Sustained effects of brief daily stress (fighting) upon brain and adrenal catecholamines and adrenal spleen, and heart weights of mice.

abstract：:The cis-acting regulatory sequence of transcription from long terminal repeats (LTRs) of human T-cell leukemia virus type I and type II (HTLV-I and HTLV-II), which is essential for action of the virally encoded trans-acting transcriptional factor(s) designated pX(s), in HTLV-I and -II was identified. Deletion of most ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shimotohno K,Takano M,Teruuchi T,Miwa M

更新日期：1986-11-01 00:00:00

abstract：:The current study identifies CCR8+ regulatory T cells (Treg cells) as drivers of immunosuppression. We show that in human peripheral blood cells, more than 30% of Treg up-regulate CCR8 following activation in the presence of CCL1. This interaction induces STAT3-dependent up-regulation of FOXp3, CD39, IL-10, and granzy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barsheshet Y,Wildbaum G,Levy E,Vitenshtein A,Akinseye C,Griggs J,Lira SA,Karin N

更新日期：2017-06-06 00:00:00

abstract：:The origin of vertebrate eyes is still enigmatic. The "frontal eye" of amphioxus, our most primitive chordate relative, has long been recognized as a candidate precursor to the vertebrate eyes. However, the amphioxus frontal eye is composed of simple ciliated cells, unlike vertebrate rods and cones, which display more...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vopalensky P,Pergner J,Liegertova M,Benito-Gutierrez E,Arendt D,Kozmik Z

更新日期：2012-09-18 00:00:00

abstract：:Na(+)-channel inactivation is proposed to occur by binding of an intracellular inactivation gate to a hydrophobic inactivation gate receptor in the intracellular mouth of the pore. Amino acid residues in transmembrane segment S6 of domain IV (IVS6) that are critical for fast inactivation were identified by alanine-sca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McPhee JC,Ragsdale DS,Scheuer T,Catterall WA

更新日期：1994-12-06 00:00:00

abstract：:We report the discovery of mammalian tribosphenic teeth from the basal Cenomanian of southwestern France that we refer to a new primitive marsupial-like form identified as a basal taxon of Marsupialiformes, a new clade recognized here to include the crown group Marsupialia and primitive stem lineages more closely rela...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vullo R,Gheerbrant E,de Muizon C,Néraudeau D

更新日期：2009-11-24 00:00:00

abstract：:The P23T mutant of human gammaD-crystallin (HGD) is associated with cataract. We have previously investigated the solution properties of this mutant, as well as those of the closely related P23V and P23S mutants, and shown that although mutations at site 23 of HGD do not produce a significant structural change in the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McManus JJ,Lomakin A,Ogun O,Pande A,Basan M,Pande J,Benedek GB

更新日期：2007-10-23 00:00:00

abstract：:The activity of reconstituted cytochrome-c oxidase (EC 1.9.3.1) from bovine heart is stimulated by intraliposomal ADP but not by NaCl of the same ionic strength. A monoclonal antibody which reacts with subunits VIa-H (heart-type) and VIc, due to the evolutionary relationship between these subunits, also stimulates the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anthony G,Reimann A,Kadenbach B

更新日期：1993-03-01 00:00:00

abstract：:Physical activity increases energy metabolism in exercising muscle. Whether acute exercise elicits metabolic changes in nonexercising muscles remains unclear. We show that one of the few genes that is more highly induced in nonexercising muscle than in exercising human muscle during acute exercise encodes angiopoietin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Catoire M,Alex S,Paraskevopulos N,Mattijssen F,Evers-van Gogh I,Schaart G,Jeppesen J,Kneppers A,Mensink M,Voshol PJ,Olivecrona G,Tan NS,Hesselink MK,Berbée JF,Rensen PC,Kalkhoven E,Schrauwen P,Kersten S

更新日期：2014-03-18 00:00:00

abstract：:Six independent lines of evidence point to the existence of heme-containing compounds and/or hemoglobin breakdown products in extracts of trabecular tissues of the large theropod dinosaur Tyrannosaurus rex. These include signatures from nuclear magnetic resonance and electron spin resonance that indicate the presence ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schweitzer MH,Marshall M,Carron K,Bohle DS,Busse SC,Arnold EV,Barnard D,Horner JR,Starkey JR

更新日期：1997-06-10 00:00:00

abstract：:In the penis, nitric oxide (NO) can be formed by both neuronal NO synthase and endothelial NOS (eNOS). eNOS is activated by viscous drag/shear stress in blood vessels to produce NO continuously, a process mediated by the phosphatidylinositol 3-kinase (PI3kinase)/Akt pathway. Here we show that PI3-kinase/Akt physiologi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hurt KJ,Musicki B,Palese MA,Crone JK,Becker RE,Moriarity JL,Snyder SH,Burnett AL

更新日期：2002-03-19 00:00:00

abstract：:The mode of binding of the competitive inhibitor 2-benzyl-3-formylpropanoic acid to the active site of carboxypeptidase A has been studied by x-ray diffraction methods to a resolution of 1.7 A. The actual species bound to the enzyme was determined to be the gem-diol resulting from covalent hydration at the aldehyde ca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Christianson DW,Lipscomb WN

更新日期：1985-10-01 00:00:00

abstract：:Rat thoracic aortic smooth muscle cells (line A10, ATCC CRL 1476) display a high density of atrial natriuretic factor (ANF) receptors. ANF stimulated the accumulation of cGMP in these cells in a time- and dose-dependent fashion. These cells are known to display a high density of vasopressin receptors of the vascular V...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nambi P,Whitman M,Gessner G,Aiyar N,Crooke ST

更新日期：1986-11-01 00:00:00

abstract：:Lon is an ATPase associated with cellular activities (AAA+) protease that controls cell division in response to stress and also degrades misfolded and damaged proteins. Subunits of Lon are known to assemble into ring-shaped homohexamers that enclose an internal degradation chamber. Here, we demonstrate that hexamers o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vieux EF,Wohlever ML,Chen JZ,Sauer RT,Baker TA

更新日期：2013-05-28 00:00:00

abstract：:This study challenges the paradigm that salt marsh plants prevent lateral wave-induced erosion along wetland edges by binding soil with live roots and clarifies the role of vegetation in protecting the coast. In both laboratory flume studies and controlled field experiments, we show that common salt marsh plants do no...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Feagin RA,Lozada-Bernard SM,Ravens TM,Möller I,Yeager KM,Baird AH

更新日期：2009-06-23 00:00:00

abstract：:Femtosecond and subfemtosecond time scales typically rule electron dynamics at metal surfaces. Recent advance in experimental techniques permits now remarkable precision in the description of these processes. In particular, shorter time scales, smaller system sizes, and spin-dependent effects are current targets of in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Muiño RD,Sánchez-Portal D,Silkin VM,Chulkov EV,Echenique PM

更新日期：2011-01-18 00:00:00

abstract：:Type I Interferons (IFNs) are requisite components in antiviral innate immunity. Classically, a Toll-like receptor-dependent pathway induces type I interferons. However, recent recognition of melanoma differentiation associated gene-5 (MDA-5) and retinoic acid inducible gene-I (RIG-I) as primary sensors of RNA viruses...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sarkar D,Desalle R,Fisher PB

更新日期：2008-11-04 00:00:00

abstract：:It was previously shown that coexpression of the lactose permease of Escherichia coli in two contiguous fragments leads to functional complementation. We demonstrate here that site-directed thiol crosslinking of coexpressed permease fragments can be used to determine helix proximity in situ without the necessity of pu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu J,Kaback HR

更新日期：1996-12-10 00:00:00

abstract：:Nonribosomal peptides and polyketides are a diverse group of natural products with complex chemical structures and enormous pharmaceutical potential. They are synthesized on modular nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS) enzyme complexes by a conserved thiotemplate mechanism. Here, we rep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang H,Fewer DP,Holm L,Rouhiainen L,Sivonen K

更新日期：2014-06-24 00:00:00

abstract：:African trypanosomes are protected by a densely packed surface monolayer of variant surface glycoprotein (VSG). A haptoglobin-hemoglobin receptor (HpHbR) within this VSG coat mediates heme acquisition. HpHbR is also exploited by the human host to mediate endocytosis of trypanolytic factor (TLF)1 from serum, contributi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Higgins MK,Tkachenko O,Brown A,Reed J,Raper J,Carrington M

更新日期：2013-01-29 00:00:00

abstract：:Freshwater planarian flatworms are capable of regenerating complete organisms from tiny fragments of their bodies; the basis for this regenerative prowess is an experimentally accessible stem cell population that is present in the adult planarian. The study of these organisms, classic experimental models for investiga...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Newmark PA,Reddien PW,Cebrià F,Sánchez Alvarado A

更新日期：2003-09-30 00:00:00

abstract：:Immune responses can interfere with the effective use of therapeutic proteins to treat genetic deficiencies and have been challenging to manage. To address this problem, we adapted and studied methods of immune tolerance used in canine organ transplantation research to soluble protein therapeutics. A tolerization regi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kakkis E,Lester T,Yang R,Tanaka C,Anand V,Lemontt J,Peinovich M,Passage M

更新日期：2004-01-20 00:00:00

abstract：:For over 40 y the dominant theory of stomatal behavior has been that plants should open stomates until the carbon gained by an infinitesimal additional opening balances the additional water lost times a water price that is constant at least over short periods. This theory has persisted because of its remarkable succes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wolf A,Anderegg WR,Pacala SW

更新日期：2016-11-15 00:00:00

abstract：:Despite extensive studies, the structural basis for the mechanochemical coupling in the rotary molecular motor F1-ATPase (F1) is still incomplete. We performed single-molecule FRET measurements to monitor conformational changes in the stator ring-α3β3, while simultaneously monitoring rotations of the central shaft-γ. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sugawa M,Okazaki K,Kobayashi M,Matsui T,Hummer G,Masaike T,Nishizaka T

更新日期：2016-05-24 00:00:00

abstract：:SecA, the translocation ATPase in Escherichia coli, undergoes cycles of conformational changes (insertion/deinsertion) in response to ATP and a preprotein. The membrane-embedded portion of protein translocase, SecYEG, has crucial roles in the SecA-driven preprotein translocation reaction. We previously identified a se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matsumoto G,Mori H,Ito K

更新日期：1998-11-10 00:00:00

abstract：:Cotransfection assays were used to show that the members of the GTP-binding protein Gq class of alpha subunits could activate phospholipase C (PLC) beta 2. Similar experiments also demonstrated that G beta 1 gamma 1, G beta 1 gamma 5, and G beta 2 gamma 5 could activate the beta 2 isoform of PLC but not the beta 1 iso...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu D,Katz A,Simon MI

更新日期：1993-06-01 00:00:00

abstract：:Plasma membrane fractions from Xenopus laevis oocytes were incorporated into planar lipid bilayers. We show the existence of numerous Ca2+-activated nonspecific channels that are more permeable to anions. These channels are activated by Ca2+ at micromolar concentration but not by Mg2+, Zn2+, or Mn2+, even at millimola...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Young GP,Young JD,Deshpande AK,Goldstein M,Koide SS,Cohn ZA

更新日期：1984-08-01 00:00:00

abstract：:How much free energy is irreversibly lost during a thermodynamic process? For deterministic protocols, lower bounds on energy dissipation arise from the thermodynamic friction associated with pushing a system out of equilibrium in finite time. Recent work has also bounded the cost of precisely moving a single degree o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bryant SJ,Machta BB

更新日期：2020-02-18 00:00:00

abstract：:Huntington disease stems from a mutation of the protein huntingtin and is characterized by selective loss of discrete neuronal populations in the brain. Despite a massive loss of neurons in the corpus striatum, NO-generating neurons are intact. We recently identified a brain-specific protein that associates with hunti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li XJ,Sharp AH,Li SH,Dawson TM,Snyder SH,Ross CA

更新日期：1996-05-14 00:00:00

abstract：:The development of Drosophila requires the function of the CREB-binding protein, dCBP. In flies, dCBP serves as a coactivator for the transcription factors Cubitus interruptus, Dorsal, and Mad, and as a cosuppressor of Drosophila T cell factor. Current models propose that CBP, through its intrinsic and associated hist...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bantignies F,Goodman RH,Smolik SM

更新日期：2002-03-05 00:00:00

abstract：:AAV is unique among eukaryotic viruses in the ability of its DNA to integrate preferentially into a specific region of the human genome. Understanding AAV integration may aid in developing gene therapy systems with predictable integration sites. Using a gel mobility-shift assay, we have identified a DNA sequence withi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weitzman MD,Kyöstiö SR,Kotin RM,Owens RA

更新日期：1994-06-21 00:00:00