：Infection and immunity

authors： Mooney J,Adonogianaki E,Riggio MP,Takahashi K,Haerian A,Kinane DF

更新日期：1995-09-01 00:00:00

abstract：:Botulinum neurotoxins (BoNTs) and tetanus toxin (TeNT) are the most potent toxins for humans and elicit unique pathologies due to their ability to traffic within motor neurons. BoNTs act locally within motor neurons to elicit flaccid paralysis, while retrograde TeNT traffics to inhibitory neurons within the central ne...

journal_title：Infection and immunity

authors： Zuverink M,Chen C,Przedpelski A,Blum FC,Barbieri JT

更新日期：2015-07-01 00:00:00

abstract：:Helicobacter pylori mutants devoid of urease activity fail to colonize the gastric mucosa of mice; however, the effect of decreased levels of urease on colonization has not been examined. The nixA gene, required for full urease activity, encodes a cytoplasmic membrane nickel transporter that imports nickel ions and le...

journal_title：Infection and immunity

authors： Nolan KJ,McGee DJ,Mitchell HM,Kolesnikow T,Harro JM,O'Rourke J,Wilson JE,Danon SJ,Moss ND,Mobley HL,Lee A

更新日期：2002-02-01 00:00:00

abstract：:Inflammatory cytokines play an important role in human immune responses to malarial disease. However, the role of these mediators in disease pathogenesis, and the relationship between host protection and injury remains unclear. A total of 248 cases of severe Plasmodium falciparum malaria among children aged 3 months t...

journal_title：Infection and immunity

authors： Lyke KE,Burges R,Cissoko Y,Sangare L,Dao M,Diarra I,Kone A,Harley R,Plowe CV,Doumbo OK,Sztein MB

更新日期：2004-10-01 00:00:00

abstract：:Preexisting antivector immunity can severely compromise the ability of Salmonella enterica serovar Typhimurium live vaccines to induce protective CD8 T-cell frequencies after type III secretion system-mediated heterologous protein translocation in orally immunized mice. To circumvent this problem, we injected CpG DNA ...

journal_title：Infection and immunity

authors： Berchtold C,Panthel K,Jellbauer S,Köhn B,Roider E,Partilla M,Heesemann J,Endres S,Bourquin C,Rüssmann H

更新日期：2009-12-01 00:00:00

abstract：:Internalization of Staphylococcus aureus in bovine endothelial cells (BEC) is increased by tumor necrosis factor alpha stimulation and NF-κB activation. Because the phosphoinositide-3-kinase (PI3K)-Akt signaling pathway also modulates NF-κB activity, we considered whether the internalization of S. aureus by BEC is ass...

journal_title：Infection and immunity

authors： Oviedo-Boyso J,Cortés-Vieyra R,Huante-Mendoza A,Yu HB,Valdez-Alarcón JJ,Bravo-Patiño A,Cajero-Juárez M,Finlay BB,Baizabal-Aguirre VM

更新日期：2011-11-01 00:00:00

abstract：:Pneumolysin is an important virulence factor of Streptococcus pneumoniae, interacting with the membranes of host cells to elicit a multitude of inflammatory responses. We used cDNA microarrays to identify genes which are responsive to S. pneumoniae in a pneumolysin-dependent and -independent fashion. The THP-1 human m...

journal_title：Infection and immunity

authors： Rogers PD,Thornton J,Barker KS,McDaniel DO,Sacks GS,Swiatlo E,McDaniel LS

更新日期：2003-04-01 00:00:00

abstract：:The chromosomal iroBCDEN gene cluster first described for Salmonella enterica is involved in the uptake of catecholate-type siderophore compounds. An orthologous gene cluster has recently been detected in Escherichia coli strains which cause extraintestinal disease. This E. coli iroBCDEN gene cluster has an impact on ...

journal_title：Infection and immunity

authors： Sorsa LJ,Dufke S,Heesemann J,Schubert S

更新日期：2003-06-01 00:00:00

abstract：:Streptococcus pneumoniae is a major cause of pneumonia and meningitis. Airway colonization is a necessary precursor to disease, but little is known about how the bacteria establish and maintain colonization. Carbohydrates are required as a carbon source for pneumococcal growth and, therefore, for colonization. Free ca...

journal_title：Infection and immunity

authors： Marion C,Burnaugh AM,Woodiga SA,King SJ

更新日期：2011-03-01 00:00:00

abstract：:Groups of specific pathogen-free Hartley strain guinea pigs were vaccinated with viable Mycobacterium bovis BCG and maintained on isocaloric purified diets containing either 30 or 10% protein (ovalbumin) combined with either 50 ppm (microgram/g) or no added zinc. Seven weeks later the guinea pigs were skin tested with...

journal_title：Infection and immunity

authors： McMurray DN,Yetley EA

更新日期：1983-02-01 00:00:00

abstract：:To assess the relationship between the within-host diversity of malaria infections and the susceptibility of the host to subsequent infection, we genotyped 60 children's successive infections from birth through 3 years of life. MSP-1 Block2 genotypes were used to estimate the complexity of infection (COI). Malaria tra...

journal_title：Infection and immunity

authors： Branch OH,Takala S,Kariuki S,Nahlen BL,Kolczak M,Hawley W,Lal AA

更新日期：2001-12-01 00:00:00

abstract：:Cytokine mRNA expression in biopsies of Mycobacterium ulcerans-infected human tissue was investigated using real-time PCR, and the findings were correlated with the clinical stages of disease and histopathologies. A broad range of cytokine mRNAs were detected in 16 early nodules and 28 late-stage ulcers, including tho...

journal_title：Infection and immunity

authors： Phillips R,Horsfield C,Mangan J,Laing K,Etuaful S,Awuah P,Nyarko K,Osei-Sarpong F,Butcher P,Lucas S,Wansbrough-Jones M

更新日期：2006-05-01 00:00:00

abstract：:A gene bank of group A Streptococcus strain Manfredo (M protein serotype 5) was constructed with a bacteriophage lambda vector-Escherichia coli K-12 host system and screened by immunoblotting hybrid phage plaques with antisera raised to purified pep M5 (serotype 5 M protein fragment released from the streptococcal cel...

journal_title：Infection and immunity

authors： Kehoe MA,Poirier TP,Beachey EH,Timmis KN

更新日期：1985-04-01 00:00:00

abstract：:Pathogenicities of 10 temperature-sensitive mutants of Venezuelan encephalitis virus were studied using the hamster model of human virulence. The parental strain and nine of the temperature-sensitive mutants produced lethal infections in hamsters. Strain ts 126 showed reduced hamster virulence. Deaths with the lethal ...

journal_title：Infection and immunity

authors： Krieger JN,Scherer WF,Wiebe ME,Pancake BA,Harsanyi ZP

更新日期：1979-09-01 00:00:00